Abstract:
Prostaglandins are present in the epididymal and prostatic portions of the isolated intact and gonadectomized rat vas deferens. The concentration of PGF-like material is higher in the castrated than in the intact male rat in both portions of the vasa deferentia. The higher amount of PGF-like material observed in the castrated rat vas deferens was significantly reduced after testosterone replacement therapy, indicating that androgens could be controlling PGF production. On the other hand, the concentration of PGE-like material was significantly higher than PGF in both portions of the vas deferens and no differences were observed in those values when comparing data from intact, castrated and testosterone-treated rats. PGF-like material is likely to be androgen dependent, whereas PGE-like material is not under that hormonal control. © 1981.
Registro:
Documento: |
Artículo
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Título: | Testosterone regulates prostaglandin production by the rat vas deferens |
Autor: | Borda, E.; Peredo, H.; del C. Agostini, M.; Gimeno, M.F.; Gimeno, A.L. |
Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V.de Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | indometacin; prostaglandin; testosterone; testosterone propionate; animal experiment; castration; endocrine system; male genital system; rat; vas deferens; Animals; Castration; Male; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Testis; Testosterone; Vas Deferens |
Año: | 1981
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Volumen: | 7
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Número: | 3
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Página de inicio: | 245
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Página de fin: | 251
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DOI: |
http://dx.doi.org/10.1016/0161-4630(81)90103-8 |
Título revista: | Prostaglandines and Medicine
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ISSN: | 01614630
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CAS: | indometacin, 53-86-1, 74252-25-8, 7681-54-1; testosterone, 58-22-0; testosterone propionate, 57-85-2; Prostaglandins; Prostaglandins E; Prostaglandins F; Testosterone, 58-22-0
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01614630_v7_n3_p245_Borda |
Referencias:
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- Vane, The use of isolated organs for detection active substances in the circulating blood (1964) Br. J. Phermac. Chemother., 23, p. 360
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- Saksena, Lau, Chang, Effect of intro-scrotal implants of Prostaglandin E2 or F2α on blood steroids in the adult male rats (1978) International J. Andrology, 1, p. 180
- Bartke, Koerner, Androgenic regulation of the concentration of prostaglandin F in the male reproductive system of rats and mice (1974) Endocrinology, 95, p. 1739
- Badr, Effect of sexual maturation and androgens on prostaglandin levels in tissue of the male reproductive system in mice (1976) Endocrinology, 98, p. 1523
- Sutherland, Telli, Singhal, The influence of testosterone on the endogenous levels of prostaglandin F in the accesory reproductive glands of the adult male rat (1974) Can. J. Physiol. Pharm., 52, p. 364
- Gerozissis, Dray, Selective and age-dependent changes of prostaglandin E2 in the epididymis and vas deferens of the rat (1977) J. Reprod. Fert., 50, p. 113
- Skakkebaek, Kelly, Corker, Prostaglandin concentrations in the semen of hypogonadal men during treatment with testosterone (1976) J. Reprod. Fert., 47, p. 119
- Rej, Chatterjee, The possible mode of action of prostaglandins. A study to asses the local effect of prostaglandins E1, E2 or F2α in the regulation of male fertility (1980) Prostaglandins and Medicine, 4, p. 465
- Bartke, Musto, Caldwell, Behrman, Effects of a cholesterol inhibitor and of prostaglandin F2α on testis cholesterol and on plasma testosterone in mice (1973) Prostaglandins, 3, p. 97
- Saksena, Safoury, Bartke, Prostaglandin E2 and F2α decrease plasma testosterone levels in male rats (1973) Prostaglandins, 4, p. 235
- Chantharaksri, Fuchs, PGF2α regulation of LH action on testicular testosterone production (1980) Adv. PGs and Tx. Res., 8, p. 1313
Citas:
---------- APA ----------
Borda, E., Peredo, H., del C. Agostini, M., Gimeno, M.F. & Gimeno, A.L.
(1981)
. Testosterone regulates prostaglandin production by the rat vas deferens. Prostaglandines and Medicine, 7(3), 245-251.
http://dx.doi.org/10.1016/0161-4630(81)90103-8---------- CHICAGO ----------
Borda, E., Peredo, H., del C. Agostini, M., Gimeno, M.F., Gimeno, A.L.
"Testosterone regulates prostaglandin production by the rat vas deferens"
. Prostaglandines and Medicine 7, no. 3
(1981) : 245-251.
http://dx.doi.org/10.1016/0161-4630(81)90103-8---------- MLA ----------
Borda, E., Peredo, H., del C. Agostini, M., Gimeno, M.F., Gimeno, A.L.
"Testosterone regulates prostaglandin production by the rat vas deferens"
. Prostaglandines and Medicine, vol. 7, no. 3, 1981, pp. 245-251.
http://dx.doi.org/10.1016/0161-4630(81)90103-8---------- VANCOUVER ----------
Borda, E., Peredo, H., del C. Agostini, M., Gimeno, M.F., Gimeno, A.L. Testosterone regulates prostaglandin production by the rat vas deferens. 1981;7(3):245-251.
http://dx.doi.org/10.1016/0161-4630(81)90103-8