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Abstract:

The antiandrogens flutamide and casodex have been administered subcutaneously (vehicle, 1, 5, or 10 mg per day) to prepubertal male rats for 10 days. A significant change of epididymal weight has been observed after both treatments, from the lowest dose used. Epididymal dihydrotestosterone concentrations were significantly increased in flutamide- or casodex-treated rats, while epididymal 3α-androstanediol concentrations were affected only after flutamide administration, suggesting a differential effect on androgen metabolism between both antiandrogens. Ornithine decarboxylase (ODC) activity was significantly decreased by flutamide, and to a lesser extent by casodex. Antiandrogen administration resulted in a significant decrease in epididymal content of the polyamines putrescine, spermidine, and spermine. A slight but significant decrease in putrescine and spermidine concentrations, but not in spermine, was observed after flutamide treatment. However, casodex had no effects on polyamines levels. A decrease in putrescine concentration was detected only when ODC activity fell to rather low levels. Interference of the antiandrogens with the biological action of androgens on ODC activity was clearly seen in immature male rats. Therefore, both epididymal growth and differentiation, in correlation to ODC activity, would be severely affected at an early period of sexual development, such as prepuberty.

Registro:

Documento: Artículo
Título:Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration
Autor:Rulli, S.B.; Gonzalez-Calvar, S.I.; Calandra, R.S.
Filiación:Inst. de Biol. y Med. Experimental, Buenos Aires, Argentina
Facultad de Medicina, UBA, Buenos Aires, Argentina
Cátedra de Endocrinologia, Facultad de Ciencias Exactas, UNLP, La Plata, Argentina
Laboratorio de Esteroides, Inst. de Biol. y Med. Experimental, Vuelta de Obligado 2490, (1428), Buenos Aires, Argentina
Palabras clave:casodex; epididymis; flutamide; ornithine decarboxylase; polyamines; androgen; androstanolone; antiandrogen; bicalutamide; flutamide; ornithine decarboxylase; polyamine; putrescine; spermidine; spermine; article; controlled study; development; drug effect; enzyme activity; epididymis; male; nonhuman; polyamine metabolism; prepuberty; priority journal; rat; subcutaneous drug administration
Año:1997
Volumen:38
Número:2
Página de inicio:163
Página de fin:171
DOI: http://dx.doi.org/10.3109/01485019708987894
Título revista:Archives of Andrology
Título revista abreviado:ARCH. ANDROL.
ISSN:01485016
CODEN:ARAND
CAS:androstanolone, 521-18-6; bicalutamide, 90357-06-5; flutamide, 13311-84-7; ornithine decarboxylase, 9024-60-6; putrescine, 110-60-1, 333-93-7; spermidine, 124-20-9, 334-50-9; spermine, 306-67-2, 71-44-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01485016_v38_n2_p163_Rulli

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Citas:

---------- APA ----------
Rulli, S.B., Gonzalez-Calvar, S.I. & Calandra, R.S. (1997) . Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration. Archives of Andrology, 38(2), 163-171.
http://dx.doi.org/10.3109/01485019708987894
---------- CHICAGO ----------
Rulli, S.B., Gonzalez-Calvar, S.I., Calandra, R.S. "Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration" . Archives of Andrology 38, no. 2 (1997) : 163-171.
http://dx.doi.org/10.3109/01485019708987894
---------- MLA ----------
Rulli, S.B., Gonzalez-Calvar, S.I., Calandra, R.S. "Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration" . Archives of Andrology, vol. 38, no. 2, 1997, pp. 163-171.
http://dx.doi.org/10.3109/01485019708987894
---------- VANCOUVER ----------
Rulli, S.B., Gonzalez-Calvar, S.I., Calandra, R.S. Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration. ARCH. ANDROL. 1997;38(2):163-171.
http://dx.doi.org/10.3109/01485019708987894