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Polo, C.F.; Afonso, S.G.; Navone, N.M.; Rossetti, M.V.; Batlle, A.M.D.C. "Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure" (1995) Ecotoxicology and Environmental Safety. 32(3):267-272
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Abstract:

The correlation between blood lead level (BLL), δ-aminolevulinate dehydratase (ALA-D) activity, and other common biochemical parameters used to assess a plumbism diagnosis have been carefully analyzed, with the aim of correctly interpreting the data handled in the laboratory. No correlation was observed between BLL and free erythrocyte porphyrins. In the case of ALA-D or Zn-reactivated ALA-D despite the direct correlation with BLL, the curve follows a potential or a logarithmic line, which is not the best to calculate BLL. The so-called Zn-ALA-D-reactivation index (iZn) has been defined as the ratio between the activity of Zn-reactivated ALA-D and the activity of ALA-D. The plot of BLL against the iZn revealed a very good linear relationship which allows an estimate of BLL with reasonable accuracy within a very wide range. © 1995 by Academic Press, Inc.

Registro:

Documento: Artículo
Título:Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure
Autor:Polo, C.F.; Afonso, S.G.; Navone, N.M.; Rossetti, M.V.; Batlle, A.M.D.C.
Filiación:Centro de Investigaciones sobre Porftrinas y Porfirias (CIPYP) (CONICET—FCEN, UBA), Ciudad Universitaria, Pabellón II, 2do Piso, 1428 Buenos Aires, Argentina
Palabras clave:lead; porphobilinogen synthase; porphyrin; zinc; article; enzyme activity; enzyme assay; erythrocyte; erythropoiesis; heme synthesis; human; human cell; lead blood level; lead poisoning; Adult; Alanine; Binding Sites; Child; Child, Preschool; Erythrocytes; Female; Hemoglobins; Humans; Lead; Lead Poisoning; Male; Porphobilinogen; Porphobilinogen Synthase; Porphyrins; Reference Standards; Reproducibility of Results; Spectrophotometry, Atomic; Zinc
Año:1995
Volumen:32
Número:3
Página de inicio:267
Página de fin:272
DOI: http://dx.doi.org/10.1006/eesa.1995.1113
Título revista:Ecotoxicology and Environmental Safety
Título revista abreviado:Ecotoxicol. Environ. Saf.
ISSN:01476513
CAS:Alanine, 56-41-7; Hemoglobins; Lead, 7439-92-1; Porphobilinogen Synthase, EC 4.2.1.24; Porphobilinogen, 487-90-1; Porphyrins; Zinc, 7440-66-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v32_n3_p267_Polo

Referencias:

  • Batlle, A.N.D., Ferramola, A.M., Grinstein, M., Purification and general properties of delta-aminolevulinic acid dehydratase from cow liver (1967) Biochem. J., 204, pp. 244-249
  • Bonsignore, C., S-Aminolevulininate dehydratase activity of erythrocytes as a diagnostic test in occupational lead poisoning (1966) Med. Lav., 57, pp. 647-650
  • Bonsignore, D., Calissano, C., Cartasegna, C., Sul mecanismo di inhibizione da plomo dell ALA-deidratasi eritrocitaria (1965) Med. Lav., 56, pp. 727-731
  • Borden, E., Cantrell, A., Kilroe-Smith, T., The in vitro effect of zinc on the inhibition of human 8-aminolevulinic acid dehydratase (1976) Br. J. Med., 33, pp. 85-87
  • Bryce-Smith, D., Ward, N.I., Lead and children (1987) Nature, 330, pp. 703-707
  • Bustos, N., Stella, A.M., Wider, E.A., Batlle, A.M.D., Enzyme replacement therapy in porphyrias III: Potential use of erythrocyte ghosts as carriers of 8-aminolevulinate dehydratase (1983) Int. J. Biochem., 15, pp. 447-452
  • Chilsom, J., Thomas, D., Hamill, T., Erythrocyte porphobilinogen synthase activity as an indicator of lead exposure in children (1985) Clin. Chem., 31, pp. 601-605
  • David, O., Grad, G., McGann, B., Koltun, A., Mental retardation and “non-toxic” lead levels (1982) Am. J. Psych., 139, pp. 806-809
  • De Bruin, A., Effect of lead exposure on the level of 5-aminolevulinic dehydratase activity (1968) Med. Lav., 59, pp. 411-418
  • Drasch, G.A., Kretschener, E., Lochner, C., Lead and sudden infant death. Investigations on blood samples of SID babies (1988) Eur. J. Ped., 147, pp. 79-84
  • Granick, J.L., Sassa, S., Granick, S., Studies in lead poisoning. II. Correlation between the ratio of activated to inactivated 8-aminolevulinic acid dehydratase of whole blood and the blood lead level (1973) Biochem. Med., 8, pp. 149-159
  • Hemberg, S., Nikhanen, J., Mellin, G., Lilius, H., 8-Aminolevulinic acid dehydratase as a measure of lead exposure (1970) Arch. Environ. Health, 21, pp. 145-149
  • Kesten, E., Stella, A.M., Wider, E., Batlle, A.M.D., Effect of cadmium on porphyrin biosynthesis, I (1980) Int. J. Biochem., 12, pp. 905-908
  • Lauwerys, R., Buchet, J., Occupational exposure to mercury vapors and biological action (1973) Arch. Environ. Health, 26, pp. 65-68
  • Lauwerys, R., Buchet, J., Roels, H., Comparative study of effect of inorganic lead and cadmium on blood 8-aminolevulinate dehydratase in man (1973) Br. J. Med., 30, pp. 359-365
  • Massaro, E., Massaro, T., Low level lead exposure during neonatal development perturbs cognitive function (1987) J. Am. Col. Toxicol., 6, pp. 441-450
  • Mauzerall, D., Granick, S., The occurrence and determination of 8-aminolevulinic acid and porphobilinogen in urine (1956) J. Biol. Chem., 219, pp. 435-446
  • Mitchell, R., Drake, J., Witthin, L., Rejent, T., Erythrocyte porphobilinogen synthase (8-aminolaevulinate dehydratase) activity: A reliable and quantitative indicator of lead exposure in humans (1977) Clin. Chem., 23, pp. 105-111
  • Moore, M., Beattie, A., Thompson, G., Goldberg, A., Depression of 5-aminolaevulic acid dehydratase activity by ethanol in man and rat (1971) Clin. Sci., 40, pp. 81-88
  • Nakao, K., Wada, O., Yano, Y., 8-Aminolevulinic acid dehydratase activity in erythrocytes for evaluation of lead poisoning (1968) Clin. Chim. Acta, 19, pp. 319-325
  • Nandi, D., Shemin, D., Aminolevulinate dehydratase in Rp sphe-roides. I. Isolation and mechanism (1968) J. Biol. Chem., 243, pp. 1224-1230
  • Piomelli, S., Free erythrocyte porphyrins in the detection of undue absorption of Pb and Fe deficiency (1977) Clin. Chem., 23, pp. 264-269
  • Polo, F., Afonso, S., Batlle, A.M.D., Un método simplificado para la esterificación y la extracción de ésteres metílicos de porfirinas (1988) Acta Bioq. Clin. Latinoamer., 22, pp. 439-441
  • Roels, M., Buchet, J., Lauwerys, R., Sonnet, J., Comparison of in vitro effect of inorganic lead and cadmium on reductase system and 8-ami-nolevulinic acid dehydratase in human erythrocytes (1975) Br. J. Ind. Med., 32, pp. 181-192
  • Sakai, T., Yavaghira, S., Ushio, K., Restoration of lead-inhibited 5-aminolevulinate dehydratase activity in whole blood by heat, zinc ion and (Or) dithiothreitol (1980) Clin. Chem., 26, pp. 625-628
  • Sassa, S., Granick, S., Kappas, A., Effect of lead and genetic factors on heme biosynthesis in the human red cell (1975) Ann. N.Y. Acad. Sci., 244, pp. 140-419
  • Six, M., Goyer, R., Influence of iron deficiency on tissue content and toxicity of ingested lead in the rat (1972) J. Lab. Clin. Med., 79, pp. 128-136
  • Vallee, B., Ulmer, D., Biochemical effects of mercury, cadmium and lead (1972) Annu. Rev. Biochem., 41, pp. 91-128
  • Van Kamoen, E., Zijlstra, W., Standardization of hemoglobinom-etry. II. The hemoglobincyanide method (1961) Clin. Chim. Acta, 6, pp. 538-544
  • Wada, O., Toyokawa, K., Suzuki, T., Response to a low concentration of mercury vapor. Relation to human porphyrin metabolism (1969) Arch. Environ. Health, 19, pp. 48-488
  • With, T., Clinical use of porphyrin ester chromatography in urine and feces (1975) Dan. Med. Bull., 22, pp. 74-80

Citas:

---------- APA ----------
Polo, C.F., Afonso, S.G., Navone, N.M., Rossetti, M.V. & Batlle, A.M.D.C. (1995) . Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure. Ecotoxicology and Environmental Safety, 32(3), 267-272.
http://dx.doi.org/10.1006/eesa.1995.1113
---------- CHICAGO ----------
Polo, C.F., Afonso, S.G., Navone, N.M., Rossetti, M.V., Batlle, A.M.D.C. "Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure" . Ecotoxicology and Environmental Safety 32, no. 3 (1995) : 267-272.
http://dx.doi.org/10.1006/eesa.1995.1113
---------- MLA ----------
Polo, C.F., Afonso, S.G., Navone, N.M., Rossetti, M.V., Batlle, A.M.D.C. "Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure" . Ecotoxicology and Environmental Safety, vol. 32, no. 3, 1995, pp. 267-272.
http://dx.doi.org/10.1006/eesa.1995.1113
---------- VANCOUVER ----------
Polo, C.F., Afonso, S.G., Navone, N.M., Rossetti, M.V., Batlle, A.M.D.C. Zinc aminolevulinic acid dehydratase reactivation index as a tool for diagnosis of lead exposure. Ecotoxicol. Environ. Saf. 1995;32(3):267-272.
http://dx.doi.org/10.1006/eesa.1995.1113