Artículo
Scolaro, L.A.; Mersich, S.E.; Damonte, E.B. "Experimental infection of suckling mice with a host range mutant of junin virus" (1991) Journal of Medical Virology. 34(4):237-240
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Abstract:
Experimental infection of three mouse strains with a non‐pathogenic mutant of Junin virus named C167 was compared with respect to the parental XJC13 strain. After intracerebral (ic) or intraperitoneal inoculation, XJC13 was highly virulent for 2 day‐old C3H/HeJ, OF1, and BALB/cJ mouse strains, whereas its derivative C167 was attenuated. Survival of the C167‐infected mouse was associated with a restricted replication at the site of inoculation which would impair spread of virus. Thus, the reduced virulence of C167 for suckling mice is independent of the mouse strain and the route of viral entry. When C167 was preinoculated ic I0 days before the challenge inoculation with XJC13 by the same route, mice were partially protected from lethal infection. Since neutralizing antibodies were first detected at 30 days post‐infection, an interference mechanism is postulated as a mechanism of protection of the mice. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company
Registro:
| Documento: | Artículo |
| Título: | Experimental infection of suckling mice with a host range mutant of junin virus |
| Autor: | Scolaro, L.A.; Mersich, S.E.; Damonte, E.B. |
| Filiación: | Laboratorio de Virología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina |
| Palabras clave: | attenuated mutant; mouse strain susceptibility; protection; neutralizing antibody; virus vaccine; animal experiment; animal model; antibody detection; article; immune response; immunization; junin virus; mouse; newborn; nonhuman; priority journal; provocation test; virus attenuation; virus infection; virus mutant; Animal; Antibodies, Viral; Arenaviruses, New World; Disease Models, Animal; Hemorrhagic Fever, American; Kinetics; Mice; Mice, Inbred Strains; Mutation; Neutralization Tests; Plaque Assay; Support, Non-U.S. Gov't; Vero Cells; Virulence |
| Año: | 1991 |
| Volumen: | 34 |
| Número: | 4 |
| Página de inicio: | 237 |
| Página de fin: | 240 |
| DOI: | http://dx.doi.org/10.1002/jmv.1890340408 |
| Título revista: | Journal of Medical Virology |
| Título revista abreviado: | J. Med. Virol. |
| ISSN: | 01466615 |
| CAS: | Antibodies, Viral |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01466615_v34_n4_p237_Scolaro |
Referencias:
- Boxaca, MC, Giovanniello, OA, Nota, NR, Nejamkis, MR, de Guerrero, LB, Frigerio, MJ, Estudio de la infección experimental del ratón por virus Junín: Cuadro clínico y susceptibilidad (1973) Revista de la Asociación Argentina de Microbiología, 5, pp. 2-12
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- Scolaro, LA, Mersich, SE, Damonte, EB, Reduced virulence of a Junin virus mutant is associated with restricted multiplication in murine cells (1989) Virus Research, 13, pp. 283-294
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Citas:
---------- APA ----------
Scolaro, L.A., Mersich, S.E. & Damonte, E.B. (1991) . Experimental infection of suckling mice with a host range mutant of junin virus. Journal of Medical Virology, 34(4), 237-240.http://dx.doi.org/10.1002/jmv.1890340408
---------- CHICAGO ----------
Scolaro, L.A., Mersich, S.E., Damonte, E.B. "Experimental infection of suckling mice with a host range mutant of junin virus" . Journal of Medical Virology 34, no. 4 (1991) : 237-240.http://dx.doi.org/10.1002/jmv.1890340408
---------- MLA ----------
Scolaro, L.A., Mersich, S.E., Damonte, E.B. "Experimental infection of suckling mice with a host range mutant of junin virus" . Journal of Medical Virology, vol. 34, no. 4, 1991, pp. 237-240.http://dx.doi.org/10.1002/jmv.1890340408
---------- VANCOUVER ----------
Scolaro, L.A., Mersich, S.E., Damonte, E.B. Experimental infection of suckling mice with a host range mutant of junin virus. J. Med. Virol. 1991;34(4):237-240.http://dx.doi.org/10.1002/jmv.1890340408
