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Abstract:

Antigenic relationships between attenuated and pathogenic strains of Junin virus (JV) were investigated. Five strains of either human or rodent origin were tested by cross‐neutralization assay with hyperimmune antisera, raised in rabbits, against each strain. Polyclonal antisera could be used to distinguish among these JV strains, as the titer values differed significantly with ratios of homologous to heterologous titers, which ranged from 1.3 to 22.3. This demonstrates, independent of their virulence, a heterogeneity among the JV strains tested. The relatedness among JV strains was expressed quantitatively through a dendrogram based on taxonomic distance coefficients. The field strains of JV were grouped into two clusters, according to their geographic origin. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company

Registro:

Documento: Artículo
Título:Antigenic relationships between attenuated and pathogenic strains of junin virus
Autor:Candurra, N.A.; Damonte, E.B.; Coto, C.E.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:antigenic relationships; Argentinian hemorrhagic fever; differentiation of strains; Junin virus; neutralization; serology; virus antigen; classification; hemorrhagic fever; junin virus; nonhuman; priority journal; virus attenuation; virus neutralization; virus strain; virus virulence; Animal; Arenaviridae; Arenaviruses, New World; Epitopes; Guinea Pigs; Immune Sera; Mice; Neutralization Tests; Support, Non-U.S. Gov't; Virulence
Año:1989
Volumen:27
Número:2
Página de inicio:145
Página de fin:150
DOI: http://dx.doi.org/10.1002/jmv.1890270215
Título revista:Journal of Medical Virology
Título revista abreviado:J. Med. Virol.
ISSN:01466615
CAS:Epitopes; Immune Sera
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01466615_v27_n2_p145_Candurra

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Citas:

---------- APA ----------
Candurra, N.A., Damonte, E.B. & Coto, C.E. (1989) . Antigenic relationships between attenuated and pathogenic strains of junin virus. Journal of Medical Virology, 27(2), 145-150.
http://dx.doi.org/10.1002/jmv.1890270215
---------- CHICAGO ----------
Candurra, N.A., Damonte, E.B., Coto, C.E. "Antigenic relationships between attenuated and pathogenic strains of junin virus" . Journal of Medical Virology 27, no. 2 (1989) : 145-150.
http://dx.doi.org/10.1002/jmv.1890270215
---------- MLA ----------
Candurra, N.A., Damonte, E.B., Coto, C.E. "Antigenic relationships between attenuated and pathogenic strains of junin virus" . Journal of Medical Virology, vol. 27, no. 2, 1989, pp. 145-150.
http://dx.doi.org/10.1002/jmv.1890270215
---------- VANCOUVER ----------
Candurra, N.A., Damonte, E.B., Coto, C.E. Antigenic relationships between attenuated and pathogenic strains of junin virus. J. Med. Virol. 1989;27(2):145-150.
http://dx.doi.org/10.1002/jmv.1890270215