Lavandera, J.V.; Fossati, M.; Azcurra, J.; Batlle, A.; Buzaleh, A.M. "Glutamatergic system: Another target for the action of porphyrinogenic agents" (2009) Cellular and Molecular Biology. 55(1):23-28
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The N-methyl-diethyl-aspartate (NMDA) receptor has been reported to play an important role in several acute and chronic neuropathologic syndromes. 5-aminolevulinic acid (ALA) accumulates in acute porphyrias due to a deficiency in the heme biosynthetic pathway. Considering that glutamate uptake inhibition caused by ALA could be one of the reasons conducing to porphyric neuropathy, it was of interest to evaluate the effect of porphyrinogenic agents on NMDA glutamatergic system. To this end receptor levels and apparent affinity (Kd) were analyzed in mice brain cortex and cerebellum. NMDA levels were diminished after chronic Isoflurane anaesthesia in brain cortex. In cerebellum, a diminution was observed after acute Enflurane and Isoflurane and allylisopropylacetamide, while ethanol administration showed a significant increase. ALA administration diminished NMDA levels only in cerebellum. Affinity constant was only reduced in brain cortex after chronic Isoflurane treatment. In conclusion, glutamatergic system appears to be involved in the action of some of the porphyrinogenic drugs studied mainly in cerebellum. Receptors regulation should therefore be considered an important mechanism in the cellular response to specific drugs, with the aim of designing new therapies and elucidating the mechanisms leading to porphyric neuropathy and acute attack triggering. Copyright © 2009 C.M.B. Edition.


Documento: Artículo
Título:Glutamatergic system: Another target for the action of porphyrinogenic agents
Autor:Lavandera, J.V.; Fossati, M.; Azcurra, J.; Batlle, A.; Buzaleh, A.M.
Filiación:Centro de Investigaciones Sobre Porfirinas Y Porfirias (CIPYP), Hospital de Clínicas José de San Martín, University of Buenos Aires, Argentina
Laboratorio de Biología Celular, Department of Biodiversity and Experimental Biology, University of Buenos Aires, Argentina
Department of Biological Chemistry, Facultad de Ciencias Exactas Y Naturales, University of Buenos Aires, Argentina
México 1168 PB 19, C1097AAX - Buenos Aires, Argentina
Palabras clave:Glutamatergic system; N-methyl-diethyl-aspartate; Porphyric neuropathy; Porphyrinogenic agents; allylisopropylacetamide; aminolevulinic acid; glutamic acid; isoflurane; n methyl dextro aspartic acid receptor; animal experiment; animal model; animal tissue; article; binding affinity; brain cortex; cerebellum; controlled study; drug effect; drug mechanism; male; mouse; neuropathy; nonhuman; porphyria; Aminolevulinic Acid; Animals; Barbital; Cerebellum; Cerebral Cortex; Enflurane; Ethanol; Griseofulvin; Isoflurane; Male; Mice; Porphyrinogens; Receptors, N-Methyl-D-Aspartate; Mus
Página de inicio:23
Página de fin:28
Título revista:Cellular and Molecular Biology
Título revista abreviado:Cell. Mol. Biol.
CAS:allylisopropylacetamide, 299-78-5; aminolevulinic acid, 106-60-5; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; isoflurane, 26675-46-7; Aminolevulinic Acid, 106-60-5; Barbital, 57-44-3; Enflurane, 13838-16-9; Ethanol, 64-17-5; Griseofulvin, 126-07-8; Isoflurane, 26675-46-7; Porphyrinogens; Receptors, N-Methyl-D-Aspartate


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---------- APA ----------
Lavandera, J.V., Fossati, M., Azcurra, J., Batlle, A. & Buzaleh, A.M. (2009) . Glutamatergic system: Another target for the action of porphyrinogenic agents. Cellular and Molecular Biology, 55(1), 23-28.
---------- CHICAGO ----------
Lavandera, J.V., Fossati, M., Azcurra, J., Batlle, A., Buzaleh, A.M. "Glutamatergic system: Another target for the action of porphyrinogenic agents" . Cellular and Molecular Biology 55, no. 1 (2009) : 23-28.
---------- MLA ----------
Lavandera, J.V., Fossati, M., Azcurra, J., Batlle, A., Buzaleh, A.M. "Glutamatergic system: Another target for the action of porphyrinogenic agents" . Cellular and Molecular Biology, vol. 55, no. 1, 2009, pp. 23-28.
---------- VANCOUVER ----------
Lavandera, J.V., Fossati, M., Azcurra, J., Batlle, A., Buzaleh, A.M. Glutamatergic system: Another target for the action of porphyrinogenic agents. Cell. Mol. Biol. 2009;55(1):23-28.