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Abstract:

Previously we found that malnutrition during lactation in rats produces an impairment in the immune response to cholera toxin. In this report we found that malnutrition during lactation provokes in 28-day-old rats an increase of Thy1+ cμ+ cells in gut associated lymphoid tissues concomitantly with a decrease of sIgA+ B cells. No differences were found in the percentages of the IgM+B cell populations. Furthermore, no differences were found in the Peyer's patch (PP) and mesenteric lymph node (MLN) T cell subsets in weaning rats when compared to controls. However, after 1 week of refeeding a higher percentage of the Thy1+ cμ- subset together with a lower percentage of CD5+, CD4+, and CD8+ T cells, were found in malnourished rats when compared to controls. The above results may indicate that B-cell maturation is delayed in malnourished rats at two stages of differentiation: (a) in the passage of pre-B cells (Thy1+ cμ+) to immature B cells (sμ+), and (b) in the switch from sμ+ B cells to sα+ B cells. The decrease of CD5+, CD4+, and CD8+T cells together with and increase of the Thy1+ cμ- subset in gutassociated lymphoid tissues (GALT) may indicate that T-cell maturation is also delayed. Results obtained at weaning may be due to an engraftment by maternal milk-derived lymphocytes in the pups. © 1995 Elsevier Science Ltd.

Registro:

Documento: Artículo
Título:Impairment of B and T cell maturation in gut associated lymphoid tissues due to malnutrition during lactation
Autor:Fló, J.; Elías, F.; Massouh, E.; Roux, M.E.
Filiación:Laboratory of Immunochemistry, Department of Biological Chemistry, Faculty of Exact and Natural Sciences, Buenos Aires, 1428, Argentina
Palabras clave:Gut associated lymphoid tissues; Lymphocyte maturation; Malnutrition; cd4 antigen; cd5 antigen; cd8 antigen; immunoglobulin a; immunoglobulin m; thy 1 antigen; animal cell; article; b lymphocyte differentiation; body weight; controlled study; female; immune response; intestine lymphatic tissue; lactation; lymphocyte differentiation; malnutrition; nonhuman; priority journal; protein blood level; rat; t lymphocyte subpopulation; Animal; Animals, Suckling; B-Lymphocytes; Cell Differentiation; Cells, Cultured; Female; Immunophenotyping; Intestinal Mucosa; Lactation; Lymph Nodes; Microscopy, Fluorescence; Nutrition Disorders; Rats; Rats, Wistar; Support, Non-U.S. Gov't; T-Lymphocytes; Animalia
Año:1994
Volumen:18
Número:6
Página de inicio:543
Página de fin:555
DOI: http://dx.doi.org/10.1016/S0145-305X(06)80008-X
Título revista:Developmental and Comparative Immunology
Título revista abreviado:Dev. Comp. Immunol.
ISSN:0145305X
CODEN:DCIMD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0145305X_v18_n6_p543_Flo

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Citas:

---------- APA ----------
Fló, J., Elías, F., Massouh, E. & Roux, M.E. (1994) . Impairment of B and T cell maturation in gut associated lymphoid tissues due to malnutrition during lactation. Developmental and Comparative Immunology, 18(6), 543-555.
http://dx.doi.org/10.1016/S0145-305X(06)80008-X
---------- CHICAGO ----------
Fló, J., Elías, F., Massouh, E., Roux, M.E. "Impairment of B and T cell maturation in gut associated lymphoid tissues due to malnutrition during lactation" . Developmental and Comparative Immunology 18, no. 6 (1994) : 543-555.
http://dx.doi.org/10.1016/S0145-305X(06)80008-X
---------- MLA ----------
Fló, J., Elías, F., Massouh, E., Roux, M.E. "Impairment of B and T cell maturation in gut associated lymphoid tissues due to malnutrition during lactation" . Developmental and Comparative Immunology, vol. 18, no. 6, 1994, pp. 543-555.
http://dx.doi.org/10.1016/S0145-305X(06)80008-X
---------- VANCOUVER ----------
Fló, J., Elías, F., Massouh, E., Roux, M.E. Impairment of B and T cell maturation in gut associated lymphoid tissues due to malnutrition during lactation. Dev. Comp. Immunol. 1994;18(6):543-555.
http://dx.doi.org/10.1016/S0145-305X(06)80008-X