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Abstract:

In a previous paper we reported the occurrence of a high incidence of lymphomas in N-methyl-N-nitrosourea (MNU)-treated mice, in the course of an experiment of combined chemical-hormonal carcinogenesis in mammary gland, in which we used medroxyprogesterone acetate (MPA) and MNU in different treatment protocols. In this report we have analyzed the action of MPA in the leukemogenic effects of MNU, by specifically selecting for the analysis experimental groups in which only few mammary carcinomas had developed. A high incidence of lymphomas (65%, median latency: 176 days) was registered in MNU-treated mice, and the administration of MPA was associated with a significant reduction in the incidence of lymphomas (P<0.001) in all protocols. Copyright © 2001 Elsevier Science Ltd.

Registro:

Documento: Artículo
Título:Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice
Autor:Pazos, P.; Lanari, C.; Molinolo, A.A.
Filiación:Laboratory of Hormonal Carcinogenesis, Instituto De Biología Y Medicina Experimental (IBYME), Consejo Nacional De Investigaciones Científicas Y Técnicas (CONICET), Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Lymphoma; Medroxyprogesterone acetate; Mice; N-methyl-N-nitrosourea; Progestins; medroxyprogesterone acetate; methylnitrosourea; animal experiment; animal model; animal tissue; article; controlled study; drug effect; female; immunocytochemistry; incidence; lymphoma; mouse; nonhuman; priority journal; protection; Animals; Female; Immunohistochemistry; Incidence; Lymphoma; Medroxyprogesterone 17-Acetate; Methylnitrosourea; Mice; Mice, Inbred BALB C
Año:2001
Volumen:25
Número:2
Página de inicio:165
Página de fin:167
DOI: http://dx.doi.org/10.1016/S0145-2126(00)00116-8
Título revista:Leukemia Research
Título revista abreviado:Leuk. Res.
ISSN:01452126
CODEN:LERED
CAS:Medroxyprogesterone 17-Acetate, 71-58-9; Methylnitrosourea, 684-93-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01452126_v25_n2_p165_Pazos

Referencias:

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  • Lelli, G., Angelelli, B., Giambiasi, M.E., Colalongo, F., Camaggi, C.M., Costanti, B., Strocchi, E., Pannuti, F., The anabolic effect of high dose medroxyprogesterone acetate in oncology (1983) Pharmacol. Res. Commun., 15, pp. 561-568
  • Kurebayashi, J., Yamamoto, S., Otsuki, T., Sonoo, H., Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect (1999) Br. J. Cancer, 79, pp. 631-636
  • Amadori, D., Frassineti, G.L., Flamini, E., Falcini, F., Maltoni, M., Nanni, O., Riccobon, A., Piccinini, C., Clinical and laboratory evaluation of the myeloprotective effect of medroxyprogesterone acetate in head and neck cancer (1992) Eur. J. Cancer, 28 A, pp. 1331-1334
  • Molinolo, A.A., Lanari, C., Charreau, E.H., Sanjuan, N., Pasqualini, C.D., Mouse mammary tumors induced by medroxyprogesterone acetate: immunohistochemistry and hormonal receptors (1987) J. Natl. Cancer Inst., 79, pp. 1341-1350
  • Seidel, H.J., Kreja, L., Leukemia induction by methylnitrosourea (MNU) in selected mouse strains. Effects of MNU on hemopoietic stem cells, the immune system and natural killer cells (1984) J. Cancer Res. Clin. Oncol., 108, pp. 214-220
  • Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H., Molinolo, A.A., Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice (1998) Carcinogenesis, 19, pp. 529-531
  • Guzman, R.C., Osborn, R.C., Swanson, S.M., Sakthivel, R., Hwang, S.I., Miyamoto, S., Nandi, S., Incidence of c-Ki-ras activation in N-methyl-N-nitrosourea-induced mammary carcinomas in pituitary-isografted mice (1992) Cancer Res., 52, pp. 5732-5737

Citas:

---------- APA ----------
Pazos, P., Lanari, C. & Molinolo, A.A. (2001) . Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice. Leukemia Research, 25(2), 165-167.
http://dx.doi.org/10.1016/S0145-2126(00)00116-8
---------- CHICAGO ----------
Pazos, P., Lanari, C., Molinolo, A.A. "Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice" . Leukemia Research 25, no. 2 (2001) : 165-167.
http://dx.doi.org/10.1016/S0145-2126(00)00116-8
---------- MLA ----------
Pazos, P., Lanari, C., Molinolo, A.A. "Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice" . Leukemia Research, vol. 25, no. 2, 2001, pp. 165-167.
http://dx.doi.org/10.1016/S0145-2126(00)00116-8
---------- VANCOUVER ----------
Pazos, P., Lanari, C., Molinolo, A.A. Protective role of medroxyprogesterone acetate on N-methyl-N-nitrosourea-induced lymphomas in BALB/c female mice. Leuk. Res. 2001;25(2):165-167.
http://dx.doi.org/10.1016/S0145-2126(00)00116-8