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Abstract:

Several sulfated polysaccharides were desulfated by heating their pyridinium salts dissolved in dimethyl sulfoxide in a microwave oven. The procedure was applied to different products like a λ-carrageenan, a partially cyclized μ/ν-carrageenan, an agar-like product like corallinan, a fucoidan and a chondroitin sulfate. When their pyridinium salts were generated in carefully chosen conditions, the desulfation proceeds smoothly after 1 min of heating, leading to a removal of 60-93% of the original sulfate present. Some depolymerization was found to occur, but its effect is moderate (yields of the recovered products are 64-89%), even for polysaccharides with labile bonds. An in situ methylation procedure was coupled with the microwave-aided desulfation method in order to facilitate the retrieval of structural data. Both spectroscopical and chemical studies showed that the integrity of the polysaccharides was not affected by this procedure (besides the loss of sulfate and the above-mentioned depolymerization). © 2007 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Microwave-assisted desulfation of sulfated polysaccharides
Autor:Navarro, D.A.; Flores, M.L.; Stortz, C.A.
Filiación:Departamento de Química Orgánica-CIHIDECAR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Farmacognosia, Facultad de Ciencias Naturales-CRIDECIT, Universidad Nacional de la Patagonia San Juan Bosco, Km. 4, 9000 Comodoro Rivadavia, Argentina
Palabras clave:Agaran; Carrageenan; Chondroitin; Desulfation; Fucoidan; Microwave irradiation; Depolymerization; Heating; Microwave irradiation; Microwave ovens; Salts; Spectroscopic analysis; Sulfate minerals; Agaran; Carrageenan; Desulfation; Fucoidan; Polysaccharides
Año:2007
Volumen:69
Número:4
Página de inicio:742
Página de fin:747
DOI: http://dx.doi.org/10.1016/j.carbpol.2007.02.009
Título revista:Carbohydrate Polymers
Título revista abreviado:Carbohydr Polym
ISSN:01448617
CODEN:CAPOD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v69_n4_p742_Navarro

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Citas:

---------- APA ----------
Navarro, D.A., Flores, M.L. & Stortz, C.A. (2007) . Microwave-assisted desulfation of sulfated polysaccharides. Carbohydrate Polymers, 69(4), 742-747.
http://dx.doi.org/10.1016/j.carbpol.2007.02.009
---------- CHICAGO ----------
Navarro, D.A., Flores, M.L., Stortz, C.A. "Microwave-assisted desulfation of sulfated polysaccharides" . Carbohydrate Polymers 69, no. 4 (2007) : 742-747.
http://dx.doi.org/10.1016/j.carbpol.2007.02.009
---------- MLA ----------
Navarro, D.A., Flores, M.L., Stortz, C.A. "Microwave-assisted desulfation of sulfated polysaccharides" . Carbohydrate Polymers, vol. 69, no. 4, 2007, pp. 742-747.
http://dx.doi.org/10.1016/j.carbpol.2007.02.009
---------- VANCOUVER ----------
Navarro, D.A., Flores, M.L., Stortz, C.A. Microwave-assisted desulfation of sulfated polysaccharides. Carbohydr Polym. 2007;69(4):742-747.
http://dx.doi.org/10.1016/j.carbpol.2007.02.009