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Abstract:

Alkaline desulphation of heparin has not been so extensively studied as acid hydrolysis or solvolysis. Heparin was treated with 20% triethylamine (TEA) in aqueous solution under two different sets of experimental conditions. After elimination of the base, the products (H-a and H-b) were subjected to gel chromatography, analysed for total and N-sulphate content, and electrophoretic mobility and characterized by 13C-NMR spectroscopy. Selective 2-O-desulphation of L-iduronic acid residues and partial 6-O-desulphation of 2-amino-2-deoxy-D-glucose was observed, while N-sulphoamino groups remained attached. There was also spectroscopic evidence of the formation of 2,3-anhydro-L-iduronic acid moieties. © 1991.

Registro:

Documento: Artículo
Título:Selective O-desulphation of heparin in triethylamine
Autor:Fraidenraich y Waisman, D.; Cirelli, A.F.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Chemical Reactions - Reaction Kinetics; Chromatographic Analysis - Gel Permeation; Natural Polymers - Chemical Reactions; Nuclear Magnetic Resonance; Desulfation; Heparin; Polysaccharides
Año:1992
Volumen:17
Número:2
Página de inicio:111
Página de fin:114
DOI: http://dx.doi.org/10.1016/0144-8617(92)90103-W
Título revista:Carbohydrate Polymers
Título revista abreviado:Carbohydr Polym
ISSN:01448617
CODEN:CAPOD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v17_n2_p111_FraidenraichyWaisman

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Citas:

---------- APA ----------
Fraidenraich y Waisman, D. & Cirelli, A.F. (1992) . Selective O-desulphation of heparin in triethylamine. Carbohydrate Polymers, 17(2), 111-114.
http://dx.doi.org/10.1016/0144-8617(92)90103-W
---------- CHICAGO ----------
Fraidenraich y Waisman, D., Cirelli, A.F. "Selective O-desulphation of heparin in triethylamine" . Carbohydrate Polymers 17, no. 2 (1992) : 111-114.
http://dx.doi.org/10.1016/0144-8617(92)90103-W
---------- MLA ----------
Fraidenraich y Waisman, D., Cirelli, A.F. "Selective O-desulphation of heparin in triethylamine" . Carbohydrate Polymers, vol. 17, no. 2, 1992, pp. 111-114.
http://dx.doi.org/10.1016/0144-8617(92)90103-W
---------- VANCOUVER ----------
Fraidenraich y Waisman, D., Cirelli, A.F. Selective O-desulphation of heparin in triethylamine. Carbohydr Polym. 1992;17(2):111-114.
http://dx.doi.org/10.1016/0144-8617(92)90103-W