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Abstract:

Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO3/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74 kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources. © 2015 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities
Autor:Ray, S.; Pujol, C.A.; Damonte, E.B.; Ray, B.
Filiación:Natural Products Laboratory, Department of Chemistry, University of Burdwan, West Bengal, 713 104, India
Laboratorio de Virología, Departamento de Química Biológica, Ciudad Universitaria, Pabellón 2 Piso 4, Buenos Aires, 1428, Argentina
Palabras clave:Antiviral drug candidate; Cytotoxicity; Polysaccharide engineering; Scinaia hatei; Bioactivity; Cell membranes; Cytotoxicity; Molecular mass; Viruses; Anionic polysaccharides; Anti-viral drugs; Antiviral activities; Cell-surface heparan; Herpes simplex virus; Hydroxyl functionality; Molecular entities; Scinaia hatei; Sulfur compounds; Human herpesvirus 1; Human herpesvirus 2; Scinaia; Simplexvirus; antivirus agent; glycoside; oligosaccharide; sulfate; xylomannan; animal; chemistry; Chlorocebus aethiops; drug effects; Herpes simplex virus 1; infrared spectroscopy; isolation and purification; molecular weight; red alga; Vero cell line; Animals; Antiviral Agents; Cercopithecus aethiops; Glycosides; Herpesvirus 1, Human; Molecular Weight; Oligosaccharides; Rhodophyta; Spectroscopy, Fourier Transform Infrared; Sulfates; Vero Cells
Año:2015
Volumen:131
Página de inicio:315
Página de fin:321
DOI: http://dx.doi.org/10.1016/j.carbpol.2015.06.019
Título revista:Carbohydrate Polymers
Título revista abreviado:Carbohydr Polym
ISSN:01448617
CODEN:CAPOD
CAS:sulfate, 14808-79-8; Antiviral Agents; Glycosides; Oligosaccharides; Sulfates; xylomannan
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v131_n_p315_Ray

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Citas:

---------- APA ----------
Ray, S., Pujol, C.A., Damonte, E.B. & Ray, B. (2015) . Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities. Carbohydrate Polymers, 131, 315-321.
http://dx.doi.org/10.1016/j.carbpol.2015.06.019
---------- CHICAGO ----------
Ray, S., Pujol, C.A., Damonte, E.B., Ray, B. "Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities" . Carbohydrate Polymers 131 (2015) : 315-321.
http://dx.doi.org/10.1016/j.carbpol.2015.06.019
---------- MLA ----------
Ray, S., Pujol, C.A., Damonte, E.B., Ray, B. "Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities" . Carbohydrate Polymers, vol. 131, 2015, pp. 315-321.
http://dx.doi.org/10.1016/j.carbpol.2015.06.019
---------- VANCOUVER ----------
Ray, S., Pujol, C.A., Damonte, E.B., Ray, B. Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities. Carbohydr Polym. 2015;131:315-321.
http://dx.doi.org/10.1016/j.carbpol.2015.06.019