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Abstract:

Six novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. The incorporation efficiency and solubility during a time period were evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators. The photobiological potentials were evaluated on human nasopharynx KB carcinoma cells. None of the formulations studied showed cytotoxic effects in the absence of light, whereas all of them showed good performance after irradiation. The 50% inhibition of cell proliferation (IC 50) was in the range of 0.21-0.47 μM for Pc9-loaded liposome formulations. A lysosomal localization was found for S-PEG as well as for S. © 2012 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)
Autor:López Zeballos, N.C.; Marino, J.; García Vior, M.C.; Chiarante, N.; Roguin, L.P.; Awruch, J.; Dicelio, L.E.
Filiación:INQUIMAE, Departamento de Química Inorgánica, Analítica y Química Física, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Facultad de Farmacia y Bioquímica, Junín 956, 1113 Buenos Aires, Argentina
Departamento de Química Orgánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina
Palabras clave:KB cells; Liposome; Photocytotoxicity; Photodynamic therapy; Phthalocyanine; Singlet oxygen; Carcinoma cells; Cytotoxic effects; Liposomal formulation; Photobiology; Photocytotoxicity; Photophysical; Photophysics; Phthalocyanine; Singlet oxygen; Tetrakis; Time-periods; Cell proliferation; Liposomes; Oxygen; Photodynamic therapy; Quantum yield; Cytotoxicity
Año:2013
Volumen:96
Número:3
Página de inicio:626
Página de fin:635
DOI: http://dx.doi.org/10.1016/j.dyepig.2012.11.005
Título revista:Dyes and Pigments
Título revista abreviado:Dyes Pigm.
ISSN:01437208
CODEN:DYPID
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v96_n3_p626_LopezZeballos

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Citas:

---------- APA ----------
López Zeballos, N.C., Marino, J., García Vior, M.C., Chiarante, N., Roguin, L.P., Awruch, J. & Dicelio, L.E. (2013) . Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II). Dyes and Pigments, 96(3), 626-635.
http://dx.doi.org/10.1016/j.dyepig.2012.11.005
---------- CHICAGO ----------
López Zeballos, N.C., Marino, J., García Vior, M.C., Chiarante, N., Roguin, L.P., Awruch, J., et al. "Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)" . Dyes and Pigments 96, no. 3 (2013) : 626-635.
http://dx.doi.org/10.1016/j.dyepig.2012.11.005
---------- MLA ----------
López Zeballos, N.C., Marino, J., García Vior, M.C., Chiarante, N., Roguin, L.P., Awruch, J., et al. "Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)" . Dyes and Pigments, vol. 96, no. 3, 2013, pp. 626-635.
http://dx.doi.org/10.1016/j.dyepig.2012.11.005
---------- VANCOUVER ----------
López Zeballos, N.C., Marino, J., García Vior, M.C., Chiarante, N., Roguin, L.P., Awruch, J., et al. Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II). Dyes Pigm. 2013;96(3):626-635.
http://dx.doi.org/10.1016/j.dyepig.2012.11.005