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Abstract:

The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions.

Registro:

Documento: Artículo
Título:Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice
Autor:Pazos, P.; Lanari, C.; Elizalde, P.; Montecchia, F.; Charreau, E.H.; Molinolo, A.A.
Filiación:Inst. de Biol. y Med. Experimental, Inst. de Invest. Hematologicas, Academia Nacional de Medicina, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:estrogen receptor; medroxyprogesterone acetate; methylnitrosourea; progesterone receptor; animal experiment; animal model; animal tissue; article; breast adenocarcinoma; breast carcinogenesis; breast tumor; cell differentiation; controlled study; female; mouse; nonhuman; priority journal; promoter region; Adenocarcinoma; Animals; Carcinogens; Cocarcinogenesis; Female; Mammary Neoplasms, Experimental; Medroxyprogesterone 17-Acetate; Methylnitrosourea; Mice; Mice, Inbred BALB C
Año:1998
Volumen:19
Número:3
Página de inicio:529
Página de fin:531
DOI: http://dx.doi.org/10.1093/carcin/19.3.529
Título revista:Carcinogenesis
Título revista abreviado:Carcinogenesis
ISSN:01433334
CODEN:CRNGD
CAS:Carcinogens; Medroxyprogesterone 17-Acetate, 71-58-9; Methylnitrosourea, 684-93-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01433334_v19_n3_p529_Pazos

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Citas:

---------- APA ----------
Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H. & Molinolo, A.A. (1998) . Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice. Carcinogenesis, 19(3), 529-531.
http://dx.doi.org/10.1093/carcin/19.3.529
---------- CHICAGO ----------
Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H., Molinolo, A.A. "Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice" . Carcinogenesis 19, no. 3 (1998) : 529-531.
http://dx.doi.org/10.1093/carcin/19.3.529
---------- MLA ----------
Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H., Molinolo, A.A. "Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice" . Carcinogenesis, vol. 19, no. 3, 1998, pp. 529-531.
http://dx.doi.org/10.1093/carcin/19.3.529
---------- VANCOUVER ----------
Pazos, P., Lanari, C., Elizalde, P., Montecchia, F., Charreau, E.H., Molinolo, A.A. Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice. Carcinogenesis. 1998;19(3):529-531.
http://dx.doi.org/10.1093/carcin/19.3.529