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Pujol, C.A.; Damonte, E.B.; Turjan, J.; Yanbo, K.Z.; Capek, P. "The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates" (2016) International Journal of Biological Macromolecules. 87:195-200
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Abstract:

Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors. © 2016 Elsevier B.V.

Registro:

Documento: Artículo
Título:The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
Autor:Pujol, C.A.; Damonte, E.B.; Turjan, J.; Yanbo, K.Z.; Capek, P.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso 4, Buenos Aires, 1428, Argentina
Department of Glycomaterials, Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 842 38, Slovakia
School of Chinese Medicine, LKS Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong
Palabras clave:4OMe-glucuronoxylan sulfates; Antiviral activity; Herpes simplex virus; 4 o methylglucuronoxylan sulfate; antivirus agent; arabinose; dextran sulfate; galactose; glucose; glucuronic acid; heparin; unclassified drug; antivirus agent; glucuronoxylan; sulfate; xylan; animal cell; antiviral activity; Article; cytotoxic concentration; Dengue virus 2; drug effect; drug potency; drug sulfation; enzymatic degradation; Fagus sylvatica; Herpes simplex virus 1; Herpes simplex virus 2; Human poliovirus 1; inhibitory concentration; molecular weight; nonhuman; selectivity index; virus inhibition; animal; beech; chemistry; Chlorocebus aethiops; drug effects; Vero cell line; virus; Animals; Antiviral Agents; Cercopithecus aethiops; Fagus; Sulfates; Vero Cells; Viruses; Xylans
Año:2016
Volumen:87
Página de inicio:195
Página de fin:200
DOI: http://dx.doi.org/10.1016/j.ijbiomac.2016.02.048
Título revista:International Journal of Biological Macromolecules
Título revista abreviado:Int. J. Biol. Macromol.
ISSN:01418130
CODEN:IJBMD
CAS:arabinose, 147-81-9; dextran sulfate, 9011-18-1, 9042-14-2; galactose, 26566-61-0, 50855-33-9, 59-23-4; glucose, 50-99-7, 84778-64-3; glucuronic acid, 36116-79-7, 576-37-4, 6556-12-3; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5; sulfate, 14808-79-8; xylan, 9014-63-5; Antiviral Agents; glucuronoxylan; Sulfates; Xylans
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v87_n_p195_Pujol

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Citas:

---------- APA ----------
Pujol, C.A., Damonte, E.B., Turjan, J., Yanbo, K.Z. & Capek, P. (2016) . The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates. International Journal of Biological Macromolecules, 87, 195-200.
http://dx.doi.org/10.1016/j.ijbiomac.2016.02.048
---------- CHICAGO ----------
Pujol, C.A., Damonte, E.B., Turjan, J., Yanbo, K.Z., Capek, P. "The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates" . International Journal of Biological Macromolecules 87 (2016) : 195-200.
http://dx.doi.org/10.1016/j.ijbiomac.2016.02.048
---------- MLA ----------
Pujol, C.A., Damonte, E.B., Turjan, J., Yanbo, K.Z., Capek, P. "The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates" . International Journal of Biological Macromolecules, vol. 87, 2016, pp. 195-200.
http://dx.doi.org/10.1016/j.ijbiomac.2016.02.048
---------- VANCOUVER ----------
Pujol, C.A., Damonte, E.B., Turjan, J., Yanbo, K.Z., Capek, P. The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates. Int. J. Biol. Macromol. 2016;87:195-200.
http://dx.doi.org/10.1016/j.ijbiomac.2016.02.048