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Chattopadhyay, K.; Ghosh, T.; Pujol, C.A.; Carlucci, M.J.; Damonte, E.B.; Ray, B. "Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities" (2008) International Journal of Biological Macromolecules. 43(4):346-351
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Abstract:

In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity. © 2008 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
Autor:Chattopadhyay, K.; Ghosh, T.; Pujol, C.A.; Carlucci, M.J.; Damonte, E.B.; Ray, B.
Filiación:Natural Products Laboratory, Department of Chemistry, The University of Burdwan, WB 713 104, India
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales UBA, Ciudad Universitaria-Pabellon 2 Piso 4, 1428 Buenos Aires, Argentina
Palabras clave:Anti-HSV activity; Galactan sulfate; Gracilaria corticata; antivirus agent; galactan; Gracilaria corticata extract; periodate; polysaccharide; unclassified drug; animal cell; anion exchange chromatography; anticoagulation; antiviral activity; article; controlled study; drug structure; drug sulfation; gel permeation chromatography; Gracilaria; Gracilaria corticata; Herpes simplex virus 1; Herpes simplex virus 2; IC 50; matrix assisted laser desorption ionization time of flight mass spectrometry; molecular weight; nonhuman; nuclear magnetic resonance spectroscopy; Vero cell; Animals; Anticoagulants; Antiviral Agents; Cercopithecus aethiops; Chromatography, Gel; Complex Mixtures; Galactans; Gracilaria; Herpesvirus 1, Human; Herpesvirus 2, Human; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Weight; Oxidation-Reduction; Periodic Acid; Polysaccharides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfates; Vero Cells; Gracilaria corticata; Simplexvirus
Año:2008
Volumen:43
Número:4
Página de inicio:346
Página de fin:351
DOI: http://dx.doi.org/10.1016/j.ijbiomac.2008.07.009
Título revista:International Journal of Biological Macromolecules
Título revista abreviado:Int. J. Biol. Macromol.
ISSN:01418130
CODEN:IJBMD
CAS:galactan, 39300-87-3, 9037-55-2; periodate, 15056-35-6; Anticoagulants; Antiviral Agents; Complex Mixtures; Galactans; metaperiodate, 7790-28-5; Periodic Acid, 10450-60-9; Polysaccharides; Sulfates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v43_n4_p346_Chattopadhyay

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Citas:

---------- APA ----------
Chattopadhyay, K., Ghosh, T., Pujol, C.A., Carlucci, M.J., Damonte, E.B. & Ray, B. (2008) . Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities. International Journal of Biological Macromolecules, 43(4), 346-351.
http://dx.doi.org/10.1016/j.ijbiomac.2008.07.009
---------- CHICAGO ----------
Chattopadhyay, K., Ghosh, T., Pujol, C.A., Carlucci, M.J., Damonte, E.B., Ray, B. "Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities" . International Journal of Biological Macromolecules 43, no. 4 (2008) : 346-351.
http://dx.doi.org/10.1016/j.ijbiomac.2008.07.009
---------- MLA ----------
Chattopadhyay, K., Ghosh, T., Pujol, C.A., Carlucci, M.J., Damonte, E.B., Ray, B. "Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities" . International Journal of Biological Macromolecules, vol. 43, no. 4, 2008, pp. 346-351.
http://dx.doi.org/10.1016/j.ijbiomac.2008.07.009
---------- VANCOUVER ----------
Chattopadhyay, K., Ghosh, T., Pujol, C.A., Carlucci, M.J., Damonte, E.B., Ray, B. Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities. Int. J. Biol. Macromol. 2008;43(4):346-351.
http://dx.doi.org/10.1016/j.ijbiomac.2008.07.009