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Abstract:

Polysaccharides were sequentially extracted from the agarophyte Gracilaria corticata. Chemical analysis combined with infrared spectroscopy showed that the cold water extracted material consists mainly of a high molecular weight sulfated galactan. Most of the sulfate groups are alkali labile and are located at C-4 of the 1,3-linked D-galactose units and C-6 of the 1,4-linked L-galactose residues. The autoclaved extracts contain agar type polysaccharide having a high pyruvate content and a variable degree of methylation, but were contaminated with floridean starch. 1H-NMR studies indicate that methoxyl groups, when present, occur at C-6 of the 1,3-linked D-galactose units and C-2 of the 1,4-linked L-galactose residues of agar polymer. Bioassays showed that a high molecular weight galactan sulfate, exhibited selective antiviral activity against herpes simplex virus types 1 and 2, likely due to an inhibition of the initial virus attachment to the host cell. © 2002 Elsevier Science B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta)
Autor:Mazumder, S.; Ghosal, P.K.; Pujol, C.A.; Carlucci, M.J.; Damonte, E.B.; Ray, B.
Filiación:Department of Chemistry, University of Burdwan, Burdwan 713 104, WB, India
Laboratorio de Virología, Depto. de Quím. Biologica, Facultad de Cie. Exact. y Nat. UBA, Ciudad Universitaria-Pabellon 2, 1428 Buenos Aires, Argentina
UMR CNRS 6037, SCUEOR, Rouen University, 76821 Mont Saint Aignan, France
Palabras clave:Agar; Anti-herpes simplex virus activity; Anticoagulant activity; Galactan sulfate; Gracilaria corticata; Starch; agar; antivirus agent; galactan sulfate; galactose; polysaccharide; pyruvic acid; starch; unclassified drug; alkalinity; animal cell; antiviral activity; article; autoclave; bioassay; carbohydrate analysis; controlled study; drug isolation; gracilaria corticata; Herpes simplex virus 1; Herpes simplex virus 2; infrared spectroscopy; methylation; molecular weight; nonhuman; proton nuclear magnetic resonance; red alga; virus adsorption; virus cell interaction; Agar; Animals; Anticoagulants; Antiviral Agents; Biological Assay; Cercopithecus aethiops; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Galactans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mass Spectrometry; Polysaccharides; Simplexvirus; Spectrophotometry, Infrared; Starch; Sulfates; Vero Cells; Gracilaria; Gracilaria corticata; Gracilariaceae; Rhodophyta; Simplexvirus
Año:2002
Volumen:31
Número:1-3
Página de inicio:87
Página de fin:95
DOI: http://dx.doi.org/10.1016/S0141-8130(02)00070-3
Título revista:International Journal of Biological Macromolecules
Título revista abreviado:Int. J. Biol. Macromol.
ISSN:01418130
CODEN:IJBMD
CAS:agar, 9002-18-0; galactose, 26566-61-0, 50855-33-9, 59-23-4; pyruvic acid, 127-17-3, 19071-34-2, 57-60-3; starch, 9005-25-8, 9005-84-9; Agar, 9002-18-0; Anticoagulants; Antiviral Agents; Galactans; Polysaccharides; Starch, 9005-25-8; Sulfates
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v31_n1-3_p87_Mazumder

Referencias:

  • Franz, G., Pauper, D., Alban, S., (2000) Bioactive carbohydrate polymers, p. 47. , Kluwer Academic Publishers
  • Avramoglou, L.D., Jozefonvicz, J., (1999) J. Biomed. Mater. Res., 48 (4), p. 578
  • Vlietinck, A.J., Bruyne, D.T., Apers, S., Pieters, L.A., (1998) Planta. Med., 64, p. 97
  • Kornprobst, J.M., Sallenave, C., Barnathan, G., (1998) Comp. BioChem. Physio., 119 B, p. 1
  • Cáceres, P.J., Carlucci, M.J., Damonte, E.B., Matsuhiro, B., Zúñiga, E.A., (2000) Phytochemistry, 53, p. 81
  • Feldman, S.C., Reynaldi, S., Stortz, C.A., Cerezo, A.S., Damonte, E.B., (1999) Phytomed, 6, p. 335
  • Lee, J.B., Hayashi, T., Hayashi, K., Sankawa, U., Maeda, M., Nemoto, T., (1998) J. Nat. Prods., 61, p. 1101
  • Carlucci, M.J., Ciancia, M., Matulewicz, M.C., Cerezo, A.S., Damonte, E.B., (1999) Antiviral. Res., 43, p. 93
  • Lee, J.B., Hayashi, K., Hayashi, T., Sankawa, U., Maeda, M., (1999) Planta. Med., 65, p. 439
  • Berge, J.P., Bourgougnon, N., Alban, S., Pojer, F., Billaudel, S., Chermann, J.C., (1999) Planta. Med., 65, p. 604
  • Hoshino, T., Hayashi, T., Hayashi, K., Hamada, J., Lee, J.B., Sankawa, U., (1998) Biol. Pharm. Bull., 21 (7), p. 730
  • Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E., (1996) Chemotherapy, 42, p. 57
  • Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B., (1996) Phytother. Res., 10, p. 410
  • Ivanova, V., Rouseva, R., Kolarova, M., Serkejieva, J., Rachev, R., Manolova, N., (1994) Preparative Biochem., 24, p. 83
  • Bourgougnon, N., Lahaye, M., Chermann, J.C., Kornprobst, J.M., (1993) Bioorganic Med. Chem. Lett., 3, p. 1141
  • Lahaye, M., Rochas, C., Yaphe, W., (1986) Can. J. Bot., 64, p. 579
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., (1951) J. Biol. Chem., 193, p. 265
  • Mazumder, S., Ray, B., Ghosal, P.K., (2001) Asian J. Chem., 13 (4), p. 1389
  • Craigie, J.S., Wen, Z.C., Van der Meer, J.P., (1984) Bot. Mar., 27, p. 55
  • Tabatabai, M.A., (1974) Sulphur Inst. J., 10, p. 11
  • Dubios, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A., Smith, F., (1956) Anal. Chem., 28, p. 350
  • Ahmed, A., Labavitch, J.M., (1977) J. Food. Biochem., 361, p. 1
  • Yaphe, W., Arsenault, G.P., (1965) Anal. Biochem., 13, p. 143
  • Blakeney, A.B., Harris, P., Henry, R.J., Bruce, A.B., (1983) Carbohydr. Res., 113, p. 291
  • Mondal, S.K., Ray, B., Ghosal, P.K., Teleman, A., Vuorinen, T., (2001) Int. J. Biol. Macromol., 29, p. 169
  • Carpita, N.C., Shea, E.M., (1988) Analysis of carbohydrates by GC and MS, p. 157. , C.J. Bermann, & G.D. McGinis. Boca Raton, FL: CRC Press
  • Jansson, P.E., Kenne, L., Liedgren, H., Lindberg, B., Lonngren, J., (1976) A practical guide to the methylation analysis of carbohydrates Chemical communications, 8. , Sweden: University of Stockholm
  • Ray, B., Lahaye, M., (1995) Carbohydr. Res., 274, p. 313
  • Mondal, S.K., Ray, B., Ghosal, P.K., Thakur, S., (2001) Asian J. Chem., 13, p. 182
  • Rochas, C., Lahaye, M., (1989) Carbohydr. Polym., 10, p. 289
  • Knutsen, S.H., Grasdalen, M., (1987) Bot. Mar., 30, p. 497
  • Welti, D., (1977) J. Chem. Res., p. 3566. , Miniprint
  • Lahaye, M., Revol, J.F., Rochas, C., McLachlan, J., Yaphe, W., (1988) Bot. Mar., 31, p. 491
  • Izumi, K., (1973) Biochim. Biophys. Acta, 320, p. 311
  • Painter, T.J., (1983) The polysaccharides, 2, p. 195. , Aspinall G.O. Academic Press Inc
  • Lloyd, A.G., Dogson, K.S., Price, R.G., Rose, F.A., (1961) Biochim. Biophys. Acta, 46, p. 108
  • Rochas, C., Lahaye, M., Yaphe, W., (1986) Bot. Mar., 29, p. 335
  • Stancioff, D.J., Stanley, N.F., (1969) Proc. Int. Seaweed. Symp., 6, p. 595
  • Stanly, N.F., US Patent 1963: 3,094,517; Araki, C., (1966) Proc. Int. Seaweed. Symp., 5, p. 3
  • Murano, E., Toffanin, R., Zanetti, F., Knutsen, S.H., Focher, B., Rizzo, R., (1993) J. Appl. Phycol., 5, p. 417
  • Murano, E., Toffanin, R., Knutsen, S.H., Paoletti, S., Rizzo, R., (1992) Carbohydr. Polym., 18, p. 171
  • Gorin, P.A.J., Mazurek, M., Duarte, H.S., Iacomini, M., Duarte, J.H., (1982) Carbohydr. Res., 100, p. 1
  • Garegg, P.J., Jansson, P.E., Lindberg, B., Lindh, F., Lonngren, J., (1980) Carbohydr. Res., 78, p. 127
  • Lahaye, M., Rochas, C., Yaphe, W., (1985) Carbohydr. Res., 143, p. 240
  • Vignon, M.R., Morgan, E., Rochas, C., (1994) Bot. Mar., 37, p. 325
  • Dais, P., Perlin, A.S., (1982) Carbohydr. Res., 100, p. 103
  • Kolender, A.A., Matulewicz, M.C., Cerezo, A.S., (1995) Carbohydr. Res., 273, p. 179
  • Duarte, M.E.R., Noseda, D.G., Noseda, M.D., Tulio, S., Pujol, C.A., Damonte, E.B., (2001) Phytomedicine, 8, p. 53
  • Witvrouw, M., Este, J.A., Mateu, M.Q., Reymen, D., Andrei, G., Snoeck, R., (1994) Antiviral. Chem. Chemother., 5, p. 297

Citas:

---------- APA ----------
Mazumder, S., Ghosal, P.K., Pujol, C.A., Carlucci, M.J., Damonte, E.B. & Ray, B. (2002) . Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta). International Journal of Biological Macromolecules, 31(1-3), 87-95.
http://dx.doi.org/10.1016/S0141-8130(02)00070-3
---------- CHICAGO ----------
Mazumder, S., Ghosal, P.K., Pujol, C.A., Carlucci, M.J., Damonte, E.B., Ray, B. "Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta)" . International Journal of Biological Macromolecules 31, no. 1-3 (2002) : 87-95.
http://dx.doi.org/10.1016/S0141-8130(02)00070-3
---------- MLA ----------
Mazumder, S., Ghosal, P.K., Pujol, C.A., Carlucci, M.J., Damonte, E.B., Ray, B. "Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta)" . International Journal of Biological Macromolecules, vol. 31, no. 1-3, 2002, pp. 87-95.
http://dx.doi.org/10.1016/S0141-8130(02)00070-3
---------- VANCOUVER ----------
Mazumder, S., Ghosal, P.K., Pujol, C.A., Carlucci, M.J., Damonte, E.B., Ray, B. Isolation, chemical investigation and antiviral activity of polysaccharides from Gracilaria corticata (Gracilariaceae, Rhodophyta). Int. J. Biol. Macromol. 2002;31(1-3):87-95.
http://dx.doi.org/10.1016/S0141-8130(02)00070-3