Artículo
Médici, R.; Garaycoechea, J.I.; Dettorre, L.A.; Iribarren, A.M.; Lewkowicz, E.S. "Biocatalysed halogenation of nucleobase analogues" (2011) Biotechnology Letters. 33(10):1999-2003
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Abstract:
The synthesis of halogenated nucleosides and nucleobases is of interest due to their chemical and pharmacological applications. Herein, the enzymatic halogenation of nucleobases and analogues catalysed by microorganisms and by chloroperoxidase from Caldariomyces fumago has been studied. This latter enzyme catalysed the chlorination and bromination of indoline and uracil. Pseudomonas, Citrobacter, Aeromonas, Streptomyces, Xanthomonas, and Bacillus genera catalysed the chlorination and/or bromination of indole and indoline. Different products were obtained depending on the substrate, the biocatalyst and the halide used. In particular, 85% conversion from indole to 5-bromoindole was achieved using Streptomyces cetonii. © 2011 Springer Science+Business Media B.V.
Registro:
| Documento: | Artículo |
| Título: | Biocatalysed halogenation of nucleobase analogues |
| Autor: | Médici, R.; Garaycoechea, J.I.; Dettorre, L.A.; Iribarren, A.M.; Lewkowicz, E.S. |
| Filiación: | Biotransformation Laboratory, Universidad Nacional de Quilmes, R. S. Peña 352 Bernal, 1876 Buenos Aires, Argentina INGEBI, CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | Enzymatic halogenation; Haloperoxidases; Nucleobases; Whole cell biocatalysts; 5-Bromoindole; Aeromonas; Caldariomyces; Chloroperoxidase; Enzymatic halogenation; Haloperoxidases; Nucleobases; Whole cell biocatalysts; Xanthomonas; Bacteriology; Biocatalysts; Catalysis; Chlorination; Enzymes; Bacteria; chloride peroxidase; chlorodimedone; cyclohexanone derivative; drug derivative; halogenated hydrocarbon; indole derivative; indoline; uracil; article; Ascomycetes; bacterium; biocatalysis; enzymology; halogenation; metabolism; Ascomycota; Bacteria; Biocatalysis; Chloride Peroxidase; Cyclohexanones; Halogenation; Hydrocarbons, Halogenated; Indoles; Uracil; Aeromonas; Citrobacter; Leptoxyphium fumago; Pseudomonas; Streptomyces; Xanthomonas |
| Año: | 2011 |
| Volumen: | 33 |
| Número: | 10 |
| Página de inicio: | 1999 |
| Página de fin: | 2003 |
| DOI: | http://dx.doi.org/10.1007/s10529-011-0655-z |
| Título revista: | Biotechnology Letters |
| Título revista abreviado: | Biotechnol. Lett. |
| ISSN: | 01415492 |
| CODEN: | BILED |
| CAS: | chloride peroxidase, 9055-20-3; indoline, 496-15-1; uracil, 66-22-8; Chloride Peroxidase, 1.11.1.10; Cyclohexanones; Hydrocarbons, Halogenated; Indoles; Uracil, 66-22-8; chlorodimedone, 7298-89-7; indoline, 496-15-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v33_n10_p1999_Medici |
Referencias:
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Citas:
---------- APA ----------
Médici, R., Garaycoechea, J.I., Dettorre, L.A., Iribarren, A.M. & Lewkowicz, E.S. (2011) . Biocatalysed halogenation of nucleobase analogues. Biotechnology Letters, 33(10), 1999-2003.http://dx.doi.org/10.1007/s10529-011-0655-z
---------- CHICAGO ----------
Médici, R., Garaycoechea, J.I., Dettorre, L.A., Iribarren, A.M., Lewkowicz, E.S. "Biocatalysed halogenation of nucleobase analogues" . Biotechnology Letters 33, no. 10 (2011) : 1999-2003.http://dx.doi.org/10.1007/s10529-011-0655-z
---------- MLA ----------
Médici, R., Garaycoechea, J.I., Dettorre, L.A., Iribarren, A.M., Lewkowicz, E.S. "Biocatalysed halogenation of nucleobase analogues" . Biotechnology Letters, vol. 33, no. 10, 2011, pp. 1999-2003.http://dx.doi.org/10.1007/s10529-011-0655-z
---------- VANCOUVER ----------
Médici, R., Garaycoechea, J.I., Dettorre, L.A., Iribarren, A.M., Lewkowicz, E.S. Biocatalysed halogenation of nucleobase analogues. Biotechnol. Lett. 2011;33(10):1999-2003.http://dx.doi.org/10.1007/s10529-011-0655-z
