Artículo
Trelles, J.A.; Valino, A.L.; Runza, V.; Lewkowicz, E.S.; Iribarren, A.M. "Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides" (2005) Biotechnology Letters. 27(11):759-763
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
Modified nucleosides can be prepared by microbial transglycosylation from cheaper nucleoside precursors using free or immobilised whole cells. An efficient screening method to find transglycosylation activity in microorganisms was developed for the synthesis of 6-modified purine nucleosides, such as 6-chloro-, 6-methoxy-, 6-iodo- and 6-mercaptopurine ribonucleoside. Out of 100 microorganisms screened, Bacillus stearothermophilus ATCC 12980 was the best for this purpose. © Springer 2005.
Registro:
| Documento: | Artículo |
| Título: | Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides |
| Autor: | Trelles, J.A.; Valino, A.L.; Runza, V.; Lewkowicz, E.S.; Iribarren, A.M. |
| Filiación: | Universidad Nacional de Quilmes, R.S. Peña 180, (1876), Bernal, Buenos Aires, Argentina INGEBI, CONICET, Vuelta de Obligado 2490, (1428), Buenos Aires, Argentina |
| Palabras clave: | Bacillus stearothermophilus; Microbial transglycosylation; Nucleoside phosphorylases; Nucleosides; Screening; Biosynthesis; Catalysis; Cells; Enzymes; Screening; Bacillus stearothermophiles; Microbial transglycosylation; Nucleoside phosphorylases; Nucleosides; Microorganisms; nucleoside; purine nucleoside; purine nucleoside phosphorylase; article; bacterium; biosynthesis; catalysis; economics; enzymology; Geobacillus stearothermophilus; glycosylation; isolation and purification; metabolism; methodology; microbiology; Bacillus stearothermophilus; Bacteria; Catalysis; Glycosylation; Industrial Microbiology; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Geobacillus stearothermophilus |
| Año: | 2005 |
| Volumen: | 27 |
| Número: | 11 |
| Página de inicio: | 759 |
| Página de fin: | 763 |
| DOI: | http://dx.doi.org/10.1007/s10529-005-5628-7 |
| Título revista: | Biotechnology Letters |
| Título revista abreviado: | Biotechnol. Lett. |
| ISSN: | 01415492 |
| CODEN: | BILED |
| CAS: | purine nucleoside phosphorylase, 9030-21-1, 9075-52-9; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase, EC 2.4.2.1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v27_n11_p759_Trelles |
Referencias:
- Bradshaw, D.M., Arceci, R.J., Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance (1998) J.Clin. Oncol., 16, pp. 3674-3690
- Bzowska, A., Kulikowska, E., Shugar, D., Purine nucleoside phosphorylases: Properties, functions, and clinical aspects (2000) Pharmacol. Ther., 88, pp. 349-425
- Ciuffreda, P., Loseto, A., Santaniello, E., Deamination of 5′-substituted-2′,3′-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5.4.4) and complementary enzymatic biotransformation catalyzed by adenylate deaminase (AMPDA, EC 3.5.4.6): A viable route for the preparation of 5′-substituted inosine derivatives (2002) Tetrahedron, 58, pp. 5767-5771
- Hanrahan, J., Hutchinson, D., The enzymatic synthesis of antiviral agents (1992) J. Biotechnol., 23, pp. 193-210
- Müller, M., Hutchinson, L., Guenngerigh, F., Addiction of deoxyribose to guanine and modified DNA bases by Lactobacillus helveticus trans-N-deoxyribosylase (1996) Chem. Res. Toxicol., 9, pp. 1140-1144
- Nair, V., Richrdson, S.G., Utility of purinyl radicals in the synthesis of base-modified nucleosides and alkylpurines: 6-amino group replacement by H, Cl, Br and I (1980) J. Org. Chem., 45, pp. 3969-3974
- Ogawa, J., Shimizu, S., Microbial enzymes: New industrial application from traditional screening methods (1999) Trends Biotechnol., 17, pp. 13-20
- Prasad, A.K., Trikha, S., Parmar, V.S., Nucleoside synthesis mediated by glycosyl transferring enzymes (1999) Bioorg. Chem., 27, pp. 135-154
- Pugmire, M.J., Ealick, S.E., Structural analyses reveal two distinct families of nucleoside phosphorylases (2002) Biochem. J., 361, pp. 1-25
- Rogert, M.C., Trelles, J.A., Porro, S., Lewkowicz, E.S., Iribarren, A.M., Microbial synthesis of antiviral nucleosides using E. coli BL 21 as biocatalyst (2002) Biocatal. Biotransform., 20, pp. 347-351
Citas:
---------- APA ----------
Trelles, J.A., Valino, A.L., Runza, V., Lewkowicz, E.S. & Iribarren, A.M. (2005) . Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides. Biotechnology Letters, 27(11), 759-763.http://dx.doi.org/10.1007/s10529-005-5628-7
---------- CHICAGO ----------
Trelles, J.A., Valino, A.L., Runza, V., Lewkowicz, E.S., Iribarren, A.M. "Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides" . Biotechnology Letters 27, no. 11 (2005) : 759-763.http://dx.doi.org/10.1007/s10529-005-5628-7
---------- MLA ----------
Trelles, J.A., Valino, A.L., Runza, V., Lewkowicz, E.S., Iribarren, A.M. "Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides" . Biotechnology Letters, vol. 27, no. 11, 2005, pp. 759-763.http://dx.doi.org/10.1007/s10529-005-5628-7
---------- VANCOUVER ----------
Trelles, J.A., Valino, A.L., Runza, V., Lewkowicz, E.S., Iribarren, A.M. Screening of catalytically active microorganisms for the synthesis of 6-modified purine nucleosides. Biotechnol. Lett. 2005;27(11):759-763.http://dx.doi.org/10.1007/s10529-005-5628-7
