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Abstract:

Chemoenzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol was achieved by esterification of 1-O-hexadecyl-sn-glycerol, with palmitic acid in the presence of N,N-dicyclohexylcarbodiimide, and then subjected to alcoholysis catalysed by an immobilized 1,3-specific lipase. The highest yield (90% from 0.3 mM) was obtained in 3 h, using methyl isobutyl ketone as solvent with water activity 0.2.

Registro:

Documento: Artículo
Título:Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol
Autor:Salto, M.L.; Bertello, L.E.; De Lederkremer, R.M.
Filiación:Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina
Palabras clave:4 methyl 2 pentanone; dicyclohexylcarbodiimide; glycerol derivative; palmitic acid; solvent; triacylglycerol lipase; article; enzyme immobilization; esterification; synthesis; time
Año:1997
Volumen:19
Número:9
Página de inicio:853
Página de fin:855
DOI: http://dx.doi.org/10.1023/A:1018377318338
Título revista:Biotechnology Letters
Título revista abreviado:BIOTECHNOL. LETT.
ISSN:01415492
CODEN:BILED
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v19_n9_p853_Salto

Referencias:

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Citas:

---------- APA ----------
Salto, M.L., Bertello, L.E. & De Lederkremer, R.M. (1997) . Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol. Biotechnology Letters, 19(9), 853-855.
http://dx.doi.org/10.1023/A:1018377318338
---------- CHICAGO ----------
Salto, M.L., Bertello, L.E., De Lederkremer, R.M. "Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol" . Biotechnology Letters 19, no. 9 (1997) : 853-855.
http://dx.doi.org/10.1023/A:1018377318338
---------- MLA ----------
Salto, M.L., Bertello, L.E., De Lederkremer, R.M. "Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol" . Biotechnology Letters, vol. 19, no. 9, 1997, pp. 853-855.
http://dx.doi.org/10.1023/A:1018377318338
---------- VANCOUVER ----------
Salto, M.L., Bertello, L.E., De Lederkremer, R.M. Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol. BIOTECHNOL. LETT. 1997;19(9):853-855.
http://dx.doi.org/10.1023/A:1018377318338