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Vazquez-Levin, M.H.; Goldberg, S.I.; Friedmann, P.; Des Jarlais, D.C.; Nagler, H.M. "Papanicolaou and Kruger assessment of sperm morphology: Thresholds and agreement" (1998) International Journal of Andrology. 21(6):327-331
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Abstract:

The current World Health Organization guidelines suggest that the presence of ≥ 30% normal sperm forms (i.e. PAP criteria) is consistent with normal semen quality. Critical evaluation of sperm morphology (CE; Kruger classification) has shown an excellent correlation with human in vitro fertilization. Utilizing Kruger criteria, > 14% normal sperm forms has been proposed as indicative of normal semen quality. We have performed a retrospective analysis on 261 individuals to assess the agreement between PAP and Kruger criteria for normal sperm morphology (NSM). When the threshold for NSM by PAP was set at 30%, a significant agreement was found between the percentage normal forms of both criteria (Kappa coefficient = 0.37; p < 0.001). Sixty-seven (92%) of the 73 men found to have abnormal sperm morphology by PAP had abnormal semen by Kruger classification. When the threshold for NSM by PAP was established at 50%, the Kappa coefficient was 0.48 (p < 0.001). Sixty of the 72 samples (83%) classified as normal by PAP staining were normal by Kruger criteria. Interestingly, when NSM by PAP was between 30 and 50%, the specimen was just as likely to have normal or abnormal sperm morphology by Kruger (40 vs. 60%, respectively). These results strongly suggest that a high or low percentage of NSM by PAP is in agreement with the Kruger classification. The excellent agreement of Kruger and WHO criteria at the extremes (< 30% and > 50%) may obviate the need for Kruger assessment. However, when WHO morphology is between 30 and 50%, the addition of Kruger evaluation may provide meaningful information to help better diagnose a patient and plan his treatment.

Registro:

Documento: Artículo
Título:Papanicolaou and Kruger assessment of sperm morphology: Thresholds and agreement
Autor:Vazquez-Levin, M.H.; Goldberg, S.I.; Friedmann, P.; Des Jarlais, D.C.; Nagler, H.M.
Filiación:Department of Urology, Beth Israel Medical Center, New York, NY 10003, United States
Dept. of Grants Mgmt. and Res. Coop., Beth Israel Medical Center, New York, NY 10003, United States
Inst. de Biol. y Med. Experimental, Vuelta de Obligado 2490, 1428-Buenos Aires, Argentina
Palabras clave:Kruger classification; Sperm morphology; WHO criteria; article; cell structure; classification; comparative study; evaluation; fertilization in vitro; human; human cell; major clinical study; male; Papanicolaou test; practice guideline; priority journal; retrospective study; sperm; statistical analysis; world health organization; Humans; Male; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Spermatozoa
Año:1998
Volumen:21
Número:6
Página de inicio:327
Página de fin:331
DOI: http://dx.doi.org/10.1046/j.1365-2605.1998.00129.x
Título revista:International Journal of Andrology
Título revista abreviado:Int. J. Androl.
ISSN:01056263
CODEN:IJAND
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01056263_v21_n6_p327_VazquezLevin

Referencias:

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Citas:

---------- APA ----------
Vazquez-Levin, M.H., Goldberg, S.I., Friedmann, P., Des Jarlais, D.C. & Nagler, H.M. (1998) . Papanicolaou and Kruger assessment of sperm morphology: Thresholds and agreement. International Journal of Andrology, 21(6), 327-331.
http://dx.doi.org/10.1046/j.1365-2605.1998.00129.x
---------- CHICAGO ----------
Vazquez-Levin, M.H., Goldberg, S.I., Friedmann, P., Des Jarlais, D.C., Nagler, H.M. "Papanicolaou and Kruger assessment of sperm morphology: Thresholds and agreement" . International Journal of Andrology 21, no. 6 (1998) : 327-331.
http://dx.doi.org/10.1046/j.1365-2605.1998.00129.x
---------- MLA ----------
Vazquez-Levin, M.H., Goldberg, S.I., Friedmann, P., Des Jarlais, D.C., Nagler, H.M. "Papanicolaou and Kruger assessment of sperm morphology: Thresholds and agreement" . International Journal of Andrology, vol. 21, no. 6, 1998, pp. 327-331.
http://dx.doi.org/10.1046/j.1365-2605.1998.00129.x
---------- VANCOUVER ----------
Vazquez-Levin, M.H., Goldberg, S.I., Friedmann, P., Des Jarlais, D.C., Nagler, H.M. Papanicolaou and Kruger assessment of sperm morphology: Thresholds and agreement. Int. J. Androl. 1998;21(6):327-331.
http://dx.doi.org/10.1046/j.1365-2605.1998.00129.x