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Abstract:

The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the entire life-span of T cells including T-cell development, homing, activation, and differentiation. Galectin-1, an endogenous glycan-binding protein widely expressed at sites of inflammation and tumor growth, controls a diversity of immune cell processes, acting either extracellularly through specific binding to cell surface glycan structures or intracellularly through modulation of pathways that remain largely unexplored. In this review, we highlight the discoveries that have led to our current understanding of the role of galectin-1 in distinct immune cell process, particularly those associated with T-cell homeostasis. Also, we emphasize findings emerging from the study of experimental models of autoimmunity, chronic inflammation, fetomaternal tolerance, and tumor growth, which have provided fundamental insights into the critical role of galectin-1 and its specific saccharide ligands in immunoregulation. Challenges for the future will embrace the rational manipulation of galectin-1-glycan interactions both towards attenuating immune responses in autoimmune diseases, graft rejection, and recurrent fetal loss, while at the same overcoming immune tolerance in chronic infections and cancer. © 2009 John Wiley & Sons A/S.

Registro:

Documento: Artículo
Título:Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments
Autor:Rabinovich, G.A.; Ilarregui, J.M.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Ciudad de Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, C1428 Ciudad de Buenos Aires, Argentina
Palabras clave:Autoimmunity; Galectin-1; Glycosylation; Inflammation; Tolerance; Tumor-immune escape; carbohydrate; cell surface protein; cytokine; galectin 1; glycan; ligand; T lymphocyte receptor; adaptive immunity; apoptosis; autoimmune disease; autoimmunity; CD25+ T lymphocyte; CD4+ T lymphocyte; cell activation; cell differentiation; cell function; cell homing; cell migration; cell survival; chronic inflammation; cytokine release; homeostasis; human; immune response; immune system; immunoregulation; inflammation; innate immunity; macrophage; monocyte; neoplasm; nonhuman; pregnancy; priority journal; protein binding; protein carbohydrate interaction; protein expression; protein function; regulatory T lymphocyte; review; signal transduction; T lymphocyte; Th1 cell; Th2 cell; tumor; tumor growth; Animals; Cell Adhesion; Cell Movement; Cell Survival; Cytokines; Galectin 1; Homeostasis; Humans; Inflammation; Lymphocyte Activation; Neoplasms; Polysaccharides; Signal Transduction; T-Lymphocyte Subsets
Año:2009
Volumen:230
Número:1
Página de inicio:144
Página de fin:159
DOI: http://dx.doi.org/10.1111/j.1600-065X.2009.00787.x
Título revista:Immunological Reviews
Título revista abreviado:Immunol. Rev.
ISSN:01052896
CODEN:IMRED
CAS:galectin 1, 258495-34-0; Cytokines; Galectin 1; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01052896_v230_n1_p144_Rabinovich

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Citas:

---------- APA ----------
Rabinovich, G.A. & Ilarregui, J.M. (2009) . Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments. Immunological Reviews, 230(1), 144-159.
http://dx.doi.org/10.1111/j.1600-065X.2009.00787.x
---------- CHICAGO ----------
Rabinovich, G.A., Ilarregui, J.M. "Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments" . Immunological Reviews 230, no. 1 (2009) : 144-159.
http://dx.doi.org/10.1111/j.1600-065X.2009.00787.x
---------- MLA ----------
Rabinovich, G.A., Ilarregui, J.M. "Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments" . Immunological Reviews, vol. 230, no. 1, 2009, pp. 144-159.
http://dx.doi.org/10.1111/j.1600-065X.2009.00787.x
---------- VANCOUVER ----------
Rabinovich, G.A., Ilarregui, J.M. Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments. Immunol. Rev. 2009;230(1):144-159.
http://dx.doi.org/10.1111/j.1600-065X.2009.00787.x