Abstract:
We report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by 1H and 13C NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme. © 2010 Sociedade Brasileira de Química.
Registro:
Documento: |
Artículo
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Título: | Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives |
Autor: | Scorzo, C.M.; Fascio, M.L.; D'Accorso, N.B.; Cabrerab, M.G.; Saavedrab, L.A. |
Filiación: | CIHIDECAR-CONICET, Departamento de Química Orgànica, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina Laboratorio de Síntesis Orgànica, Instituto de Química de Productos Naturales, Universidad de Talca, Casilla 747, Talca, Chile
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Palabras clave: | Acetylcholinesterase; Alzheimeŕs disease; Cycloaddition; D-glyceraldehyde; Heterocyclic compounds |
Año: | 2010
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Volumen: | 21
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Número: | 1
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Página de inicio: | 43
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Página de fin: | 48
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DOI: |
http://dx.doi.org/10.1590/S0103-50532010000100008 |
Título revista: | Journal of the Brazilian Chemical Society
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Título revista abreviado: | J. Braz. Chem. Soc.
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ISSN: | 01035053
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CODEN: | JOCSE
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01035053_v21_n1_p43_Scorzo |
Referencias:
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Citas:
---------- APA ----------
Scorzo, C.M., Fascio, M.L., D'Accorso, N.B., Cabrerab, M.G. & Saavedrab, L.A.
(2010)
. Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives. Journal of the Brazilian Chemical Society, 21(1), 43-48.
http://dx.doi.org/10.1590/S0103-50532010000100008---------- CHICAGO ----------
Scorzo, C.M., Fascio, M.L., D'Accorso, N.B., Cabrerab, M.G., Saavedrab, L.A.
"Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives"
. Journal of the Brazilian Chemical Society 21, no. 1
(2010) : 43-48.
http://dx.doi.org/10.1590/S0103-50532010000100008---------- MLA ----------
Scorzo, C.M., Fascio, M.L., D'Accorso, N.B., Cabrerab, M.G., Saavedrab, L.A.
"Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives"
. Journal of the Brazilian Chemical Society, vol. 21, no. 1, 2010, pp. 43-48.
http://dx.doi.org/10.1590/S0103-50532010000100008---------- VANCOUVER ----------
Scorzo, C.M., Fascio, M.L., D'Accorso, N.B., Cabrerab, M.G., Saavedrab, L.A. Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives. J. Braz. Chem. Soc. 2010;21(1):43-48.
http://dx.doi.org/10.1590/S0103-50532010000100008