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Abstract:

A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.

Registro:

Documento: Artículo
Título:Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
Autor:Maldonado, H.; Romano, A.; Tomsic, D.
Filiación:Lab. Fisiol. Comportamiento Anim., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Biologia, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina
Laboratory of Adaptive Systems, NINDS, NIH Building 36, Bethesda, MD 20892, United States
Palabras clave:Angiotensin; Cycloheximide; Massed training; Memory; PKA; Spaced training; Chasmagnathus; Decapoda (Crustacea); Iti; animal; animal behavior; biological model; Brachyura; habituation; memory; physiology; review; Animals; Behavior, Animal; Brachyura; Habituation, Psychophysiologic; Memory; Models, Biological
Año:1997
Volumen:30
Número:7
Página de inicio:813
Página de fin:826
DOI: http://dx.doi.org/10.1590/S0100-879X1997000700001
Título revista:Brazilian Journal of Medical and Biological Research
Título revista abreviado:Braz. J. Med. Biol. Res.
ISSN:0100879X
CODEN:RBPMB
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0100879X_v30_n7_p813_Maldonado.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0100879X_v30_n7_p813_Maldonado

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Citas:

---------- APA ----------
Maldonado, H., Romano, A. & Tomsic, D. (1997) . Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory. Brazilian Journal of Medical and Biological Research, 30(7), 813-826.
http://dx.doi.org/10.1590/S0100-879X1997000700001
---------- CHICAGO ----------
Maldonado, H., Romano, A., Tomsic, D. "Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory" . Brazilian Journal of Medical and Biological Research 30, no. 7 (1997) : 813-826.
http://dx.doi.org/10.1590/S0100-879X1997000700001
---------- MLA ----------
Maldonado, H., Romano, A., Tomsic, D. "Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory" . Brazilian Journal of Medical and Biological Research, vol. 30, no. 7, 1997, pp. 813-826.
http://dx.doi.org/10.1590/S0100-879X1997000700001
---------- VANCOUVER ----------
Maldonado, H., Romano, A., Tomsic, D. Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory. Braz. J. Med. Biol. Res. 1997;30(7):813-826.
http://dx.doi.org/10.1590/S0100-879X1997000700001