Artículo

Farez, M.F.; Mascanfroni, I.D.; Méndez-Huergo, S.P.; Yeste, A.; Murugaiyan, G.; Garo, L.P.; Balbuena Aguirre, M.E.; Patel, B.; Ysrraelit, M.C.; Zhu, C.; Kuchroo, V.K.; Rabinovich, G.A.; Quintana, F.J.; Correale, J. "Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses" (2015) Cell. 162(6):1338-1352
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Abstract:

Summary Seasonal changes in disease activity have been observed in multiple sclerosis, an autoimmune disorder that affects the CNS. These epidemiological observations suggest that environmental factors influence the disease course. Here, we report that melatonin levels, whose production is modulated by seasonal variations in night length, negatively correlate with multiple sclerosis activity in humans. Treatment with melatonin ameliorates disease in an experimental model of multiple sclerosis and directly interferes with the differentiation of human and mouse T cells. Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-α. These results suggest that melatonin is another example of how environmental-driven cues can impact T cell differentiation and have implications for autoimmune disorders such as multiple sclerosis. © 2015 Elsevier Inc.

Registro:

Documento: Artículo
Título:Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses
Autor:Farez, M.F.; Mascanfroni, I.D.; Méndez-Huergo, S.P.; Yeste, A.; Murugaiyan, G.; Garo, L.P.; Balbuena Aguirre, M.E.; Patel, B.; Ysrraelit, M.C.; Zhu, C.; Kuchroo, V.K.; Rabinovich, G.A.; Quintana, F.J.; Correale, J.
Filiación:Center for Research on Neuroimmunological Diseases (CIEN), Raúl Carrea Institute for Neurological Research (FLENI), Buenos Aires, 1428, Argentina
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (IBYME-CONICET), Buenos Aires, 1428, Argentina
Department of Neurology, Hospital de Clínicas José de San Martín, Buenos Aires, 1428, Argentina
Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina
Palabras clave:CCAAT enhancer binding protein alpha; interleukin 10; melatonin; mitogen activated protein kinase 1; mitogen activated protein kinase 3; retinoid related orphan receptor alpha; retinoid related orphan receptor gamma; transcription factor; transcription factor Nfil3; unclassified drug; basic leucine zipper transcription factor; CCAAT enhancer binding protein; melatonin; retinoid related orphan receptor gamma; adult; animal cell; animal experiment; animal model; Article; autumn; cell differentiation; controlled study; disease activity; enzyme activation; experimental allergic encephalitis; female; human; human cell; major clinical study; male; mouse; multiple sclerosis; nonhuman; priority journal; protein expression; regulatory T lymphocyte; seasonal variation; Th17 cell; transactivation; winter; animal; C57BL mouse; cytology; experimental autoimmune encephalomyelitis; immunology; light; metabolism; multiple sclerosis; pathology; recurrent disease; season; signal transduction; Animals; Basic-Leucine Zipper Transcription Factors; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Light; Male; MAP Kinase Signaling System; Melatonin; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Nuclear Receptor Subfamily 1, Group F, Member 3; Recurrence; Seasons; T-Lymphocytes, Regulatory; Th17 Cells
Año:2015
Volumen:162
Número:6
Página de inicio:1338
Página de fin:1352
DOI: http://dx.doi.org/10.1016/j.cell.2015.08.025
Título revista:Cell
Título revista abreviado:Cell
ISSN:00928674
CODEN:CELLB
CAS:melatonin, 73-31-4; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Basic-Leucine Zipper Transcription Factors; CCAAT-Enhancer-Binding Proteins; Melatonin; Nuclear Receptor Subfamily 1, Group F, Member 3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928674_v162_n6_p1338_Farez

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Citas:

---------- APA ----------
Farez, M.F., Mascanfroni, I.D., Méndez-Huergo, S.P., Yeste, A., Murugaiyan, G., Garo, L.P., Balbuena Aguirre, M.E.,..., Correale, J. (2015) . Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell, 162(6), 1338-1352.
http://dx.doi.org/10.1016/j.cell.2015.08.025
---------- CHICAGO ----------
Farez, M.F., Mascanfroni, I.D., Méndez-Huergo, S.P., Yeste, A., Murugaiyan, G., Garo, L.P., et al. "Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses" . Cell 162, no. 6 (2015) : 1338-1352.
http://dx.doi.org/10.1016/j.cell.2015.08.025
---------- MLA ----------
Farez, M.F., Mascanfroni, I.D., Méndez-Huergo, S.P., Yeste, A., Murugaiyan, G., Garo, L.P., et al. "Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses" . Cell, vol. 162, no. 6, 2015, pp. 1338-1352.
http://dx.doi.org/10.1016/j.cell.2015.08.025
---------- VANCOUVER ----------
Farez, M.F., Mascanfroni, I.D., Méndez-Huergo, S.P., Yeste, A., Murugaiyan, G., Garo, L.P., et al. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015;162(6):1338-1352.
http://dx.doi.org/10.1016/j.cell.2015.08.025