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Abstract:

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced. © 2011 Elsevier Inc.

Registro:

Documento: Artículo
Título:Epigenetics in alternative pre-mRNA splicing
Autor:Luco, R.F.; Allo, M.; Schor, I.E.; Kornblihtt, A.R.; Misteli, T.
Filiación:National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States
Departamento de Fisiología Biología Molecular, LFBM and IFIBYNE-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:adenosine triphosphatase; fibroblast growth factor receptor 2; fibronectin; heterochromatin protein 1; heterogeneous nuclear ribonucleoprotein; histone 2a.v; histone 2a.x; histone 2a.z; histone H2A; histone methyltransferase; messenger RNA; nerve cell adhesion molecule; protein carm1; protein h3k27me2; protein h3k36me3; protein h3k4me3; protien e33; RNA polymerase II; small interfering RNA; small nuclear ribonucleoprotein; unclassified drug; alternative RNA splicing; binding site; chromatin assembly and disassembly; chromatin structure; DNA methylation; down regulation; epigenetics; gene expression; gene interaction; genetic association; genetic selection; genetic transcription; human; priority journal; protein modification; review; RNA degradation; RNA processing; RNA translation; transcription regulation; Alternative Splicing; Animals; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Histones; Humans; RNA Precursors; Transcription, Genetic; Eukaryota
Año:2011
Volumen:144
Número:1
Página de inicio:16
Página de fin:26
DOI: http://dx.doi.org/10.1016/j.cell.2010.11.056
Título revista:Cell
Título revista abreviado:Cell
ISSN:00928674
CODEN:CELLB
CAS:adenosine triphosphatase, 37289-25-1, 9000-83-3; fibronectin, 86088-83-7; Histones; RNA Precursors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928674_v144_n1_p16_Luco

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Citas:

---------- APA ----------
Luco, R.F., Allo, M., Schor, I.E., Kornblihtt, A.R. & Misteli, T. (2011) . Epigenetics in alternative pre-mRNA splicing. Cell, 144(1), 16-26.
http://dx.doi.org/10.1016/j.cell.2010.11.056
---------- CHICAGO ----------
Luco, R.F., Allo, M., Schor, I.E., Kornblihtt, A.R., Misteli, T. "Epigenetics in alternative pre-mRNA splicing" . Cell 144, no. 1 (2011) : 16-26.
http://dx.doi.org/10.1016/j.cell.2010.11.056
---------- MLA ----------
Luco, R.F., Allo, M., Schor, I.E., Kornblihtt, A.R., Misteli, T. "Epigenetics in alternative pre-mRNA splicing" . Cell, vol. 144, no. 1, 2011, pp. 16-26.
http://dx.doi.org/10.1016/j.cell.2010.11.056
---------- VANCOUVER ----------
Luco, R.F., Allo, M., Schor, I.E., Kornblihtt, A.R., Misteli, T. Epigenetics in alternative pre-mRNA splicing. Cell. 2011;144(1):16-26.
http://dx.doi.org/10.1016/j.cell.2010.11.056