Abstract:
We explore the dynamic behavior of a model of calcium oscillations and wave propagation in the basal region of pancreatic acinar cells [Sneyd, J., et al., Biophys. J. 85: 1392-1405, 2003]. Since it is known that two principal calcium release pathways are involved, inositol trisphosphate receptors (IPR) and ryanodine receptors (RyR), we study how the model behavior depends on the density of each receptor type. Calcium oscillations can be mediated either by IPR or RyR. Continuous increases in either RyR or IPR density can lead to the appearance and disappearance of oscillations multiple times, and the two receptor types interact via their common effect on cytoplasmic calcium concentration and the subsequent effect on the total amount of calcium inside the cell. Increases in agonist concentration can stimulate oscillations via the RyR by increasing calcium influx. Using a two time-scale approach, we explain these complex behaviors by treating the total amount of cellular calcium as a slow parameter. Oscillations are controlled by the shape of the slow manifold and where it intersects the nullcline of the slow variable. When calcium diffusion is included, the existence of traveling waves in the model equation is strongly dependent on the interplay between the total amount of calcium in the cell and membrane transport, a feature that can be experimentally tested. Our results help us understand the behavior of a model that includes both receptors in comparison to the properties of each receptor type in isolation. © 2006 Springer Science+Business Media, Inc.
Registro:
Documento: |
Artículo
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Título: | Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells |
Autor: | Ventura, A.C.; Sneyd, J. |
Filiación: | Departamento de Física, FCEyN, Universidad de Buenos Aires, Buenos Aires, Argentina Department of Mathematics, University of Auckland, Auckland, New Zealand
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Palabras clave: | Calcium oscillations; Calcium waves; Pancreatic acinar cells; Traveling waves; inositol 1,4,5 trisphosphate receptor; ryanodine receptor; article; biological model; calcium signaling; comparative study; human; metabolism; pancreas; physiology; Calcium Signaling; Humans; Inositol 1,4,5-Trisphosphate Receptors; Models, Biological; Pancreas; Ryanodine Receptor Calcium Release Channel |
Año: | 2006
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Volumen: | 68
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Número: | 8
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Página de inicio: | 2205
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Página de fin: | 2231
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DOI: |
http://dx.doi.org/10.1007/s11538-006-9101-0 |
Título revista: | Bulletin of Mathematical Biology
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Título revista abreviado: | Bull. Math. Biol.
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ISSN: | 00928240
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CODEN: | BMTBA
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CAS: | Inositol 1,4,5-Trisphosphate Receptors; Ryanodine Receptor Calcium Release Channel
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00928240_v68_n8_p2205_Ventura |
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Citas:
---------- APA ----------
Ventura, A.C. & Sneyd, J.
(2006)
. Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells. Bulletin of Mathematical Biology, 68(8), 2205-2231.
http://dx.doi.org/10.1007/s11538-006-9101-0---------- CHICAGO ----------
Ventura, A.C., Sneyd, J.
"Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells"
. Bulletin of Mathematical Biology 68, no. 8
(2006) : 2205-2231.
http://dx.doi.org/10.1007/s11538-006-9101-0---------- MLA ----------
Ventura, A.C., Sneyd, J.
"Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells"
. Bulletin of Mathematical Biology, vol. 68, no. 8, 2006, pp. 2205-2231.
http://dx.doi.org/10.1007/s11538-006-9101-0---------- VANCOUVER ----------
Ventura, A.C., Sneyd, J. Calcium oscillations and waves generated by multiple release mechanisms in pancreatic acinar cells. Bull. Math. Biol. 2006;68(8):2205-2231.
http://dx.doi.org/10.1007/s11538-006-9101-0