Abstract:
The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a hesperidin structural analog that exerts minor sedative effect, were able to induce changes in intracellular signaling cascades in different areas of the brain. The systemic administration of hesperidin produced a marked reduction in the phosphorylation state of extracellular signal-regulated kinases 1/2 (ERK 1/2), but not of Ca+2/calmodulin-dependent protein kinase II α subunit (αCaMKII), in the cerebral cortex, cerebellum and hippocampus. In contrast, neo-hesperidin did not markedly affect the activity of ERK 1/2 in both the cortex and the cerebellum. Taken together, these results demonstrated that intracellular signalling involving a selective decrease in ERK1/2 activation accompanied the depressant action of hesperidin. Even more, the low sedative action of neo-hesperidin correlates with a negligible decrease in phosphorylation state of ERK 1/2 (pERK 1/2), suggesting that low levels of pERK 1/2 in CNS could be a marker of sedative efficacy of flavonoids. © 2008 Elsevier Inc. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice |
Autor: | Martínez, M.C.; Fernandez, S.P.; Loscalzo, L.M.; Wasowski, C.; Paladini, A.C.; Marder, M.; Medina, J.H.; Viola, H. |
Filiación: | Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3 Piso, C1121ABG, Argentina Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 6 Piso, C1113AAD, Argentina Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Guiraldes 2160, 2 piso, Pabellon II, Argentina
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Palabras clave: | Hesperidin; Mouse; pαCaMKII; pERK 1/2; Sedation; calcium calmodulin dependent protein kinase; calcium calmodulin dependent protein kinase ii alpha; drug vehicle; flavonoid glycoside; hesperidin; mitogen activated protein kinase 1; mitogen activated protein kinase 3; neohesperidin; unclassified drug; animal cell; animal experiment; animal model; animal tissue; article; brain cortex; cerebellum; controlled study; depression; drug efficacy; enzyme inactivation; enzyme phosphorylation; intracellular transport; locomotion; male; mouse; nonhuman; priority journal; sedation; Animals; Behavior, Animal; Brain; Hesperidin; Hypnotics and Sedatives; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Signal Transduction; Mus |
Año: | 2009
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Volumen: | 92
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Número: | 2
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Página de inicio: | 291
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Página de fin: | 296
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DOI: |
http://dx.doi.org/10.1016/j.pbb.2008.12.016 |
Título revista: | Pharmacology Biochemistry and Behavior
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Título revista abreviado: | Pharmacol. Biochem. Behav.
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ISSN: | 00913057
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CODEN: | PBBHA
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CAS: | calcium calmodulin dependent protein kinase, 97350-82-8; hesperidin, 520-26-3; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Hesperidin, 520-26-3; Hypnotics and Sedatives; Mitogen-Activated Protein Kinase 1, 2.7.1.37; Mitogen-Activated Protein Kinase 3, 2.7.1.37
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v92_n2_p291_Martinez |
Referencias:
- Abou-Shoer, M., Ma, G.E., Li, X.H., Koonchanok, N.M., Geahlen, R.L., Chang, C.J., Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors (1993) J Nat Prod, 56, pp. 967-969
- Agullo, G., Gamet-Payrastre, L., Manenti, S., Viala, C., Remesy, C., Chap, H., Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition (1997) Biochem Pharmacol, 53, pp. 1649-1657
- Ailing, F., Fan, L., Li, S., Manji, S., Role of extracellular signal-regulated kinase signal transduction pathway in anxiety (2008) J Psychiatr Res
- Cammarota, M., Bevilaqua, L.R., Ardenghi, P., Paratcha, G., Levi de Stein, M., Izquierdo, I., Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade (2000) Brain Res Mol Brain Res, 76, pp. 36-46
- Chang, B.H., Mukherji, S., Soderling, T.R., Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain (2001) Neuroscience, 102, pp. 767-777
- Chung, J.Y., Park, J.O., Phyu, H., Dong, Z., Yang, C.S., Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate (2001) Faseb J, 15, pp. 2022-2024
- Dietz, B.M., Mahady, G.B., Pauli, G.F., Farnsworth, N.R., Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro (2005) Brain Res Mol Brain Res, 138, pp. 191-197
- Eitan, S., Bryant, C.D., Saliminejad, N., Yang, Y.C., Vojdani, E., Keith Jr., D., Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization (2003) J Neurosci, 23, pp. 8360-8369
- Fernandez, S.P., Wasowski, C., Paladini, A.C., Marder, M., Synergistic interaction between hesperidin, a natural flavonoid, and diazepam (2005) Eur J Pharmacol, 512, pp. 189-198
- Fernandez, S.P., Wasowski, C., Loscalzo, L.M., Granger, R.E., Johnston, G.A., Paladini, A.C., Central nervous system depressant action of flavonoid glycosides (2006) Eur J Pharmacol, 539, pp. 168-176
- File, S.E., Pellow, S., The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard (1985) Br J Pharmacol, 86, pp. 729-735
- Gutstein, H.B., Rubie, E.A., Mansour, A., Akil, H., Woodgett, J.R., Opioid effects on mitogen-activated protein kinase signaling cascades (1997) Anesthesiology, 87, pp. 1118-1126
- Hagiwara, M., Inoue, S., Tanaka, T., Nunoki, K., Ito, M., Hidaka, H., Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases (1988) Biochem Pharmacol, 37, pp. 2987-2992
- Houghton, P.J., The scientific basis for the reputed activity of Valerian (1999) J Pharm Pharmacol, 51, pp. 505-512
- Hwang, S.L., Yen, G.C., Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells (2008) J Agric Food Chem, 56, pp. 859-864
- Kalluri, H.S., Ticku, M.K., Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase (2002) Eur J Pharmacol, 451, pp. 51-54
- Kalluri, H.S., Ticku, M.K., Ethanol-mediated inhibition of mitogen-activated protein kinase phosphorylation in mouse brain (2002) Eur J Pharmacol, 439, pp. 53-58
- Khan, N., Afaq, F., Saleem, M., Ahmad, N., Mukhtar, H., Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate (2006) Cancer Res, 66, pp. 2500-2505
- Kobuchi, H., Roy, S., Sen, C.K., Nguyen, H.G., Packer, L., Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway (1999) Am J Physiol, 277, pp. C403-411
- Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines (2008) Eur J Pharmacol, 580, pp. 306-313
- Marder, M., Viola, H., Wasowski, C., Fernandez, S., Medina, J.H., Paladini, A.C., 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS (2003) Pharmacol Biochem Behav, 75, pp. 537-545
- Medina, J.H., Pena, C., Levi de Stein, M., Wolfman, C., Paladini, A., Benzodiazepine-like molecules as well as other ligands from the brain for the brain benzodiazepine receptor are relatively common constituents of plants (1998) Biochem Biophys Res Commun, 165, pp. 547-555
- Morozov, A., Muzzio, I.A., Bourtchouladze, R., Van-Strien, N., Lapidus, K., Yin, D., Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory (2003) Neuron, 39, pp. 309-325
- Neuhaus, T., Pabst, S., Stier, S., Weber, A.A., Schror, K., Sachinidis, A., Inhibition of the vascular-endothelial growth factor-induced intracellular signaling and mitogenesis of human endothelial cells by epigallocatechin-3 gallate (2004) Eur J Pharmacol, 483, pp. 223-227
- Rainey-Smith, S., Schroetke, L.W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J.P., Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation (2008) Neurosci Lett, 438, pp. 29-33
- Reynolds, J., (1996) Martindale: the extra pharmacopeia. 31st edition, , The Pharmaceutical Press, London
- Sah, J.F., Balasubramanian, S., Eckert, R.L., Rorke, E.A., Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases (2004) J Biol Chem, 279, pp. 12755-12762
- Schroeter, H., Boyd, C., Spencer, J.P., Williams, R.J., Cadenas, E., Rice-Evans, C., MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide (2002) Neurobiol Aging, 23, pp. 861-880
- Schulz, S., Hollt, V., Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine-dependent rats in vivo (1998) Eur J Neurosci, 10, pp. 1196-1201
- Serra, H., Mendes, T., Bronze, M.R., Simplicio, A.L., Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones (2008) Bioorg Med Chem, 16, pp. 4009-4018
- Spencer, J.P., Rice-Evans, C., Williams, R.J., Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability (2003) J Biol Chem, 278, pp. 34783-34793
- Sweatt, J.D., The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory (2001) J Neurochem, 76, pp. 1-10
- Thomas, G.M., Huganir, R.L., MAPK cascade signalling and synaptic plasticity (2004) Nat Rev Neurosci, 5, pp. 173-183
- Valjent, E., Pages, C., Herve, D., Girault, J.A., Caboche, J., Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain (2004) Eur J Neurosci, 19, pp. 1826-1836
- Vauzour, D., Vafeiadou, K., Rice-Evans, C., Williams, R.J., Spencer, J.P., Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons (2007) J Neurochem, 103, pp. 1355-1367
- Vignes, M., Maurice, T., Lante, F., Nedjar, M., Thethi, K., Guiramand, J., Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG) (2006) Brain Res, 1110, pp. 102-115
- Viola, H., Wolfman, C., Levi de Stein, M., Wasowski, C., Pena, C., Medina, J.H., Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae) (1994) J Ethnopharmacol, 44, pp. 47-53
- Viola, H., Wasowski, C., Levi de Stein, M., Wolfman, C., Silveira, R., Dajas, F., Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects (1995) Planta Med, 61, pp. 213-216
- Viola, H., Wasowski, C., Marder, M., Wolfman, C., Paladini, A., Medina, J.H., Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, cirsiliol (1997) Phytomedicine, 4, pp. 45-50
- Wasowski, C., Marder, M., Viola, H., Medina, J.H., Paladini, A.C., Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii (2002) Planta Med, 68, pp. 934-936
- Wolfman, C., Viola, H., Paladini, A., Dajas, F., Medina, J.H., Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea (1994) Pharmacol Biochem Behav, 47, pp. 1-4
- Youdim, K.A., Dobbie, M.S., Kuhnle, G., Proteggente, A.R., Abbott, N.J., Rice-Evans, C., Interaction between flavonoids and the blood-brain barrier: in vitro studies (2003) J Neurochem, 85, pp. 180-192
Citas:
---------- APA ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., Medina, J.H.,..., Viola, H.
(2009)
. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacology Biochemistry and Behavior, 92(2), 291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016---------- CHICAGO ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., et al.
"Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice"
. Pharmacology Biochemistry and Behavior 92, no. 2
(2009) : 291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016---------- MLA ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., et al.
"Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice"
. Pharmacology Biochemistry and Behavior, vol. 92, no. 2, 2009, pp. 291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016---------- VANCOUVER ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., et al. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol. Biochem. Behav. 2009;92(2):291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016