Artículo

Martínez, M.C.; Fernandez, S.P.; Loscalzo, L.M.; Wasowski, C.; Paladini, A.C.; Marder, M.; Medina, J.H.; Viola, H. "Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice" (2009) Pharmacology Biochemistry and Behavior. 92(2):291-296
La versión final de este artículo es de uso interno de la institución.
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The aim of this work was to evaluate if the intraperitoneal administration of the natural compound hesperidin, in a sedative dose, and neo-hesperidin, a hesperidin structural analog that exerts minor sedative effect, were able to induce changes in intracellular signaling cascades in different areas of the brain. The systemic administration of hesperidin produced a marked reduction in the phosphorylation state of extracellular signal-regulated kinases 1/2 (ERK 1/2), but not of Ca+2/calmodulin-dependent protein kinase II α subunit (αCaMKII), in the cerebral cortex, cerebellum and hippocampus. In contrast, neo-hesperidin did not markedly affect the activity of ERK 1/2 in both the cortex and the cerebellum. Taken together, these results demonstrated that intracellular signalling involving a selective decrease in ERK1/2 activation accompanied the depressant action of hesperidin. Even more, the low sedative action of neo-hesperidin correlates with a negligible decrease in phosphorylation state of ERK 1/2 (pERK 1/2), suggesting that low levels of pERK 1/2 in CNS could be a marker of sedative efficacy of flavonoids. © 2008 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
Autor:Martínez, M.C.; Fernandez, S.P.; Loscalzo, L.M.; Wasowski, C.; Paladini, A.C.; Marder, M.; Medina, J.H.; Viola, H.
Filiación:Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 3 Piso, C1121ABG, Argentina
Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 6 Piso, C1113AAD, Argentina
Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Guiraldes 2160, 2 piso, Pabellon II, Argentina
Palabras clave:Hesperidin; Mouse; pαCaMKII; pERK 1/2; Sedation; calcium calmodulin dependent protein kinase; calcium calmodulin dependent protein kinase ii alpha; drug vehicle; flavonoid glycoside; hesperidin; mitogen activated protein kinase 1; mitogen activated protein kinase 3; neohesperidin; unclassified drug; animal cell; animal experiment; animal model; animal tissue; article; brain cortex; cerebellum; controlled study; depression; drug efficacy; enzyme inactivation; enzyme phosphorylation; intracellular transport; locomotion; male; mouse; nonhuman; priority journal; sedation; Animals; Behavior, Animal; Brain; Hesperidin; Hypnotics and Sedatives; Male; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Signal Transduction; Mus
Año:2009
Volumen:92
Número:2
Página de inicio:291
Página de fin:296
DOI: http://dx.doi.org/10.1016/j.pbb.2008.12.016
Título revista:Pharmacology Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
ISSN:00913057
CODEN:PBBHA
CAS:calcium calmodulin dependent protein kinase, 97350-82-8; hesperidin, 520-26-3; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Hesperidin, 520-26-3; Hypnotics and Sedatives; Mitogen-Activated Protein Kinase 1, 2.7.1.37; Mitogen-Activated Protein Kinase 3, 2.7.1.37
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v92_n2_p291_Martinez

Referencias:

  • Abou-Shoer, M., Ma, G.E., Li, X.H., Koonchanok, N.M., Geahlen, R.L., Chang, C.J., Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors (1993) J Nat Prod, 56, pp. 967-969
  • Agullo, G., Gamet-Payrastre, L., Manenti, S., Viala, C., Remesy, C., Chap, H., Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition (1997) Biochem Pharmacol, 53, pp. 1649-1657
  • Ailing, F., Fan, L., Li, S., Manji, S., Role of extracellular signal-regulated kinase signal transduction pathway in anxiety (2008) J Psychiatr Res
  • Cammarota, M., Bevilaqua, L.R., Ardenghi, P., Paratcha, G., Levi de Stein, M., Izquierdo, I., Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade (2000) Brain Res Mol Brain Res, 76, pp. 36-46
  • Chang, B.H., Mukherji, S., Soderling, T.R., Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain (2001) Neuroscience, 102, pp. 767-777
  • Chung, J.Y., Park, J.O., Phyu, H., Dong, Z., Yang, C.S., Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate (2001) Faseb J, 15, pp. 2022-2024
  • Dietz, B.M., Mahady, G.B., Pauli, G.F., Farnsworth, N.R., Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro (2005) Brain Res Mol Brain Res, 138, pp. 191-197
  • Eitan, S., Bryant, C.D., Saliminejad, N., Yang, Y.C., Vojdani, E., Keith Jr., D., Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization (2003) J Neurosci, 23, pp. 8360-8369
  • Fernandez, S.P., Wasowski, C., Paladini, A.C., Marder, M., Synergistic interaction between hesperidin, a natural flavonoid, and diazepam (2005) Eur J Pharmacol, 512, pp. 189-198
  • Fernandez, S.P., Wasowski, C., Loscalzo, L.M., Granger, R.E., Johnston, G.A., Paladini, A.C., Central nervous system depressant action of flavonoid glycosides (2006) Eur J Pharmacol, 539, pp. 168-176
  • File, S.E., Pellow, S., The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard (1985) Br J Pharmacol, 86, pp. 729-735
  • Gutstein, H.B., Rubie, E.A., Mansour, A., Akil, H., Woodgett, J.R., Opioid effects on mitogen-activated protein kinase signaling cascades (1997) Anesthesiology, 87, pp. 1118-1126
  • Hagiwara, M., Inoue, S., Tanaka, T., Nunoki, K., Ito, M., Hidaka, H., Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases (1988) Biochem Pharmacol, 37, pp. 2987-2992
  • Houghton, P.J., The scientific basis for the reputed activity of Valerian (1999) J Pharm Pharmacol, 51, pp. 505-512
  • Hwang, S.L., Yen, G.C., Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells (2008) J Agric Food Chem, 56, pp. 859-864
  • Kalluri, H.S., Ticku, M.K., Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase (2002) Eur J Pharmacol, 451, pp. 51-54
  • Kalluri, H.S., Ticku, M.K., Ethanol-mediated inhibition of mitogen-activated protein kinase phosphorylation in mouse brain (2002) Eur J Pharmacol, 439, pp. 53-58
  • Khan, N., Afaq, F., Saleem, M., Ahmad, N., Mukhtar, H., Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate (2006) Cancer Res, 66, pp. 2500-2505
  • Kobuchi, H., Roy, S., Sen, C.K., Nguyen, H.G., Packer, L., Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway (1999) Am J Physiol, 277, pp. C403-411
  • Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines (2008) Eur J Pharmacol, 580, pp. 306-313
  • Marder, M., Viola, H., Wasowski, C., Fernandez, S., Medina, J.H., Paladini, A.C., 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS (2003) Pharmacol Biochem Behav, 75, pp. 537-545
  • Medina, J.H., Pena, C., Levi de Stein, M., Wolfman, C., Paladini, A., Benzodiazepine-like molecules as well as other ligands from the brain for the brain benzodiazepine receptor are relatively common constituents of plants (1998) Biochem Biophys Res Commun, 165, pp. 547-555
  • Morozov, A., Muzzio, I.A., Bourtchouladze, R., Van-Strien, N., Lapidus, K., Yin, D., Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory (2003) Neuron, 39, pp. 309-325
  • Neuhaus, T., Pabst, S., Stier, S., Weber, A.A., Schror, K., Sachinidis, A., Inhibition of the vascular-endothelial growth factor-induced intracellular signaling and mitogenesis of human endothelial cells by epigallocatechin-3 gallate (2004) Eur J Pharmacol, 483, pp. 223-227
  • Rainey-Smith, S., Schroetke, L.W., Bahia, P., Fahmi, A., Skilton, R., Spencer, J.P., Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation (2008) Neurosci Lett, 438, pp. 29-33
  • Reynolds, J., (1996) Martindale: the extra pharmacopeia. 31st edition, , The Pharmaceutical Press, London
  • Sah, J.F., Balasubramanian, S., Eckert, R.L., Rorke, E.A., Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases (2004) J Biol Chem, 279, pp. 12755-12762
  • Schroeter, H., Boyd, C., Spencer, J.P., Williams, R.J., Cadenas, E., Rice-Evans, C., MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide (2002) Neurobiol Aging, 23, pp. 861-880
  • Schulz, S., Hollt, V., Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine-dependent rats in vivo (1998) Eur J Neurosci, 10, pp. 1196-1201
  • Serra, H., Mendes, T., Bronze, M.R., Simplicio, A.L., Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones (2008) Bioorg Med Chem, 16, pp. 4009-4018
  • Spencer, J.P., Rice-Evans, C., Williams, R.J., Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability (2003) J Biol Chem, 278, pp. 34783-34793
  • Sweatt, J.D., The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory (2001) J Neurochem, 76, pp. 1-10
  • Thomas, G.M., Huganir, R.L., MAPK cascade signalling and synaptic plasticity (2004) Nat Rev Neurosci, 5, pp. 173-183
  • Valjent, E., Pages, C., Herve, D., Girault, J.A., Caboche, J., Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain (2004) Eur J Neurosci, 19, pp. 1826-1836
  • Vauzour, D., Vafeiadou, K., Rice-Evans, C., Williams, R.J., Spencer, J.P., Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons (2007) J Neurochem, 103, pp. 1355-1367
  • Vignes, M., Maurice, T., Lante, F., Nedjar, M., Thethi, K., Guiramand, J., Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG) (2006) Brain Res, 1110, pp. 102-115
  • Viola, H., Wolfman, C., Levi de Stein, M., Wasowski, C., Pena, C., Medina, J.H., Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae) (1994) J Ethnopharmacol, 44, pp. 47-53
  • Viola, H., Wasowski, C., Levi de Stein, M., Wolfman, C., Silveira, R., Dajas, F., Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects (1995) Planta Med, 61, pp. 213-216
  • Viola, H., Wasowski, C., Marder, M., Wolfman, C., Paladini, A., Medina, J.H., Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, cirsiliol (1997) Phytomedicine, 4, pp. 45-50
  • Wasowski, C., Marder, M., Viola, H., Medina, J.H., Paladini, A.C., Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii (2002) Planta Med, 68, pp. 934-936
  • Wolfman, C., Viola, H., Paladini, A., Dajas, F., Medina, J.H., Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea (1994) Pharmacol Biochem Behav, 47, pp. 1-4
  • Youdim, K.A., Dobbie, M.S., Kuhnle, G., Proteggente, A.R., Abbott, N.J., Rice-Evans, C., Interaction between flavonoids and the blood-brain barrier: in vitro studies (2003) J Neurochem, 85, pp. 180-192

Citas:

---------- APA ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., Medina, J.H.,..., Viola, H. (2009) . Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacology Biochemistry and Behavior, 92(2), 291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016
---------- CHICAGO ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., et al. "Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice" . Pharmacology Biochemistry and Behavior 92, no. 2 (2009) : 291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016
---------- MLA ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., et al. "Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice" . Pharmacology Biochemistry and Behavior, vol. 92, no. 2, 2009, pp. 291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016
---------- VANCOUVER ----------
Martínez, M.C., Fernandez, S.P., Loscalzo, L.M., Wasowski, C., Paladini, A.C., Marder, M., et al. Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice. Pharmacol. Biochem. Behav. 2009;92(2):291-296.
http://dx.doi.org/10.1016/j.pbb.2008.12.016