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A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cycloheximide sensitive, correlated with PKA activity and NFκ-B activation, positively modulated by angiotensins, and selectively regulated by a muscarinic-cholinergic mechanism. The present research was aimed at studying the possible involvement of NMDA-like receptors in CSM, given the role attributed to these receptors in vertebrate memory and their occurrence in invertebrates including crustaceans. Vertebrate antagonists (±)-2-amino-5-phosphonopentanoic acid (AP5) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) were used. Memory retention impairment was shown with MK-801 10-3 M (1 μg/g) injected immediately before training or after training, or delayed 1 or 4 h, but not 6 h, posttraining. An AP5 10-3 M dose (0.6 μg/g) impairs retention when given before but not after training. Neither antagonist produced retrieval deficit. A memory process similar to CSM but nonassociative in nature and induced by massed training (termed signal memory, SM), proved entirely insensitive to AP5 or MK-801, confirming the view that distinct mechanisms subserve these different types of memory in the crab. © 2002 Elsevier Science Inc. All rights reserved.


Documento: Artículo
Título:Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
Autor:Troncoso, J.; Maldonado, H.
Filiación:Laboratorio de Neurobiología de la Memoria, Facultad de Ciencias Exactas y Naturales, Departamento Biologia, Universidad de Buenos Aires, Buenos Aires, Argentina
Biologia, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:AP5: MK-801; Crab; Crustacea; Learning; Memory; NMDA; 2 amino 5 phosphonovaleric acid; angiotensin; cyclic AMP dependent protein kinase; cycloheximide; dizocilpine; immunoglobulin enhancer binding protein; n methyl dextro aspartic acid receptor; n methyl dextro aspartic acid receptor blocking agent; amino acid receptor blocking agent; n methyl dextro aspartic acid receptor; amnesia; article; associative memory; controlled study; crab; Crustacea; dose response; drug effect; environment; enzyme activity; male; memory; memory consolidation; nonhuman; priority journal; stimulus; training; animal; Brachyura; comparative study; drug antagonism; physiology; Chasmagnathus; Crustacea; Decapoda (Crustacea); Invertebrata; Vertebrata; Animals; Brachyura; Excitatory Amino Acid Antagonists; Male; Memory; Receptors, N-Methyl-D-Aspartate
Página de inicio:251
Página de fin:265
Título revista:Pharmacology Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
CAS:Excitatory Amino Acid Antagonists; Receptors, N-Methyl-D-Aspartate


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---------- APA ----------
Troncoso, J. & Maldonado, H. (2002) . Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists. Pharmacology Biochemistry and Behavior, 72(1-2), 251-265.
---------- CHICAGO ----------
Troncoso, J., Maldonado, H. "Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists" . Pharmacology Biochemistry and Behavior 72, no. 1-2 (2002) : 251-265.
---------- MLA ----------
Troncoso, J., Maldonado, H. "Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists" . Pharmacology Biochemistry and Behavior, vol. 72, no. 1-2, 2002, pp. 251-265.
---------- VANCOUVER ----------
Troncoso, J., Maldonado, H. Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists. Pharmacol. Biochem. Behav. 2002;72(1-2):251-265.