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Abstract:

On sudden presentation of a passing shadow a visual danger stimulus), the crab Chasmagnathus granulatus responds with a running reaction that we term an escape response (ER). A single administration of 5-HT in a dose range between 0.005 and 0.1 μg/g enhances the ER at 30 min, and a dose of 10-15 μg/g has a similar effect for at least 24 h. The classical 5-HT antagonist cyproheptadine (CYP) given within a dose range 0.01-2.0 μg/g has no effect on ER at 30 min, but 0.5 μg/g blocks the 5-HT-induced short-term sensitization. An enhancing effect of CYP on the ER is shown at 24 h with 1.0-2.0 μg/g doses. An explanation of this results in terms of a model similar to that proposed for Aplysia, that is two sensitizing processes linked in parallel and mediated by two different types of 5-HT receptors is discussed. Results indicate that the sensitizing effect of 5-HT is confined to high responders, thus suggesting that crabs of a same population have different degrees of sensitivity to the drug according to their different degrees of reactivity to the visual danger stimulus.

Registro:

Documento: Artículo
Título:Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus
Autor:Aggio, J.; Rakitín, A.; Maldonado, H.
Filiación:Lab. Fisiol. Comportamiento Anim., Fac. de Ciencias Exactas y Naturales, Pabellon II (1428), Buenos Aires, Argentina
Palabras clave:crab; cyproheptadine; sensitization; serotonin; cyproheptadine; serotonin; serotonin antagonist; serotonin receptor; animal experiment; article; controlled study; crab; drug antagonism; escape behavior; male; nonhuman; priority journal; sensitization; Animalia; Aplysia; Chasmagnathus; Chasmagnathus granulata; Decapoda (Crustacea)
Año:1996
Volumen:53
Número:2
Página de inicio:441
Página de fin:448
DOI: http://dx.doi.org/10.1016/0091-3057(95)02015-2
Título revista:Pharmacology Biochemistry and Behavior
Título revista abreviado:PHARMACOL. BIOCHEM. BEHAV.
ISSN:00913057
CODEN:PBBHA
CAS:cyproheptadine, 129-03-3, 969-33-5; serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v53_n2_p441_Aggio

Referencias:

  • Aggio, J., Maldonado, H., Unpublished data; Appleton, T., Wilkens, J.L., Habituation, sensitization and the effect of serotonin on the eyestalk withdrawal reflex of Cancer magister (1990) Comp. Biochem. Physiol., 97 A, pp. 159-163
  • Bailey, C.H., Chen, M., Morphological basis of long-term habituation and sensitization in Aplysia (1983) Science, 220, pp. 91-93
  • Bradley, P.B., Engel, G., Feniuk, W., Fozard, J.R., Humphrey, P.P.A., Middlemiss, D.N., Mylecharane, E.J., Saxena, P.R., Proposals for the classification and nomenclature of functional receptors for 5-Hydroxytryptamine (1986) Neuropharmacology, 25, pp. 563-576
  • Brunner, D., Maldonado, H., Habituation in the crab Chasmagnathus granulatus: Effect of morphine and naloxone (1988) J. Comp. Physiol. [A], 162, pp. 687-694
  • Byrne, J., Baxter, D., Buonomano, D., Cleary, L., Eskin, A., Goldsmith, J., McClendon, E., Scholz, K., Neural and molecular bases of nonassociative and associative learning in Aplysia (1991) Activity-driven C.N.S. Changes in Learning and Development, 627, pp. 124-149. , Wolpan, J.; Schmidt, J.; Vaughan, T., eds. New York: Annals of the New York Academy of Sciences
  • Clark, G.A., Kandel, E.R.K., Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 11411-11415
  • El Manira, A., Clarac, F., Presynaptic inhibition is mediated by histamine and GABA in the crustacean escape reaction (1994) J. Neurophysiol., 71 (3), pp. 1088-1095
  • Emptage, N., Carew, T.J., Long-term facilitation in the absence of short-term facilitation in Aplysia neurons (1993) Science, 262, pp. 253-256
  • Erber, J., Kloppenburg, P., Schleider, A., Neuromodulation by serotonin and octopamine in the honeybee: Behaviour, neuroanatomy and electrophysiology (1993) Experientia, 49, pp. 1073-1083
  • Erber, J., Sandeman, D.C., The modulation of the optokinetic response of the crab Leptograsus variegatus (1989) J. Neurobiol., 20, pp. 667-680
  • Fredericq, L., Sur l'autotomie ou mutilation par voie reflexe comme moyen de defense chez les animaux (1883) Arch. Zool. Exp. Gen., 1, pp. 413-426
  • Glanzman, D.L., Krasne, F.B., Serotonin and octopamine have opposite modulatory effects on the crayfish's lateral giant escape reaction (1983) J. Neurosci., 3, pp. 2263-2269
  • Glanzman, D.L., Krasne, F.B., 5,7-Dihyroxytryptamine lesions of crayfish serotonin-containing neurons: Effect on the lateral giant escape reaction (1986) J. Neurosci., 6, pp. 1560-1569
  • Godoy, A.M., Maldonado, H., Modulation of the escape response by D(ala-2)Met-enkephalin in the crab Chasmagnathus (1995) Pharmacol. Biochem. Physiol., 50 (3), pp. 445-459
  • Goldstein, R.S., Camhi, J.M., Different effects of the biogenic amines dopamine, serotonin and octopamine on the thoracic and abdominal portions of the escape circuit in the cockroach (1991) J. Comp. Pysiol. [A], 168, pp. 103-112
  • Handley, S.L., McBane, J.W., Serotonin mechanisms in animal models of anxiety (1993) Braz. J. Med. Biol. Res., 26, pp. 1-13
  • Handley, S.L., McBlane, J.W., Critchley, M.A.E., Njung'e, K., Multiple serotonin mechanisms in animal models of anxiety: Environmental, emotional and cognitive factors (1993) Behav. Brain Res., 58, pp. 203-210
  • Harris-Warrick, R., Kravitz, E., Cellular mechanisms for modulation of posture by octopamine and serotonin in the lobster (1984) J. Neurosci., 5, pp. 1976-1993
  • Hoeger, U., Florey, E., Catecholamine degradation in the hemolymph of the chinese crab, Eriocher Sinensis (1989) Comp. Biochem. Physiol. [C], 92, pp. 323-327
  • Holliday, M., Hirsch, J., Excitatory conditioning of individual Drosophila melanogaster (1986) J. Exp. Psychol. Anim. Behav. Process, 12 (2), pp. 131-142
  • Kandel, E.R., Schwartz, J.H., Molecular biology of learning: Modulation of transmitter release (1982) Science, 218, pp. 433-442
  • Klein, J.L., Galant, S.P., A comparison of the antipruritic effect of hydroxizine and cyproheptadine in children with atopic dermatitis (1980) Ann. Allergy, 44, pp. 142-145
  • Kravitz, E.A., Hormonal control of behaviour: Amines and the biasing of behavioural output in lobsters (1988) Science, 241, pp. 1775-1781
  • Livingstone, M., Harris-Warrick, R.M., Kravitz, E.A., Serotonin and octopamine produce opposite postures in lobsters (1980) Nature, 208, pp. 76-79
  • Lozada, M., (1994) Habituación a Largo Términe y Especificidad del Estimulo en el Cangrejo Chasmagnathus granulatus, , Doctoral Thesis, University of Buenos Aires
  • Lüschen, W., Willig, A., Jaros, P.P., The role of biogenic amines in the control of blood glucose level in the decapod crustacean, Carcinus maenas L. (1993) Comp. Biochem. Physiol. [C], 105, pp. 291-296
  • Maldonado, H., Romano, A., Lozada, M., Opioid action on response level to a danger stimulus in the crab (Chasmagnathus granulathus) (1989) Behav. Neurol., 103 (5), pp. 1139-1143
  • Mattson, M.P., Spaziani, E., Regulation of the stress-responsive X-organ-Y-organ axis by 5-Hydroxytryptamine in the crab, Cancer antennarius (1986) Gen. Comp. Endocrinol., 62, pp. 419-427
  • McPhee, M.J., Wilkens, J.L., Serotonin, but not dopamine or octopamine, modifies locomotor and phototactic behaviour of the crab, Carcinus maenas (1989) Can. J. Zool., 67, pp. 391-393
  • Médioni, J., Cadieu, N., Vaysse, G., Sélection dicergente pour la rapidité d'acquisition d'un conditionnement chez la Drosophile (Drosophila melanogaster) (1978) C. R. Seances Soc. Biol., 174, pp. 961-967
  • Mercer, A.R., Emptage, N.J., Carew, T.J., Pharmacological dissociation of modulatory effects of serotonin in Aplysia sensory neurons (1991) Science, 254, pp. 1811-1813
  • Pedreira, M.E., Dimant, B., Maldonado, H., Actinomycin-D Inhibits Context Memory and Long-term Habituation in the Crab Chasmagnathus, , Submitted
  • Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allué, L.A., Maldonado, H., Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus (1995) Behav. Neur. Biol., 52 (1)
  • Pereyra, P., De La Iglesia, H., Maldonado, H., Training to testing intervals different from 24 hours impair habituation in the crab Chasmagnathus (1995) Physiol. Behav., 50
  • Peroutka, S.J., Lebovitz, R.M., Snyder, S.H., Two distinct central serotonin receptors with different physiological functions (1981) Science, 212, pp. 827-829
  • Rakitin, A., Tomsic, D., Maldonado, H., Habituation and sensitization to an electrical shock in the crab Chasmagnathus. Effect of background illumination (1991) Physiol. Behav., 50, pp. 477-487
  • Romano, A., Lozada, M., Maldonado, H., Effect of naloxone pretreatment on habituation in the crab Chasmagnathus granulatus (1990) Behav. Neural Biol., 53, pp. 113-122
  • Romano, A., Lozada, M., Maldonado, H., Nonhabituation processes affect stimulus specificity of response habituation of the crab Chasmagnathus granulatus (1991) Behav. Neurosci., 105, pp. 542-552
  • Schuman, E.M., Clark, G.A., Synaptic facilitation at connections of Hermissenda type B photoreceptors (1994) J. Neurosci., 14, pp. 1613-1622
  • Tomsic, D., Dimant, B., Maldonado, H., Age-related deficit of long-term memory in an invertebrate (1995) J. Comp. Physiol. A., 176
  • Tomsic, D., Maldonado, H., Rakitin, A., Morphine and GABA: Effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus (1991) Brain Res. Bull., 26, pp. 699-706
  • Tomsic, D., Massoni, V., Maldonado, H., Habituation to a danger stimulus in two semiterrestrial crabs: Ontogenic, ecological and opioid modulation correlates (1993) J. Comp. Physiol. [A], 173, pp. 621-633
  • Valeggia, C., Fernàndez-Duque, E., Maldonado, H., Danger stimulus-induced analgesia in the crab Chasmagnathus granulatus (1989) Brain Res., 481, pp. 304-308
  • Wiersma, C.A.G., Fiore, L., Factors regulating the discharge frecuency in optomotor fibers of Carcinus maenas (1971) J. Exp. Biol., 54, pp. 497-505
  • Wilkens, J.L., Mercier, A.J., Evans, J., Cardiac and ventilatory responses to stress and to neurohormonal modulators by the shore crab, Carcinus maenas (1985) Comp. Biochem. Physiol. [C], 82, pp. 337-343
  • Willard, A.L., Effect of serotonin on the generation of the motor program for swimming by the medicinal leech (1981) J. Neurosci., 1, pp. 936-944
  • Wright, H., Visual display in brachiuran crabs: Field and laboratory studies (1967) Am. Zool., 8, pp. 655-665

Citas:

---------- APA ----------
Aggio, J., Rakitín, A. & Maldonado, H. (1996) . Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus. Pharmacology Biochemistry and Behavior, 53(2), 441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2
---------- CHICAGO ----------
Aggio, J., Rakitín, A., Maldonado, H. "Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus" . Pharmacology Biochemistry and Behavior 53, no. 2 (1996) : 441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2
---------- MLA ----------
Aggio, J., Rakitín, A., Maldonado, H. "Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus" . Pharmacology Biochemistry and Behavior, vol. 53, no. 2, 1996, pp. 441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2
---------- VANCOUVER ----------
Aggio, J., Rakitín, A., Maldonado, H. Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus. PHARMACOL. BIOCHEM. BEHAV. 1996;53(2):441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2