Abstract:
On sudden presentation of a passing shadow a visual danger stimulus), the crab Chasmagnathus granulatus responds with a running reaction that we term an escape response (ER). A single administration of 5-HT in a dose range between 0.005 and 0.1 μg/g enhances the ER at 30 min, and a dose of 10-15 μg/g has a similar effect for at least 24 h. The classical 5-HT antagonist cyproheptadine (CYP) given within a dose range 0.01-2.0 μg/g has no effect on ER at 30 min, but 0.5 μg/g blocks the 5-HT-induced short-term sensitization. An enhancing effect of CYP on the ER is shown at 24 h with 1.0-2.0 μg/g doses. An explanation of this results in terms of a model similar to that proposed for Aplysia, that is two sensitizing processes linked in parallel and mediated by two different types of 5-HT receptors is discussed. Results indicate that the sensitizing effect of 5-HT is confined to high responders, thus suggesting that crabs of a same population have different degrees of sensitivity to the drug according to their different degrees of reactivity to the visual danger stimulus.
Registro:
Documento: |
Artículo
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Título: | Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus |
Autor: | Aggio, J.; Rakitín, A.; Maldonado, H. |
Filiación: | Lab. Fisiol. Comportamiento Anim., Fac. de Ciencias Exactas y Naturales, Pabellon II (1428), Buenos Aires, Argentina
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Palabras clave: | crab; cyproheptadine; sensitization; serotonin; cyproheptadine; serotonin; serotonin antagonist; serotonin receptor; animal experiment; article; controlled study; crab; drug antagonism; escape behavior; male; nonhuman; priority journal; sensitization; Animalia; Aplysia; Chasmagnathus; Chasmagnathus granulata; Decapoda (Crustacea) |
Año: | 1996
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Volumen: | 53
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Número: | 2
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Página de inicio: | 441
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Página de fin: | 448
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DOI: |
http://dx.doi.org/10.1016/0091-3057(95)02015-2 |
Título revista: | Pharmacology Biochemistry and Behavior
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Título revista abreviado: | PHARMACOL. BIOCHEM. BEHAV.
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ISSN: | 00913057
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CODEN: | PBBHA
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CAS: | cyproheptadine, 129-03-3, 969-33-5; serotonin, 50-67-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v53_n2_p441_Aggio |
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Citas:
---------- APA ----------
Aggio, J., Rakitín, A. & Maldonado, H.
(1996)
. Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus. Pharmacology Biochemistry and Behavior, 53(2), 441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2---------- CHICAGO ----------
Aggio, J., Rakitín, A., Maldonado, H.
"Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus"
. Pharmacology Biochemistry and Behavior 53, no. 2
(1996) : 441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2---------- MLA ----------
Aggio, J., Rakitín, A., Maldonado, H.
"Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus"
. Pharmacology Biochemistry and Behavior, vol. 53, no. 2, 1996, pp. 441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2---------- VANCOUVER ----------
Aggio, J., Rakitín, A., Maldonado, H. Serotonin-induced short- and long-term sensitization in the crab Chasmagnathus. PHARMACOL. BIOCHEM. BEHAV. 1996;53(2):441-448.
http://dx.doi.org/10.1016/0091-3057(95)02015-2