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Abstract:

The synthetic opioid analog [d-Ala2]Met-enkephalin (DAME) significantly reduces the escape response to a danger stimulus in the crab Chasmagnathus granulatus when administered within the dose range 0.01-1.0 μg/g. There is no reduction with lower or higher doses, thus suggesting a U-shaped dose-response curve. A 0.1-μg/g dose of naloxone has no effect per se on the response, but when it is administered together with DAME, it completely blocks the decrementai effect of this drug and an escape response generally higher than that of control is observed. An explanation for these results in terms of a possible dual action of DAME is offered. In addition, we present evidence for different degrees of opiate sensitivity among crabs of the same population in relation to their different degrees of reactivity to the visual danger stimulus. © 1995.

Registro:

Documento: Artículo
Título:Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus
Autor:Godoy, A.M.; Maldonado, H.
Filiación:Laboratorio de Fisiología del Comportamiento Animal, Facultad de Ciencias Exactas y Naturales, Departamento de Biología, Ciudad Universitaria, Pabellon II (1428), Buenos Aires, Argentina
Palabras clave:Crab; Habituation; Met-enkephalin; Opioid; metenkephalin[2 dextro alanine]; naloxone; opiate; animal experiment; article; controlled study; crab; dose response; drug antagonism; escape behavior; habituation; male; nonhuman; priority journal; Animal; Brachyura; Enkephalin, Methionine; Escape Reaction; Male; Pilot Projects
Año:1995
Volumen:50
Número:3
Página de inicio:445
Página de fin:451
DOI: http://dx.doi.org/10.1016/0091-3057(94)00295-T
Título revista:Pharmacology, Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
ISSN:00913057
CODEN:PBBHA
CAS:metenkephalin[2 dextro alanine], 61370-87-4; naloxone, 357-08-4, 465-65-6; opiate, 53663-61-9, 8002-76-4, 8008-60-4; Enkephalin, Methionine, 58569-55-4; enkephalinamide-Met, Ala(2)-, 61090-95-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v50_n3_p445_Godoy

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Citas:

---------- APA ----------
Godoy, A.M. & Maldonado, H. (1995) . Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. Pharmacology, Biochemistry and Behavior, 50(3), 445-451.
http://dx.doi.org/10.1016/0091-3057(94)00295-T
---------- CHICAGO ----------
Godoy, A.M., Maldonado, H. "Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus" . Pharmacology, Biochemistry and Behavior 50, no. 3 (1995) : 445-451.
http://dx.doi.org/10.1016/0091-3057(94)00295-T
---------- MLA ----------
Godoy, A.M., Maldonado, H. "Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus" . Pharmacology, Biochemistry and Behavior, vol. 50, no. 3, 1995, pp. 445-451.
http://dx.doi.org/10.1016/0091-3057(94)00295-T
---------- VANCOUVER ----------
Godoy, A.M., Maldonado, H. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. Pharmacol. Biochem. Behav. 1995;50(3):445-451.
http://dx.doi.org/10.1016/0091-3057(94)00295-T