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Brusés, J.L.; Berninsone, P.M.; Ojea, S.I.; Azcurra, J.M. "The circling training rat model as a behavioral teratology test" (1991) Pharmacology, Biochemistry and Behavior. 38(4):739-745
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Abstract:

The properties of circling training (CT) for detecting behavioral teratologic drug-induced effects was evaluated by prenatal administration of two behavioral teratogenic drugs: vitamin A (80,000 IU/kg/day) and haloperidol (2.5 mg/kg/day). The circling training was started at 30 days of age and performed for 8 days in an automated apparatus. Statistically significant differences between drug-treated and control animals regarding the measured response (turns per minute) were found. Two components may affect the response measured by the CT: associative learning and motor performance. The incidence of these components was discriminated with behavioral and mathematical approaches. In the experimental conditions used the most affected parameter was motor performance. The results indicate that CT can be used as an instrumental conditioning test where the quantifiable endpoint is the on-going motor performance. Further applications of the CT for neurochemical evaluation of drug induced effects are also discussed. © 1991.

Registro:

Documento: Artículo
Título:The circling training rat model as a behavioral teratology test
Autor:Brusés, J.L.; Berninsone, P.M.; Ojea, S.I.; Azcurra, J.M.
Filiación:Laboratorio de Biologia Celular, Depto. de Ciencias Biológicas Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:Behavioral teratology; Caudate nuclei; Circling training; Haloperidol; Operant conditioning; Vitamin A; haloperidol; retinol; adolescent; animal experiment; animal model; article; behavior teratology; circling behavior; controlled study; female; instrumental conditioning; intraperitoneal drug administration; male; mathematical analysis; maze test; nonhuman; prenatal drug exposure; priority journal; rat; training; Animal; Behavior, Animal; Caudate Nucleus; Conditioning, Operant; Female; Haloperidol; Maternal-Fetal Exchange; Pregnancy; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Teratogens; Vitamin A
Año:1991
Volumen:38
Número:4
Página de inicio:739
Página de fin:745
DOI: http://dx.doi.org/10.1016/0091-3057(91)90235-T
Título revista:Pharmacology, Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
ISSN:00913057
CODEN:PBBHA
CAS:Haloperidol, 52-86-8; Teratogens; Vitamin A, 11103-57-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v38_n4_p739_Bruses

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Citas:

---------- APA ----------
Brusés, J.L., Berninsone, P.M., Ojea, S.I. & Azcurra, J.M. (1991) . The circling training rat model as a behavioral teratology test. Pharmacology, Biochemistry and Behavior, 38(4), 739-745.
http://dx.doi.org/10.1016/0091-3057(91)90235-T
---------- CHICAGO ----------
Brusés, J.L., Berninsone, P.M., Ojea, S.I., Azcurra, J.M. "The circling training rat model as a behavioral teratology test" . Pharmacology, Biochemistry and Behavior 38, no. 4 (1991) : 739-745.
http://dx.doi.org/10.1016/0091-3057(91)90235-T
---------- MLA ----------
Brusés, J.L., Berninsone, P.M., Ojea, S.I., Azcurra, J.M. "The circling training rat model as a behavioral teratology test" . Pharmacology, Biochemistry and Behavior, vol. 38, no. 4, 1991, pp. 739-745.
http://dx.doi.org/10.1016/0091-3057(91)90235-T
---------- VANCOUVER ----------
Brusés, J.L., Berninsone, P.M., Ojea, S.I., Azcurra, J.M. The circling training rat model as a behavioral teratology test. Pharmacol. Biochem. Behav. 1991;38(4):739-745.
http://dx.doi.org/10.1016/0091-3057(91)90235-T