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Abstract:

Morphine is believed to inhibit the crab's escape response to a danger stimulus due to central drug action. To test alternative explanations of such an effect in terms of afferent and/or efferent impairment, experiments were conducted using the crab's optokinetic response as indicator. Doses of morphine with maximal detrimental effect on the escape response (75-100 μg/g) showed no effect on the optokinetic response, both by measuring the crab's eyestalk displacement and by recording its body rotation, supporting the hypothesis of a morphine central action on the danger-induced escape re sponse. As regards the effet on habituation, a 75 μ morphine/g injection administered 30 min before the first trial produced a parallel shift of the short-term (within-session) habituation curve, suggesting a modulatory central drug action that would mimic a putative endogeneous opioid action. A 100 morphine μg/g dose injected 30 min before training sharply reduced reactivity during training and impaired the acquisition of long-term (between-session) habituation. It may be speculated that the decrease in the danger meaning of the stimulus due to morphine explains both effects in terms of a stimulation impairment during training. © 1990.

Registro:

Documento: Artículo
Título:Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus
Autor:Tomsic, D.; Maldonado, H.
Filiación:Laboratorio de Fisiologia del Comportamiento Animal, Facultad de Ciencias Exactas y Naturales UBA, Avda Indalecio Chenaut 1910, 1426 Buenos Aires, Argentina
Palabras clave:Danger stimulus Crustacea; Long-term habituation; Morphine; Opiates; Optokinetic response; Short-term habituation; morphine; animal experiment; article; drug tolerance; invertebrate; nonhuman; optokinetic stimulation; priority journal; Animal; Brachyura; Habituation (Psychophysiology); Male; Morphine; Motor Activity; Support, Non-U.S. Gov't; Animalia; Chasmagnathus; Crustacea; Decapoda (Crustacea); Invertebrata
Año:1990
Volumen:36
Número:4
Página de inicio:787
Página de fin:793
DOI: http://dx.doi.org/10.1016/0091-3057(90)90078-V
Título revista:Pharmacology, Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
ISSN:00913057
CODEN:PBBHA
CAS:Morphine, 57-27-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v36_n4_p787_Tomsic

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Citas:

---------- APA ----------
Tomsic, D. & Maldonado, H. (1990) . Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus. Pharmacology, Biochemistry and Behavior, 36(4), 787-793.
http://dx.doi.org/10.1016/0091-3057(90)90078-V
---------- CHICAGO ----------
Tomsic, D., Maldonado, H. "Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus" . Pharmacology, Biochemistry and Behavior 36, no. 4 (1990) : 787-793.
http://dx.doi.org/10.1016/0091-3057(90)90078-V
---------- MLA ----------
Tomsic, D., Maldonado, H. "Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus" . Pharmacology, Biochemistry and Behavior, vol. 36, no. 4, 1990, pp. 787-793.
http://dx.doi.org/10.1016/0091-3057(90)90078-V
---------- VANCOUVER ----------
Tomsic, D., Maldonado, H. Central effect of morphine pretreatment on short- and long-term habituation to a danger stimulus in the crab Chasmagnathus. Pharmacol. Biochem. Behav. 1990;36(4):787-793.
http://dx.doi.org/10.1016/0091-3057(90)90078-V