Caceres, L.G.; Cid, M.P.; Uran, S.L.; Zorrilla Zubilete, M.A.; Salvatierra, N.A.; Guelman, L.R. "Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety" (2013) Pharmacology Biochemistry and Behavior. 111:37-43
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It is widely known that ionizing radiation is a physical agent broadly used to kill tumor cells during human cancer therapy. Unfortunately, adjacent normal tissues can concurrently undergo undesirable cell injury. Previous data of our laboratory demonstrated that exposure of developing rats to ionizing radiations induced a variety of behavioral differences respect to controls, including changes in associative memory and in anxiety state. However, there is a lack of data concerning modifications in different related pharmacological intermediaries. Therefore, the aim of the present study was to investigate whether the behavioral differences observed in young animals irradiated at birth might be underlain by early changes in PKCß1 levels which, in turn, could lead to changes in hippocampal GABAergic neurotransmission. Male Wistar rats were irradiated with 5 Gy of X rays between 24 and 48 h after birth. Different pharmacological markers related to the affected behavioral tasks were assessed in control and irradiated hippocampus at 15 and 30 days, namely GABAA receptor, GAD65-67, ROS and PKCß1. Results showed that all measured parameters were increased in the hippocampus of 30-days-old irradiated animals. In contrast, in the hippocampus of 15-days-old irradiated animals only the levels of PKCß1 were decreased. These data suggest that PKCß1 might constitute a primary target for neonatal radiation damage on the hippocampus. Therefore, it could be hypothesized that an initial decrease in the levels of this protein can trigger a subsequent compensatory increase that, in turn, could be responsible for the plethora of biochemical changes that might underlie the previously observed behavioral alterations. © 2013 Elsevier Inc.


Documento: Artículo
Título:Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety
Autor:Caceres, L.G.; Cid, M.P.; Uran, S.L.; Zorrilla Zubilete, M.A.; Salvatierra, N.A.; Guelman, L.R.
Filiación:1a Cátedra de Farmacología, Facultad de Medicina, UBA-CEFyBO-CONICET, Paraguay 2155, piso 15, (1121) Buenos Aires, Argentina
Cátedra de Química Orgánica Biológica, Facultad de Ciencias Exactas Físicas y Naturales, UNC, Vélez Sarsfield 299, Córdoba, Argentina
Idioma: Inglés
Palabras clave:GABA; GAD; Hippocampus; Ionizing radiations; PKCß1; ROS; 4 aminobutyric acid A receptor; glutamate decarboxylase 65; glutamate decarboxylase 67; protein kinase C beta; reactive oxygen metabolite; animal experiment; animal model; anxiety; article; associative memory; controlled study; female; hippocampus; ionizing radiation; juvenile animal; male; nonhuman; priority journal; radiation injury; rat; Animalia; Rattus; Rattus norvegicus
Página de inicio:37
Página de fin:43
Título revista:Pharmacology Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.


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---------- APA ----------
Caceres, L.G., Cid, M.P., Uran, S.L., Zorrilla Zubilete, M.A., Salvatierra, N.A. & Guelman, L.R. (2013) . Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety. Pharmacology Biochemistry and Behavior, 111, 37-43.
---------- CHICAGO ----------
Caceres, L.G., Cid, M.P., Uran, S.L., Zorrilla Zubilete, M.A., Salvatierra, N.A., Guelman, L.R. "Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety" . Pharmacology Biochemistry and Behavior 111 (2013) : 37-43.
---------- MLA ----------
Caceres, L.G., Cid, M.P., Uran, S.L., Zorrilla Zubilete, M.A., Salvatierra, N.A., Guelman, L.R. "Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety" . Pharmacology Biochemistry and Behavior, vol. 111, 2013, pp. 37-43.
---------- VANCOUVER ----------
Caceres, L.G., Cid, M.P., Uran, S.L., Zorrilla Zubilete, M.A., Salvatierra, N.A., Guelman, L.R. Pharmacological alterations that could underlie radiation-induced changes in associative memory and anxiety. Pharmacol. Biochem. Behav. 2013;111:37-43.