Artículo

De Nicola, A.F.; Labombarda, F.; Deniselle, M.C.G.; Gonzalez, S.L.; Garay, L.; Meyer, M.; Gargiulo, G.; Guennoun, R.; Schumacher, M. "Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration" (2009) Frontiers in Neuroendocrinology. 30(2):173-187
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Abstract:

Studies on the neuroprotective and promyelinating effects of progesterone in the nervous system are of great interest due to their potential clinical connotations. In peripheral neuropathies, progesterone and reduced derivatives promote remyelination, axonal regeneration and the recovery of function. In traumatic brain injury (TBI), progesterone has the ability to reduce edema and inflammatory cytokines, prevent neuronal loss and improve functional outcomes. Clinical trials have shown that short-and long-term progesterone treatment induces a significant improvement in the level of disability among patients with brain injury. In experimental spinal cord injury (SCI), molecular markers of functional motoneurons become impaired, including brain-derived neurotrophic factor (BDNF) mRNA, Na,K-ATPase mRNA, microtubule-associated protein 2 and choline acetyltransferase (ChAT). SCI also produces motoneuron chromatolysis. Progesterone treatment restores the expression of these molecules while chromatolysis subsided. SCI also causes oligodendrocyte loss and demyelination. In this case, a short progesterone treatment enhances proliferation and differentiation of oligodendrocyte progenitors into mature myelin-producing cells, whereas prolonged treatment increases a transcription factor (Olig1) needed to repair injury-induced demyelination. Progesterone neuroprotection has also been shown in motoneuron neurodegeneration. In Wobbler mice spinal cord, progesterone reverses the impaired expression of BDNF, ChAT and Na,K-ATPase, prevents vacuolar motoneuron degeneration and the development of mitochondrial abnormalities, while functionally increases muscle strength and the survival of Wobbler mice. Multiple mechanisms contribute to these progesterone effects, and the role played by classical nuclear receptors, extra nuclear receptors, membrane receptors, and the reduced metabolites of progesterone in neuroprotection and myelin formation remain an exciting field worth of exploration. © 2009 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration
Autor:De Nicola, A.F.; Labombarda, F.; Deniselle, M.C.G.; Gonzalez, S.L.; Garay, L.; Meyer, M.; Gargiulo, G.; Guennoun, R.; Schumacher, M.
Filiación:Laboratory of Neuroendocrine Biochemistry, Instituto de Biologia y Medicina Experimental-CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
Dept. of Human Biochemistry, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina
UMR788 Inserm and University Paris-Sud 11, Kremlin-Bicêtre, France
Palabras clave:Brain injury; Myelination; Neuroactive steroid; Neurodegeneration; Oligodendrocytes; Progesterone; Spinal cord; Wobbler mouse; 20alpha dihydroprogesterone; 3alpha hydroxy 5alpha pregnan 20 one; adenosine triphosphatase (potassium sodium); brain derived neurotrophic factor; cell nucleus receptor; choline acetyltransferase; medroxyprogesterone acetate; membrane receptor; messenger RNA; microtubule associated protein 2; myelin; placebo; progesterone; progesterone receptor; brain edema; brain injury; cell loss; central nervous system disease; clinical trial; demyelination; diabetic neuropathy; disability; disorders of mitochondrial functions; dose response; drug efficacy; drug mechanism; drug megadose; drug safety; gene expression regulation; hormone action; human; immunohistochemistry; low drug dose; motoneuron; mouse strain; muscle strength; nerve degeneration; nerve fiber regeneration; nerve function; nerve injury; nervous system injury; neuroanatomy; neurochemistry; neuroprotection; nonhuman; oligodendroglia; optimal drug dose; peripheral nerve injury; peripheral neuropathy; priority journal; remyelinization; review; sex difference; spinal cord injury; traumatic brain injury; treatment duration; Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Clinical Trials as Topic; Disease Models, Animal; Humans; Mice; Mice, Neurologic Mutants; Motor Neurons; Myelin Sheath; Nerve Degeneration; Neuroprotective Agents; Oligodendroglia; Receptors, Progesterone; Sex Factors; Spinal Cord Injuries; Trauma, Nervous System
Año:2009
Volumen:30
Número:2
Página de inicio:173
Página de fin:187
DOI: http://dx.doi.org/10.1016/j.yfrne.2009.03.001
Título revista:Frontiers in Neuroendocrinology
Título revista abreviado:Front. Neuroendocrinol.
ISSN:00913022
CODEN:FNEDA
CAS:20alpha dihydroprogesterone, 145-14-2; 3alpha hydroxy 5alpha pregnan 20 one, 516-54-1; brain derived neurotrophic factor, 218441-99-7; choline acetyltransferase, 9012-78-6; medroxyprogesterone acetate, 71-58-9; progesterone, 57-83-0; Brain-Derived Neurotrophic Factor; Neuroprotective Agents; Receptors, Progesterone
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913022_v30_n2_p173_DeNicola

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Citas:

---------- APA ----------
De Nicola, A.F., Labombarda, F., Deniselle, M.C.G., Gonzalez, S.L., Garay, L., Meyer, M., Gargiulo, G.,..., Schumacher, M. (2009) . Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Frontiers in Neuroendocrinology, 30(2), 173-187.
http://dx.doi.org/10.1016/j.yfrne.2009.03.001
---------- CHICAGO ----------
De Nicola, A.F., Labombarda, F., Deniselle, M.C.G., Gonzalez, S.L., Garay, L., Meyer, M., et al. "Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration" . Frontiers in Neuroendocrinology 30, no. 2 (2009) : 173-187.
http://dx.doi.org/10.1016/j.yfrne.2009.03.001
---------- MLA ----------
De Nicola, A.F., Labombarda, F., Deniselle, M.C.G., Gonzalez, S.L., Garay, L., Meyer, M., et al. "Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration" . Frontiers in Neuroendocrinology, vol. 30, no. 2, 2009, pp. 173-187.
http://dx.doi.org/10.1016/j.yfrne.2009.03.001
---------- VANCOUVER ----------
De Nicola, A.F., Labombarda, F., Deniselle, M.C.G., Gonzalez, S.L., Garay, L., Meyer, M., et al. Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Front. Neuroendocrinol. 2009;30(2):173-187.
http://dx.doi.org/10.1016/j.yfrne.2009.03.001