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Chazenbalk, G.D.; Valsecchi, R.M.; Krwaiec, L.; Burton, G.; Juvenal, G.J.; Monteagudo, E.; Chester, H.A.; Pisarev, M.A. "Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism" (1988) Prostaglandins. 36(2):163-172
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Abstract:

Thyroid autoregulation has been linked to an organified iodocompound. Since several iodolipids are produced by the gland their possible role in thyroid autoregulation was examined. The following pure synthetic compounds were prepared: 1) 14-iodo-15-hydroxy-5,8,11-eicosatrienoic acid (I-OH-A); 2) its omega lactone (IL-ω);3)5-hydroxy-6-iodo-8,11,14-eicosatrienoic acid delta lactone (IL-δ). Their action on iodine metabolism was studied. Iodine uptake was measured in calf thyroid slices. At 10-4M I-OH-A caused a 64% decrease in the T/M ratio while IL-ω inhibited it by 36% and IL-δ was without effect. At 10−5M the inhibition was 44% for I-OH-A and 19% for IL-ω, while T3 was without action. A possible isotopic dilution effect was excluded, and no change in iodine efflux was observed. The inhibition by I-OH-A of iodine uptake was observed after only 15 min preincubation. This compound alse decreased 125I accumulation in rats. In calf thyroid slice, I-OH-A at 10−4M, inhibited PB125I formation by 80%, IL-ω 62% and IL-ω by 37% and arachidonic acid were without action. I-OH-A also caused a dose-dependent inhibition of TSH-stimulated iodide organification. The present results demonstrate, for the first time, that iodinated derivatives of arachidonic acid inhibition thyroid function and mimic the effect of iodine on thyroid autoregulation. © 1988, All rights reserved.

Registro:

Documento: Artículo
Título:Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism
Autor:Chazenbalk, G.D.; Valsecchi, R.M.; Krwaiec, L.; Burton, G.; Juvenal, G.J.; Monteagudo, E.; Chester, H.A.; Pisarev, M.A.
Filiación:Division Bioquimica Nuclear, Gerencia de Radioisótopos, Comisión Nacional de Energía, Atómica; Depto. Química Orgánica, Facultad de Ciencias Exastas y Naturales, Buenos Aires, Argentina
Palabras clave:15 hydroxy 14 iodo 5,8,11 icosatrienoic acid; 15 hydroxy 14 iodo 5,8,11 icosatrienoic acid; arachidonic acid derivative; liothyronine; radioisotope; thyroid iodine; unclassified drug; animal cell; animal experiment; article; autoregulation; cattle; controlled study; intraperitoneal drug administration; newborn; nonhuman; rat; thyroid gland; Animalia; Bos taurus
Año:1988
Volumen:36
Número:2
Página de inicio:163
Página de fin:172
DOI: http://dx.doi.org/10.1016/0090-6980(88)90303-6
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CAS:liothyronine, 6138-47-2, 6893-02-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v36_n2_p163_Chazenbalk

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Citas:

---------- APA ----------
Chazenbalk, G.D., Valsecchi, R.M., Krwaiec, L., Burton, G., Juvenal, G.J., Monteagudo, E., Chester, H.A.,..., Pisarev, M.A. (1988) . Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism. Prostaglandins, 36(2), 163-172.
http://dx.doi.org/10.1016/0090-6980(88)90303-6
---------- CHICAGO ----------
Chazenbalk, G.D., Valsecchi, R.M., Krwaiec, L., Burton, G., Juvenal, G.J., Monteagudo, E., et al. "Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism" . Prostaglandins 36, no. 2 (1988) : 163-172.
http://dx.doi.org/10.1016/0090-6980(88)90303-6
---------- MLA ----------
Chazenbalk, G.D., Valsecchi, R.M., Krwaiec, L., Burton, G., Juvenal, G.J., Monteagudo, E., et al. "Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism" . Prostaglandins, vol. 36, no. 2, 1988, pp. 163-172.
http://dx.doi.org/10.1016/0090-6980(88)90303-6
---------- VANCOUVER ----------
Chazenbalk, G.D., Valsecchi, R.M., Krwaiec, L., Burton, G., Juvenal, G.J., Monteagudo, E., et al. Thyroid autoregulation. Inhibitory effects of iodinated derivatives of arachidonic acid on iodine metabolism. Prostaglandins. 1988;36(2):163-172.
http://dx.doi.org/10.1016/0090-6980(88)90303-6