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Abstract:

Methoxamine enhanced contractions of mouse vasa deferentia through alpha adrenoceptor stimulation. Additionally, the generation of PGF-like material by the tissue was increased by methoxamine, whereas that of PGE-like material was decreased. The effects of methoxamine on prostaglandin output (stimulation and depression) were antagonized by yohimbine and phenoxybenzamine. Moreover, the stimulating influence of methoxamine on the contractile activity of the preparations was attenuated by the prostaglandin synthesis inhibitors indomethacin and acetylsalicylic acid. The results suggest that methoxamine is able to modify prostaglandin synthesis and output in mouse vasa deferentia, probably through an alpha adrenergic mediated mechanism coupled to the prostaglandin synthesizing system. The fact that indomethacin and acetylsalicylic acid blocked alpha stimulatory responses to methoxamine, suggest a modulatory role for endogenous prostaglandins. Since methoxamine increased PGF levels, this prostaglandin might potentiate the contractile influence of methoxamine. © 1983.

Registro:

Documento: Artículo
Título:Alpha adrenergic stimulation modified prostaglandins release in vas deferens
Autor:Borda, E.S.; Peredo, H.; Gimeno, M.F.
Filiación:Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Re, 1414 Buenos Aires, Argentina
Palabras clave:acetylsalicylic acid; alpha adrenergic receptor; indometacin; methoxamine; phenoxybenzamine; prostaglandin; prostaglandin e2; prostaglandin f2 alpha trometamol; yohimbine; animal cell; autonomic nervous system; drug efficacy; male genital system; mouse; nonhuman; sympathetic nerve; vas deferens; Animal; Aspirin; Cyclooxygenase Inhibitors; Indomethacin; Male; Methoxamine; Mice; Muscle Contraction; Phenoxybenzamine; Prostaglandins E; Prostaglandins F; Receptors, Adrenergic, alpha; Support, Non-U.S. Gov't; Vas Deferens; Yohimbine
Año:1983
Volumen:26
Número:5
Página de inicio:701
Página de fin:710
DOI: http://dx.doi.org/10.1016/0090-6980(83)90055-2
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; indometacin, 53-86-1, 74252-25-8, 7681-54-1; methoxamine, 390-28-3, 61-16-5; phenoxybenzamine, 59-96-1, 63-92-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha trometamol, 38562-01-5; yohimbine, 146-48-5, 65-19-0; Aspirin, 50-78-2; Cyclooxygenase Inhibitors; Indomethacin, 53-86-1; Methoxamine, 390-28-3; Phenoxybenzamine, 59-96-1; Prostaglandins E; Prostaglandins F; Receptors, Adrenergic, alpha; Yohimbine, 146-48-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v26_n5_p701_Borda

Referencias:

  • Baumgarten, Owman, Sjöstrand, (1974) Control of Male Fertility, pp. 26-40. , J.J. Sciarra, C. Markland, J.J. Speidel, Hagerstown, MD
  • Sjöstrand, The adrenergic innervation of the vas deferens and the male genital tract (1965) Acta physiol. scand. Suppl., 257
  • Owman, Sjöstrand, Short adrenergic neurons and catecholamines containing cells in vas deferens and accessory male genital glands of different mammals (1965) Anat., 66, p. 300
  • Borda, del C. Agostini, Gimeno, Gimeno, Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens (1981) Pharm. Res. Commun., 13, p. 981
  • Borda, Agostini, Peredo, Gimeno, Gimeno, Contractile activity of the isolated rat vas deferens and release of PGE and F-like substance. Influence of acetylcholine and inhibitors of cyclooxygenase and phospholipase A2 (1983) Arch. int. Pharmacodyn., , (in press)
  • Bartke, Koerner, Androgenic regulation of the concentration of PGF in the male reproductive system of rats and mice (1974) Endocrinology, 95, p. 1739
  • Badr, Effect of sexual maturation and androgens on prostaglandin levels in tissue of the male reproductive system in mice (1976) Endocrinology, 98, p. 1523
  • Mantegazza, Naimzada, Attivita della prostaglandins E1 sul preparato nervo ipogastrico-deferente di varie specie animali (1965) Atti. Med. Lomb., 20, p. 58
  • Hib, Oscar, Effects of prostaglandins and indomethacin on rat epididymal responses to norepinephrine and acetylcholine (1972) Biol. of Reprod., 6, p. 224
  • Vane, The use of isolated organs for detection of active substances in the circulating blood (1964) Br. J. Pharmacol. Chemother., 23, p. 360
  • Gilmore, Vane, Willie, Prostaglandins released by the spleen (1968) Nature (Lond.), 218, p. 1135
  • Van Rossum, Cumulative dose-response curves (1963) Arch. intern. Pharmacodyn. Ther., 143, p. 299
  • Flower, Drugs which inhibit prostaglandin biosyntesis (1974) Pharmacol. Rev., 26, p. 33
  • Langer, Presynaptic regulation of the release of the catecholamines (1981) Pharmacol. Rev., 32, p. 337
  • Fain, Lin, Litosch, Wallace, Hormonal regulation of phosphotidylinositol breakdown (1983) Life Sci., 32, p. 2054
  • Griffiths, Moore, Interaction of prostaglandins and clonidine in the rat deferens (1982) J. Pharm. Pharmacol., 34, p. 724
  • Levine, Moskowitz, Alpha and beta adrenergic stimulation of arachidonic acid metabolism in cells in culture (1979) Proc. Natl. Acad. Sci. (USA), 76, p. 6632
  • Marley, Smith, Mating increases the PG-like content of male and female reproductive tracts in mice (1974) J. Endocrinol., 61, p. 34
  • Guey-Bin Chang, Sun, Hsiung Tai, PG 9-ketoreductase and type II 15-hydroxyprostaglandin dehydrogenase from swine kidney are alterate activities of a single enzyme protein (1981) Biochemical and Biophysical Research Communications, 99, p. 745
  • Kröner, Peskar, RIA for 15 methyl PGE2 and F2 use for the measurement of rat brain prostaglandin 9-ketoreductase (1976) Arch. int. Pharmacol., 274, p. 16

Citas:

---------- APA ----------
Borda, E.S., Peredo, H. & Gimeno, M.F. (1983) . Alpha adrenergic stimulation modified prostaglandins release in vas deferens. Prostaglandins, 26(5), 701-710.
http://dx.doi.org/10.1016/0090-6980(83)90055-2
---------- CHICAGO ----------
Borda, E.S., Peredo, H., Gimeno, M.F. "Alpha adrenergic stimulation modified prostaglandins release in vas deferens" . Prostaglandins 26, no. 5 (1983) : 701-710.
http://dx.doi.org/10.1016/0090-6980(83)90055-2
---------- MLA ----------
Borda, E.S., Peredo, H., Gimeno, M.F. "Alpha adrenergic stimulation modified prostaglandins release in vas deferens" . Prostaglandins, vol. 26, no. 5, 1983, pp. 701-710.
http://dx.doi.org/10.1016/0090-6980(83)90055-2
---------- VANCOUVER ----------
Borda, E.S., Peredo, H., Gimeno, M.F. Alpha adrenergic stimulation modified prostaglandins release in vas deferens. Prostaglandins. 1983;26(5):701-710.
http://dx.doi.org/10.1016/0090-6980(83)90055-2