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Abstract:

Dose-response curves for several prostaglandins (PGI2; PGD2; PGF2 and PGE2); BaCl2 or prostaglandin metabolites (15-keto-PGF2α; 13, 14-diOH-15-keto-PGF2α; 6-keto-PGF1α and 6-keto-PGE1 in quiescent (indomethacin-treated) uterine strips from ovariectomized rats, were constructed. All PGs tested as well as BaCl2, triggered at different concentrations, evident phasic contractions. Within the range of concentrations tested the portion of the curves for the metabolites of PGF2α was shifted to the right of that for PGF2α itself; the curve for 6-keto-PGF1α was displaced to the right of the curve for PGI2 and that for 6-keto-PGE1 to the left. It was also demonstrated that the uterine motility elicited by 10-5 M PGF2α and its metabolites was long lasting (more than 3 hours) and so it was the activity evoked by PGI2; 6-keto-PGF1α and BaCl2, but not the contractions following 6-keto-PGE1, which disappeared much earlier. The contractile tension after PGF2α; 15-keto-PGF2α; 13, 14-diOH-15-keto-PGF2α and PGI2, increased as time progressed whilst that evoked by 6-keto-PGF2α or BaCl2 fluctuated during the same period around more constant levels. The surprising sustained and gradually increasing contractile activity after a single dose of an unstable prostaglandin such as PGI2, on the isolated rat uterus rendered quiescent by indomethacin, is discussed in terms of an effect associated to its transformation into more stable metabolites (6-keto-PGF1α, or another not tested) or as a consequence of a factor which might protects prostacyclin from inactivation. © 1983.

Registro:

Documento: Artículo
Título:Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats
Autor:Gimeno, A.L.; Chaud, M.; Bonacossa, A.; Franchi, A.M.; Gimeno, M.F.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina
Palabras clave:barium chloride; indometacin; prostacyclin; prostaglandin d2; prostaglandin e2; prostaglandin f2 alpha; animal cell; biological model; dose response; dose time effect relation; drug administration; drug comparison; drug efficacy; drug response; female genital system; methodology; myometrium; nonhuman; rat; uterus contractility; Animals; Barium; Barium Compounds; Castration; Chlorides; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Female; Indomethacin; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Uterine Contraction; Animalia
Año:1983
Volumen:26
Número:4
Página de inicio:663
Página de fin:676
DOI: http://dx.doi.org/10.1016/0090-6980(83)90202-2
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:barium chloride, 10361-37-2; indometacin, 53-86-1, 74252-25-8, 7681-54-1; prostacyclin, 35121-78-9, 61849-14-7; prostaglandin D2, 41598-07-6; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Barium, 7440-39-3; Barium Compounds; Chlorides; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Epoprostenol, 35121-78-9; Indomethacin, 53-86-1; Prostaglandin D2, 41598-07-6; Prostaglandins D; Prostaglandins E; Prostaglandins F; barium chloride, 10361-37-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v26_n4_p663_Gimeno

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Citas:

---------- APA ----------
Gimeno, A.L., Chaud, M., Bonacossa, A., Franchi, A.M. & Gimeno, M.F. (1983) . Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. Prostaglandins, 26(4), 663-676.
http://dx.doi.org/10.1016/0090-6980(83)90202-2
---------- CHICAGO ----------
Gimeno, A.L., Chaud, M., Bonacossa, A., Franchi, A.M., Gimeno, M.F. "Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats" . Prostaglandins 26, no. 4 (1983) : 663-676.
http://dx.doi.org/10.1016/0090-6980(83)90202-2
---------- MLA ----------
Gimeno, A.L., Chaud, M., Bonacossa, A., Franchi, A.M., Gimeno, M.F. "Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats" . Prostaglandins, vol. 26, no. 4, 1983, pp. 663-676.
http://dx.doi.org/10.1016/0090-6980(83)90202-2
---------- VANCOUVER ----------
Gimeno, A.L., Chaud, M., Bonacossa, A., Franchi, A.M., Gimeno, M.F. Prostacyclin induces a surprising long-lasting motility in quiescent uterine strips (indomethacin-treated) isolated from ovariectomized rats. Prostaglandins. 1983;26(4):663-676.
http://dx.doi.org/10.1016/0090-6980(83)90202-2