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Abstract:

The output of prostaglandin (PG) F and PGE-like material into the solution bathing uterine horns isolated from adult ovariectomized and immature rats under the influence of progesterone, was studied. The injection of progesterone (0.5; 1.0; 2.0 or 4.0 mg) hours prior to sacrifice enhanced significantly the release of PGF-like substance without modifying that of PGE. The augmentation of PGF was detected as early as one hour after injecting 4.0 mg of progesterone and remained elevated at 2,4,6, 12 and 24 hours, following the treatment. Puromycin (50 mg/Kg), injected 6 hours before killing, failed to alter the release of PGF-like substance but clearly blocked the stimulating effect of the hormone. In addition, progesterone also enhanced significantly the release of PGF-like material by horns isolated from immature animals. The results suggest that progesterone receptors do not appear to be important for the described effect of the hormone because the preparations employed in the present study have a very small content of these receptors. Alternatively, it can be hypothesized that only a reduced number of progesterone receptors are sufficient for the action of the hormone augmenting the output of PGF-like material from the uterus. © 1983.

Registro:

Documento: Artículo
Título:Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats
Autor:Franchi, A.M.; Gonzalez, E.T.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Re, 1414 Buenos Aires, Argentina
Palabras clave:indometacin; progesterone; prostaglandin f2 alpha; puromycin; age; animal experiment; drug efficacy; endocrine system; female genital system; nonhuman; ovariectomy; rat; uterus; Aging; Animal; Castration; Dinoprost; Dose-Response Relationship, Drug; Female; Kinetics; Progesterone; Prostaglandins F; Puromycin; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uterus
Año:1982
Volumen:24
Número:6
Página de inicio:775
Página de fin:787
DOI: http://dx.doi.org/10.1016/0090-6980(82)90058-2
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:indometacin, 53-86-1, 74252-25-8, 7681-54-1; progesterone, 57-83-0; prostaglandin F2 alpha, 551-11-1; puromycin, 53-79-2, 58-58-2; Dinoprost, 551-11-1; Progesterone, 57-83-0; Prostaglandins F; Puromycin, 53-79-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v24_n6_p775_Franchi

Referencias:

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  • Gimeno, Borda, Lazzari, Gimeno, Ovarian hormones inhibit the release of prostacyclin (PGI2) from isolated rat uterus (1980) Prostaglandins, 20, p. 233
  • Franchi, Bonacossa, Gimeno, Gimeno, Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated and prostaglandin synthesis in uterine horns isolated from ovariectomized rats (1982) Prostaglandins, 23, p. 819
  • Leavitt, Chen, Allen, Regulation of progesterone receptor formation by estrogen action (1977) Ann. N.Y. Acad. Sci., 286, pp. 210-225
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Citas:

---------- APA ----------
Franchi, A.M., Gonzalez, E.T., Gimeno, M.F. & Gimeno, A.L. (1982) . Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats. Prostaglandins, 24(6), 775-787.
http://dx.doi.org/10.1016/0090-6980(82)90058-2
---------- CHICAGO ----------
Franchi, A.M., Gonzalez, E.T., Gimeno, M.F., Gimeno, A.L. "Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats" . Prostaglandins 24, no. 6 (1982) : 775-787.
http://dx.doi.org/10.1016/0090-6980(82)90058-2
---------- MLA ----------
Franchi, A.M., Gonzalez, E.T., Gimeno, M.F., Gimeno, A.L. "Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats" . Prostaglandins, vol. 24, no. 6, 1982, pp. 775-787.
http://dx.doi.org/10.1016/0090-6980(82)90058-2
---------- VANCOUVER ----------
Franchi, A.M., Gonzalez, E.T., Gimeno, M.F., Gimeno, A.L. Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats. Prostaglandins. 1982;24(6):775-787.
http://dx.doi.org/10.1016/0090-6980(82)90058-2