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Abstract:

The motility of isolated uterine horns as well as the generation of PGE and PGF-like material by uterus from spayed rats, treated or untreated with progesterone or progesterone plus estradiol-17-beta, were studied. The changes of Functional Activity (FA) with time (constancy) of control uterine horns and that preparations treated wtih 2 mg of progesterone (P) were not significantly different. However, the PGF-like material released into the bathing solution was significantly higher when the animals were treated with P. PGE-like material in the medium was similar in both groups. With higher doses to P (4 mg/day/2 days) the constancy of FA was similar to that observed in untreated animals, and the PGF-like material released into the medium was significantly higher than in the control group FA and PGs releases into the bathing medium by uterine horns from supra-renalectomized-ovariectomized animals (treated or not with P) were similar to those obtained in spayed rats with the intact suprarenal gland, but the absolute values of PGF-like material were always lower than in this group. Estradiol-17-beta injected prior or after P diminished the stimulation induced by P on the release of PGF-like material into the medium. The constancy of the contractile activity as well as the uterine release of PGE-like material was also diminished in rats treated with P plus estradiol-17-beta. The novel finding that progesterone stimulates the synthesis of PGF in uterine horns from ovariectomized rats without changing that of PGE is discussed. © 1982.

Registro:

Documento: Artículo
Título:Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from ovariectomized rats
Autor:Franchi, A.M.; Bonacossa, A.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (Cefaprin) Conicet, V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:alcohol; estradiol; progesterone; prostaglandin; sesame seed oil; adrenalectomy; controlled study; dose time effect relation; drug mechanism; drug mixture; endocrine system; female genital system; nonhuman; rat; subcutaneous drug administration; uterus contractility; Animal; Castration; Dose-Response Relationship, Drug; Estradiol; Female; Progesterone; Prostaglandins; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uterine Contraction; Uterus
Año:1982
Volumen:23
Número:6
Página de inicio:819
Página de fin:832
DOI: http://dx.doi.org/10.1016/0090-6980(82)90126-5
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:alcohol, 64-17-5; estradiol, 50-28-2; progesterone, 57-83-0; sesame seed oil, 8008-74-0; Estradiol, 50-28-2; Progesterone, 57-83-0; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v23_n6_p819_Franchi

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Citas:

---------- APA ----------
Franchi, A.M., Bonacossa, A., Gimeno, M.F. & Gimeno, A.L. (1982) . Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from ovariectomized rats. Prostaglandins, 23(6), 819-832.
http://dx.doi.org/10.1016/0090-6980(82)90126-5
---------- CHICAGO ----------
Franchi, A.M., Bonacossa, A., Gimeno, M.F., Gimeno, A.L. "Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from ovariectomized rats" . Prostaglandins 23, no. 6 (1982) : 819-832.
http://dx.doi.org/10.1016/0090-6980(82)90126-5
---------- MLA ----------
Franchi, A.M., Bonacossa, A., Gimeno, M.F., Gimeno, A.L. "Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from ovariectomized rats" . Prostaglandins, vol. 23, no. 6, 1982, pp. 819-832.
http://dx.doi.org/10.1016/0090-6980(82)90126-5
---------- VANCOUVER ----------
Franchi, A.M., Bonacossa, A., Gimeno, M.F., Gimeno, A.L. Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from ovariectomized rats. Prostaglandins. 1982;23(6):819-832.
http://dx.doi.org/10.1016/0090-6980(82)90126-5