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Abstract:

Isolated coronary arteries from diabetic dogs presented different contractile response to U-46619 to prostacyclin (PGI2) and to arachidonic acid (AA) than those of normal dogs. The stimulatory effect of the synthetic endoperoxide analogue U-46619, was significantly higher in the diabetic condition than in preparations from normal animals. On the other hand, while PGI2 evoked a dose-dependent relaxation of normal coronary arteries, diabetic vessels were not relaxed by low concentration of PGI2 whereas higher ones produced a distinct constrictor effect. Additionally, inhibitors of prostaglandins and thromboxane (TX) biosynthesis such as corticosterone, indomethacin, acetylsalicylic acid, imidazole and L-8027, abolished the stimulatory effect of PGI2 in coronary arteries from diabetic dogs. AA relaxed coronaries from normal dogs and constricted those from diabetic animals, this action being inhibited by imidazol and L-8027. The present results suggests that: a) coronary vessels from diabetic dogs are more reactive to an endoperoxide analogue than normal preparations and b) PGI2 and AA probably contract diabetic coronary arteries via the participation of a TX like material. It is then plausible that this effect could be tentatively ascribed to the production of a prostaglandin constricting substance including als the probable generation of a TXA2-like agonist. © 1981.

Registro:

Documento: Artículo
Título:Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis
Autor:Sterin-Borda, L.; Gimeno, M.; Borda, E.; del Castillo, E.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), the Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) de la Republica Argentina, Instituto de Biología y Medicina Experimental. V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:15 Hydroxy 11 alpha,9 alpha (epoxymethano)prosta 5,13 dienoic Acid; 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; acetylsalicylic acid; Anti Inflammatory Agents; antiinflammatory agent; corticosterone; imidazole; imidazole derivative; indole derivative; indometacin; nictindole; prostacyclin; prostaglandin; prostaglandin endoperoxide; pyridine derivative; 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; acetylsalicylic acid; arachidonic acid; endoperoxide analog; imidazole; indometacin; nictindole; prostacyclin; thromboxane; unclassified drug; animal; article; coronary blood vessel; dog; dose response; drug effect; experimental diabetes mellitus; kinetics; pancreas resection; pathophysiology; animal experiment; coronary artery; diabetes mellitus; dose; drug comparison; drug response; endocrine system; great blood vessel; in vitro study; vasoconstriction; vasodilatation; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animal; Anti-Inflammatory Agents; Aspirin; Coronary Vessels; Corticosterone; Diabetes Mellitus, Experimental; Dogs; Dose-Response Relationship, Drug; Epoprostenol; Imidazoles; Indoles; Indomethacin; Kinetics; Pancreatectomy; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyridines; Animalia; Canis familiaris
Año:1981
Volumen:22
Número:2
Página de inicio:267
Página de fin:278
DOI: http://dx.doi.org/10.1016/0090-6980(81)90041-1
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid, 56985-40-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; corticosterone, 50-22-6; imidazole, 1467-16-9, 288-32-4; indometacin, 53-86-1, 74252-25-8, 7681-54-1; nictindole, 36504-64-0; prostacyclin, 35121-78-9, 61849-14-7; arachidonic acid, 506-32-1, 6610-25-9, 7771-44-0; thromboxane, 66719-58-2; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, 76898-47-0; Anti-Inflammatory Agents; Aspirin, 50-78-2; Corticosterone, 50-22-6; Epoprostenol, 35121-78-9; imidazole, 288-32-4; Imidazoles; Indoles; Indomethacin, 53-86-1; nictindole, 36504-64-0; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyridines
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v22_n2_p267_SterinBorda

Referencias:

  • Moncada, Higgs, Vane, Human art rial and venous tissues generate prostacyclin (Prostaglandin X) a potent inhibitor of platelet aggregation (1977) Lancet, 1, p. 18
  • De Deckere, Nugteren, Ten Hoor, Prostacyclin in the major prostaglandin released from isolated perfused rabbit and rat heart (1977) Nature, 268, p. 160
  • Dusting, Moncada, Vane, Prostacyclin is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid (1977) Prostaglandins, 13, p. 3
  • Schör, Rosën, Prostacyclin (PGI2) decreases the cyclic AMP level in coronary arteries (1979) Naunyn-Schmiedeberg's Archives of Pharmacology, 306, p. 101
  • Ogletree, Smith, Lefer, Actions of prostaglandins on is lated perfused cat coronary arteries (1978) Am. J. Physiol., 235, p. 400
  • Bomerantz, Sintetos, Ramwell, The effect of prostacyclin on the human umbilical artery (1978) Prostaglandins, 15, p. 1035
  • Chapeau, White, Effects of prostacyclin on the canine isolated basilar artery (1979) Prostaglandins, 17, p. 573
  • Toda, Responses to prostaglandins H2 and I2 of isolated dog cerebral and peripheral arteries (1980) J. Am. J. Physiol., 238, p. 111
  • Borda, Agostini, Sterin-Speziale, Gimeno, Gimeno, Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) (1979) Prostaglandins, 18, p. 829
  • Higgs, Bunting, Moncada, Vane, Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis (1976) Prostaglandins, 12, p. 749
  • Wolfe, Rostworoski, Marion, Endogenous formation of prostaglandin endoperoxide metabolite Thromboxane B2 by brain tissue (1976) Biochem. Biophys. Res. Commun., 70, p. 907
  • Nijkamp, Moncada, White, Vane, Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets (1977) European Journal of Pharmacology, 44, p. 79
  • Tuvemo, Action of prostaglandins and blockers of prostaglandin synthesis on the isolated human umbilical artery (1978) Adv. Prostagl. Thrombox. Res., 4, p. 271
  • Ellis, Oelz, Roberts, Payne, Sweetman, Nies, Oates, Coronary arterial smooth muscle contraction by a substance released from platelets. Evidence that it is thromboxane A2 (1976) Science, 193, p. 1135
  • Needleman, Kulkerni, Raz, Coronary tone modulation, formation and actions of prostaglandins, endoperoxides and thromboxanes (1977) Science, 195, p. 409
  • Bern, Platelet functions in diabetic mellitus (1978) Diabetes, 27, p. 342
  • Colwell, Chambere, Laimin, Increased platelet aggregation in early diabetes (1975) Diabetes, 24, p. 684
  • Owen, Carrier, Alteration in vascular smooth muscle sensitivity to vasocontrictor agents by streptozotocin induced diabetes (1979) Proc. Wes. Pharmacol. Soc., 22, p. 363
  • Owen, Carrier, Calcium dependence of norepinephrine-induced vascular contraction experimental diabetes (1980) J. Pharmacol. exp. Ther., 212, p. 253
  • Sanger, Bennett, Regional differences in the responses to prostanoids of circular muscle from guinea pig isolated intestine (1980) J. Pharm. Pharmacol., 32, p. 705
  • del Castillo, Galli, Roldan, Rietti, Houssay, Decrease in ketonemia due to infusion of lipids in pancreatectomized dogs (1965) Diabetes, 14, p. 33
  • Sterin-Borda, Gimeno, Gimeno, Frequency-force relationship on isolated rat and guinea pig atria. Effect of cholinergic and adrenergic receptor antagonists (1974) Proc. Soc. Exp. Biol. Med., 145, p. 1151
  • Borda, Schuchleib, Henry, Effect of potassium on isolated canine coronary arteries (1977) Circulation Res., 41, p. 778
  • Borda, Schuchleib, Henry, Hypoxic contraction of isolated canine coronary artery. Mediation by potassium-dependent exocytosis of norepinephrine (1980) Circulation Res., 46, p. 870
  • Gimeno, Sterin-Borda, Borda, Lazzari, Gimeno, Human plasma transforms prostacyclin (PGI2) into a platele antiaggregatory substance which contracts isolated bovine coronary arteries (1980) Prostaglandins, 19, p. 907
  • Raz, Isakson, Minkes, Needleman, Characterization of a novel metabolic pathway of arachidonate in coronary arteries which generates a potent endogenous coronary vasodilator (1977) J. Biol. Chem., 252, p. 1123
  • Ogletree, Smith, Lefer, Actions of prostaglandins on isolated perfused rat coronary arteries (1978) Am. J. Physiol., 235, p. 400
  • Needleman, Bronson, Wiche, Sivakoff, Nicolaou, Cardiac and renal prostaglandin I2. Biosynthesis and biological effect in isolated perfused rabbit tissue (1978) J. Clin. Invest., 61, p. 839
  • Coleman, Humphrey, Kennedy, Levy, Lumley, U-46619, a selective thromboxane A2-like agonist? (1980) British Journal of Pharmacology, 68, p. 127P
  • Dusting, Moncada, Vane, Recirculation of prostacyclin (PGI2) in the dog (1978) Brit. J. Pharmacol., 64, p. 315
  • Fitzpatrick, Alter, Corey, Ramwell, Rose, Kot, Cardiovascular responses to PGI2 (prostacyclin) in the dog (1978) Circulation Res., 42, p. 192
  • Dusting, Moncada, Vane, Prostacyclin (PGI2) is a weak contractor of coronary arteries of the pig (1977) Europ. J. Pharmacol., 45, p. 301
  • Moncada, Bunting, Mullane, Thorogood, Vane, Imidazole: a selective inhibitor of thromboxane synthetase (1977) Prostaglandins, 13, p. 611
  • Gryglewski, Prostaglandin and Thromboxane Biosynthesis Inhibitors (1977) Naunyn-Schmiedeberg's Arch. Pharmacol., 297, p. 585
  • Needleman, Minkes, Raz, Thromboxanes: selective biosynthesis and distinct biological properties (1976) Science, 193, p. 163
  • Vane, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs (1971) Nature (New Biol.), 231, p. 232
  • Flower, Drugs which inhibit prostaglandin biosynthesis (1974) Pharm. Rev., 26, p. 33

Citas:

---------- APA ----------
Sterin-Borda, L., Gimeno, M., Borda, E., del Castillo, E. & Gimeno, A.L. (1981) . Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis. Prostaglandins, 22(2), 267-278.
http://dx.doi.org/10.1016/0090-6980(81)90041-1
---------- CHICAGO ----------
Sterin-Borda, L., Gimeno, M., Borda, E., del Castillo, E., Gimeno, A.L. "Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis" . Prostaglandins 22, no. 2 (1981) : 267-278.
http://dx.doi.org/10.1016/0090-6980(81)90041-1
---------- MLA ----------
Sterin-Borda, L., Gimeno, M., Borda, E., del Castillo, E., Gimeno, A.L. "Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis" . Prostaglandins, vol. 22, no. 2, 1981, pp. 267-278.
http://dx.doi.org/10.1016/0090-6980(81)90041-1
---------- VANCOUVER ----------
Sterin-Borda, L., Gimeno, M., Borda, E., del Castillo, E., Gimeno, A.L. Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis. Prostaglandins. 1981;22(2):267-278.
http://dx.doi.org/10.1016/0090-6980(81)90041-1