Artículo
Sterin-Borda, L.; Canga, L.; Pissani, A.; Gimeno, A.L. "Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms" (1980) Prostaglandins. 20(5):825-836
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Abstract:
The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified. © 1980, All rights reserved.
Registro:
| Documento: | Artículo |
| Título: | Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms |
| Autor: | Sterin-Borda, L.; Canga, L.; Pissani, A.; Gimeno, A.L. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V. de Obligado 2490, Buenos Aires, 1428, Argentina |
| Palabras clave: | Adrenergic alpha Agonists; Adrenergic beta Agonists; alpha adrenergic receptor stimulating agent; beta adrenergic receptor stimulating agent; methoxamine; noradrenalin; prostaglandin E; methoxamine; noradrenalin; phenoxybenzamine; phentolamine; propranolol; prostaglandin E1; prostaglandin E2; animal; article; dose response; drug effect; heart atrium; heart contraction; in vitro study; male; rat; adrenergic system; animal experiment; autonomic nervous system; drug comparison; heart; heart atrium; heart atrium contraction; heart contraction; heart inotropic effect; inotropism; isolated heart; preliminary communication; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animal; Dose-Response Relationship, Drug; Heart Atrium; In Vitro; Male; Methoxamine; Myocardial Contraction; Norepinephrine; Prostaglandins E; Rats; Support, Non-U.S. Gov't; Animalia |
| Año: | 1980 |
| Volumen: | 20 |
| Número: | 5 |
| Página de inicio: | 825 |
| Página de fin: | 836 |
| DOI: | http://dx.doi.org/10.1016/0090-6980(80)90136-7 |
| Título revista: | Prostaglandins |
| Título revista abreviado: | Prostaglandins |
| ISSN: | 00906980 |
| CAS: | methoxamine, 390-28-3, 61-16-5; noradrenalin, 1407-84-7, 51-41-2; prostaglandin E, 11042-70-9; phenoxybenzamine, 59-96-1, 63-92-3; phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Methoxamine, 390-28-3; Norepinephrine, 51-41-2; Prostaglandins E |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v20_n5_p825_SterinBorda |
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Citas:
---------- APA ----------
Sterin-Borda, L., Canga, L., Pissani, A. & Gimeno, A.L. (1980) . Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms. Prostaglandins, 20(5), 825-836.http://dx.doi.org/10.1016/0090-6980(80)90136-7
---------- CHICAGO ----------
Sterin-Borda, L., Canga, L., Pissani, A., Gimeno, A.L. "Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms" . Prostaglandins 20, no. 5 (1980) : 825-836.http://dx.doi.org/10.1016/0090-6980(80)90136-7
---------- MLA ----------
Sterin-Borda, L., Canga, L., Pissani, A., Gimeno, A.L. "Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms" . Prostaglandins, vol. 20, no. 5, 1980, pp. 825-836.http://dx.doi.org/10.1016/0090-6980(80)90136-7
---------- VANCOUVER ----------
Sterin-Borda, L., Canga, L., Pissani, A., Gimeno, A.L. Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms. Prostaglandins. 1980;20(5):825-836.http://dx.doi.org/10.1016/0090-6980(80)90136-7
