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Abstract:

The motility of isolated uterine horns as well as the generation of PGE and PGF like material by the uterus from estrus and spayed rats, treated or untreated with 17-beta estradicl, were studied. Following 40 minutes of mounting the spontaneous motility of uteri from estrus rats had a lower magnitude than that from spayed ones. The amount of PGF-like material was similar in both groups whereas the first one liberated less PGE-like substance. In spayed animals treated with 1 μg of 17-beta estradiol the decay of spontaneous contractile force was higher than that observed in untreated rats, and similar to that displayed by uteri from estrus. Less PGE-like material was liberated in comparison with spayed animals and a tendency to produce higher quantity of PGF-like compounds was observed, although the level was not significantly different. With 50 μg of 17-beta estradiol the spontaneous reduction of contractile activity was higher than in spayed animals and than in those treated with 1 μg. The amount of PGF-like material liberated was higher than in spayed rats and less PGE-like substance was generated comparing with spayed and 1 μg-treated animals. These findings show that estradiol decreases the release of PGE-like compound. It would also appear that this may have some relationship with the levels of spontaneous contractile activity of the isolated rat uterus. © 1980.

Registro:

Documento: Artículo
Título:The effect of estradiol on isolated rat uterine motility and on prostaglandin generation
Autor:Sterin-Speziale, N.; Gimeno, M.F.; Bonacossa, A.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V.de Obligado 2490., 1428 Buenos Aires, Argentina
Palabras clave:estradiol; prostaglandin; prostaglandin e; prostaglandin f; animal experiment; female genital system; preliminary communication; rat; subcutaneous drug administration; uterus; uterus contractility; Animal; Castration; Dose-Response Relationship, Drug; Estradiol; Estrus; Female; Pregnancy; Prostaglandins E; Prostaglandins F; Rats; Uterine Contraction; Uterus
Año:1980
Volumen:20
Número:2
Página de inicio:233
Página de fin:243
DOI: http://dx.doi.org/10.1016/S0090-6980(80)80042-6
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:estradiol, 50-28-2; prostaglandin E, 11042-70-9; Estradiol, 50-28-2; Prostaglandins E; Prostaglandins F
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v20_n2_p233_SterinSpeziale

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Citas:

---------- APA ----------
Sterin-Speziale, N., Gimeno, M.F., Bonacossa, A. & Gimeno, A.L. (1980) . The effect of estradiol on isolated rat uterine motility and on prostaglandin generation. Prostaglandins, 20(2), 233-243.
http://dx.doi.org/10.1016/S0090-6980(80)80042-6
---------- CHICAGO ----------
Sterin-Speziale, N., Gimeno, M.F., Bonacossa, A., Gimeno, A.L. "The effect of estradiol on isolated rat uterine motility and on prostaglandin generation" . Prostaglandins 20, no. 2 (1980) : 233-243.
http://dx.doi.org/10.1016/S0090-6980(80)80042-6
---------- MLA ----------
Sterin-Speziale, N., Gimeno, M.F., Bonacossa, A., Gimeno, A.L. "The effect of estradiol on isolated rat uterine motility and on prostaglandin generation" . Prostaglandins, vol. 20, no. 2, 1980, pp. 233-243.
http://dx.doi.org/10.1016/S0090-6980(80)80042-6
---------- VANCOUVER ----------
Sterin-Speziale, N., Gimeno, M.F., Bonacossa, A., Gimeno, A.L. The effect of estradiol on isolated rat uterine motility and on prostaglandin generation. Prostaglandins. 1980;20(2):233-243.
http://dx.doi.org/10.1016/S0090-6980(80)80042-6