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Abstract:

The influence of sex steroids on the production of prostacyclin (PGI2) like material by the isolated rat uterus incubated in a buffer medium was explored by monitoring its ability to inhibit ADP-induced platelet aggregation. Chopped uterine strips from rats in natural estrus can generate an unstable substance that inhibits platelet aggregation and suggest to be prostacyclin. This capacity was significantly enhanced in preparations from spayed animals. The injection of 17-beta estradiol; progesterone or both diminished the production of the prostacyclin-like material by the uterus from ovariectomized rats. The already existing notion that ovarian steroids are able to regulate the synthesis of stable prostaglandins is discussed together with the present results suggesting in addition a depressive effect of sex hormones on the uterine PGI2 synthetase system. © 1980.

Registro:

Documento: Artículo
Título:Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus
Autor:Gimeno, M.F.; Borda, E.S.; Lazzari, M.A.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V. de Obligado 2490., 1428 Buenos Aires, Argentina
Instituto de Investigaciones Hemato-logicas. Academia Nacional de Medicina. Pacheco de Melo 3081., 1425 Buenos Aires, Argentina
Palabras clave:estradiol; progesterone; prostacyclin; prostaglandin; sex hormone; animal experiment; blood and hemopoietic system; drug release; endocrine system; female genital system; intraperitoneal drug administration; preliminary communication; rat; thrombocyte aggregation; uterus; Adenosine Diphosphate; Animal; Castration; Epoprostenol; Estradiol; Estrus; Female; Platelet Aggregation; Pregnancy; Prostaglandins; Rats; Uterus; Animalia
Año:1980
Volumen:20
Número:2
Página de inicio:223
Página de fin:232
DOI: http://dx.doi.org/10.1016/S0090-6980(80)80041-4
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:estradiol, 50-28-2; progesterone, 57-83-0; prostacyclin, 35121-78-9, 61849-14-7; Adenosine Diphosphate, 58-64-0; Epoprostenol, 35121-78-9; Estradiol, 50-28-2; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v20_n2_p223_Gimeno

Referencias:

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Citas:

---------- APA ----------
Gimeno, M.F., Borda, E.S., Lazzari, M.A. & Gimeno, A.L. (1980) . Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus. Prostaglandins, 20(2), 223-232.
http://dx.doi.org/10.1016/S0090-6980(80)80041-4
---------- CHICAGO ----------
Gimeno, M.F., Borda, E.S., Lazzari, M.A., Gimeno, A.L. "Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus" . Prostaglandins 20, no. 2 (1980) : 223-232.
http://dx.doi.org/10.1016/S0090-6980(80)80041-4
---------- MLA ----------
Gimeno, M.F., Borda, E.S., Lazzari, M.A., Gimeno, A.L. "Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus" . Prostaglandins, vol. 20, no. 2, 1980, pp. 223-232.
http://dx.doi.org/10.1016/S0090-6980(80)80041-4
---------- VANCOUVER ----------
Gimeno, M.F., Borda, E.S., Lazzari, M.A., Gimeno, A.L. Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus. Prostaglandins. 1980;20(2):223-232.
http://dx.doi.org/10.1016/S0090-6980(80)80041-4