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Abstract:

Prostacyclin (PGI2) incubated in Human Platelet Rich Plasma (PRP); in Platelet Poor Plasma (PPP) or in Krebs-Ringer-Bicarbonate (KRB) during different periods of time on contractions of bovine coronary arteries and on the ADP platelet aggregative capacity of human PRP, were explored. It was documented that incubates in PRP or in PPP retain an antiaggregatory activity at higher levels and during a longer time than in KRB. On the other hand, PGI2 incubates in KRB exhibited only a relaxing activity on isolated bovine coronary arteries, whereas when incubated in PRP or in PPP presented a biphasic influence. The initial effects (evoked by incubates of 30 minutes) were distinctly relaxing but those obtained with later incubates (60-150 minutes) stimulated clearly the resting basal tone of the arteries. The possibility that the human plasma might have an enzyme(s) able to transform prostacyclin into a more stable material with human antiaggregatory platelet function and bovine coronary contracting capacity is discussed. © 1980.

Registro:

Documento: Artículo
Título:Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries
Autor:Gimeno, M.F.; Sterin-Borda, L.; Borda, E.S.; Lazzari, M.A.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos, y de Principios Naturales (CEFAPRIN), 1428 Buenos Aires, CONICET, V. de Obligado 2490, 1428 Buenos Aires, Argentina USA
Instituto de Investigaciones Hematológicas. Academia Nacional de Medicina. Pacheco de Melo 3081, 1425 Buenos Aires, Argentina USA
Palabras clave:6 oxoprostaglandin e1; 6 oxoprostaglandin f1 alpha; prostacyclin; animal experiment; blood and hemopoietic system; cattle; coronary artery; coronary artery obstruction; drug metabolism; heart; heart muscle ischemia; in vitro study; peripheral vascular system; plasma; smooth muscle contractility; thrombocyte; thrombocyte aggregation; thrombosis; vasoconstriction; 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Anticoagulants; Blood Platelets; Blood Proteins; Cattle; Coronary Vessels; Epoprostenol; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandins; Prostaglandins F; Prostaglandins, Synthetic
Año:1980
Volumen:19
Número:6
Página de inicio:907
Página de fin:916
DOI: http://dx.doi.org/10.1016/0090-6980(80)90125-2
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:6 oxoprostaglandin E1, 67786-53-2; prostacyclin, 35121-78-9, 61849-14-7; 6-Ketoprostaglandin F1 alpha, 58962-34-8; Adenosine Diphosphate, 58-64-0; Anticoagulants; Blood Proteins; Epoprostenol, 35121-78-9; Prostaglandins; Prostaglandins F; Prostaglandins, Synthetic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v19_n6_p907_Gimeno

Referencias:

  • Borda, E.S., M.A. Lazzari, M.F. Gimeno and A.L. Gimeno. Human Platelet Rich Plasma and Human Serum protects from inactivation the antiaggregatory capacity of prostacyclin like material (PGI2) produced by the rat stomach fundus. Prostaglandins; Johnson, Morton, Kinner, Gorman, Guire, Sun, Whittaker, Vane, The chemical characterization of prostaglandin X (prostacyclin) (1976) Prostaglandins, 12, p. 915
  • Cho, Allen, Chemical stability of prostacyclin (PGI2) in aqueous solutions (1978) Prostaglandins, 15, p. 943
  • Sterin-Borda, Gimeno, Gimeno, Frequency force relationship on isolated rat and guinea pig atria (1974) Effects of cholinergic and adrenergic receptor antagonists, 145, p. 1151. , Proc. Soc.Exp.Biol.Med
  • Bunting, Gryglewski, Moncada, Vane, Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and colliac arteries and inhibits platelet aggregation (1976) Prostaglandins, 12, p. 897
  • Dusting, Moncada, Vane, Recirculation of prostacyclin (PGI2) in the dog (1978) Br.J.Pharmac., 64, p. 315
  • Hamber, Israelsson, Metabolism of prostaglandin E2 in guinea-pig liver (1970) I. Identification of seven metabolites, 245, p. 5107. , J.Biol.Chem
  • Leslie, Levine, Evidence for the presence of a prostaglandin E2 9-ketoreductase in rat organs (1973) Biochemical and Biophysical Research Communications, 53, p. 717
  • Hoult, Moore, Enzyme in rabbit kidnet converts prostaglandin F2 ∝ directly to prostaglandin E2 in vitro (1978) Br.J.Pharmac., 62, p. 415P
  • Pace-Asciak, Prostaglandin 9-hydroxydehydrogenase activity in the adult rat kidney (1975) Identification, assay, pathway and some enzyme properties, 250, p. 2789. , J.biol.Chem
  • Wong, Malik, Sun, Lee, McGiff, Hepatic metabolism of prostacyclin (PGI2) in the rabbit: formation of a potent inhibitor of platelet aggregation (1979) Proc. 4th Int.Conference on Prostaglandins, p. 127. , Washington
  • Lee, McGiff, Householder, Sun, Wong, Inhibition of platelet aggregation by 6-keto-prostaglandin E1 (6-KPGE1), a metabolite of 6-keto-prostaglandin F1 ∝ (6-KPGF1 ∝) (1979) Fed.Proc.Am.Soc.Exp.Biol., 38, p. 419
  • Quilley, Wong, McGiff, Hypotensive and renovascular actions of 6-keto-prostaglandin E1 a metabolite of prostacyclin (1979) Eur.J.Pharmacol., 57, p. 273
  • Gryglewski, Advances in Endoperoxides, Prostacyclin and Tromboxane Research (1979) 6th Course of the International School of Pharmacology, , Erice, Italy, In press
  • Szczeklik, Gryglewski, Nizankowski, Musial, Pieton, Mruk, Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men (1978) Pharm.Res.Comm., 10, p. 545

Citas:

---------- APA ----------
Gimeno, M.F., Sterin-Borda, L., Borda, E.S., Lazzari, M.A. & Gimeno, A.L. (1980) . Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries. Prostaglandins, 19(6), 907-916.
http://dx.doi.org/10.1016/0090-6980(80)90125-2
---------- CHICAGO ----------
Gimeno, M.F., Sterin-Borda, L., Borda, E.S., Lazzari, M.A., Gimeno, A.L. "Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries" . Prostaglandins 19, no. 6 (1980) : 907-916.
http://dx.doi.org/10.1016/0090-6980(80)90125-2
---------- MLA ----------
Gimeno, M.F., Sterin-Borda, L., Borda, E.S., Lazzari, M.A., Gimeno, A.L. "Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries" . Prostaglandins, vol. 19, no. 6, 1980, pp. 907-916.
http://dx.doi.org/10.1016/0090-6980(80)90125-2
---------- VANCOUVER ----------
Gimeno, M.F., Sterin-Borda, L., Borda, E.S., Lazzari, M.A., Gimeno, A.L. Human plasma transforms prostacyclin (PGI2) into a platelet antiaggregatory substance which contracts isolated bovine coronary arteries. Prostaglandins. 1980;19(6):907-916.
http://dx.doi.org/10.1016/0090-6980(80)90125-2