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Abstract:

The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time progresses, dissapearing almost completely following more than two hours. PGI2 produced a biphasic influence on quiescent preparations. After the threshold is attained lower concentrations caused depression of tone whereas higher ones enhanced the basal tone and induced phasic contractile cycles. Phentolamine reduced markedly the stimulating influence of PGI2 but had no action on the inhibitory effects, whereas propranolol failed to alter either the excitatory or the depressive action. The results suggest a participation of alpha-adrenoceptive-mediated mechanisms in the stimulatory effects of PGI2. On the other hand, PGI2 may be of importance in the regulation of venous flow and the spontaneous or PGI2-induced contractions could play a role in the counter current mechanism between veins and arteries in the ovarian pedicle. © 1980.

Registro:

Documento: Artículo
Título:Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
Autor:Borda, E.S.; Agostini, M.C.; Sterin-Speziale, N.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. V. de Obligado 2490., 1428 Buenos Aires, Argentina
Palabras clave:phentolamine; propranolol; prostacyclin; estrus; human; human cell; in vitro study; muscle contractility; normal human; ovarian vein; peripheral vascular system; venoconstriction; Adult; Epoprostenol; Female; Humans; Muscle Contraction; Ovary; Phentolamine; Propranolol; Prostaglandins; Veins
Año:1979
Volumen:18
Número:6
Página de inicio:829
Página de fin:835
DOI: http://dx.doi.org/10.1016/0090-6980(79)90120-5
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:phentolamine, 50-60-2, 73-05-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; prostacyclin, 35121-78-9, 61849-14-7; Epoprostenol, 35121-78-9; Phentolamine, 50-60-2; Propranolol, 525-66-6; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v18_n6_p829_Borda

Referencias:

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Citas:

---------- APA ----------
Borda, E.S., Agostini, M.C., Sterin-Speziale, N., Gimeno, M.F. & Gimeno, A.L. (1979) . Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2). Prostaglandins, 18(6), 829-835.
http://dx.doi.org/10.1016/0090-6980(79)90120-5
---------- CHICAGO ----------
Borda, E.S., Agostini, M.C., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L. "Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)" . Prostaglandins 18, no. 6 (1979) : 829-835.
http://dx.doi.org/10.1016/0090-6980(79)90120-5
---------- MLA ----------
Borda, E.S., Agostini, M.C., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L. "Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)" . Prostaglandins, vol. 18, no. 6, 1979, pp. 829-835.
http://dx.doi.org/10.1016/0090-6980(79)90120-5
---------- VANCOUVER ----------
Borda, E.S., Agostini, M.C., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L. Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2). Prostaglandins. 1979;18(6):829-835.
http://dx.doi.org/10.1016/0090-6980(79)90120-5