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Abstract:

Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (abolished by indomethacin) was observed up to 360 min. Uteri from proestrus and spayed animals exhibited a continuous depression without recovery during the whole experimental period. At 60 min, uterine horns from estrus animals (which showed a marked contractile decrement) released to the suspending medium significantly less prostaglandin E-like material than at 360 min, i.e. when contractions had almost completely recovered. No modification in the amount of prostaglandin F-like material was detected accompanying these spontaneous contractile variations. In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min. These findings suggest a possible control of rat uterine contractions by PGE, rather than by PGF. © 1979.

Registro:

Documento: Artículo
Título:Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
Autor:Gimeno, M.F.; Sterin-Speziale, N.; Landa, A.; Bonacossa, A.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET. Obligado 2490., 1428 Buenos Aires, Argentina
Palabras clave:indometacin; prostaglandin e; prostaglandin e2; prostaglandin f2 alpha; animal experiment; estrus; female genital system; in vitro study; metestrus; rat; uterus contraction; Animals; Estrus; Female; Indomethacin; Ovary; Pregnancy; Prostaglandins E; Prostaglandins F; Rats; Secretory Rate; Time Factors; Uterine Contraction
Año:1979
Volumen:17
Número:5
Página de inicio:673
Página de fin:683
DOI: http://dx.doi.org/10.1016/S0090-6980(79)80040-4
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:indometacin, 53-86-1, 74252-25-8, 7681-54-1; prostaglandin E, 11042-70-9; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Indomethacin, 53-86-1; Prostaglandins E; Prostaglandins F
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v17_n5_p673_Gimeno

Referencias:

  • Gimeno, Bedners, Goldraij, Gimeno, Studies on the contractile activity of myometrium isolated from ovariectomized rats (1970) Acta physiol.latinoam., 20, pp. 275-277
  • Lima, Gimeno, Goldraij, Bedners, Gimeno, Prostaglandin F2 alpha and motility of the myometrium isolated from ovariectomized rats. Effects of 17 beta-estradiol (1971) Life Sci, 10, pp. 999-1008. , (Part.I)
  • Gimeno, Gimeno, Goldraij, Sterin-Speziale, Pituitary and adrenal influences upon spontaneous contractions of uterine horns isolated from ovariectomized or natural estrus rats (1976) Reproducción, 3, pp. 235-246
  • Ham, Cirillo, Zanetti, Kuehl, Estrogen-direct synthesis of specific prostaglandins in uterus (1975) Proc.Nat.Acad.Sci.U.S.A., 72, pp. 1420-1424
  • Sharma, Garg, Measurement of prostaglandins E and F in uterine tissue and uterine fluid of ovariectomized rats treated with various doses of oestradiol 17 (1977) J.Reprod.Fert., 51, pp. 119-121
  • Vane, Williams, The contribution of prostaglandin production to contractions of the isolated uterus of the rat (1973) Br.J.Pharmac., 48, pp. 629-633
  • Williams, Vane, Inhibition of uterine motility: the possible role of the prostaglandins and aspirin-like drugs (1975) Pharmac.Ther. B, 1, pp. 89-113
  • Ferreira, Herman, Vane, Prostaglandin generation maintains the smooth muscle tone of the rabbit isolated jejunum (1972) Br.J.Pharmac., 44, pp. 328-329
  • Eckenfels, Vane, Prostaglandins, oxygen tension and smooth muscle tone (1972) Br.J.Pharmac., 45, pp. 451-462
  • Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacologic influences on human ovarian contractions (1976) Obstet.Gynec. (N.Y.), 47, p. 218
  • Vane, The use of isolated organs for detection active substances in the circulating blood (1964) Br.J.Pharmac.Chemother., 23, p. 360
  • Gilmore, Vane, Willie, Prostaglandins released by the spleen (1968) Nature (Lond.), 218, p. 1135
  • Walker, Poyser, Production of prostaglandins by the early pregnant guinea pig uterus “in vitro” (1974) Journal of Endocrinology, 61, pp. 265-271
  • Boling, Blandeau, The role of estrogen in egg transport through the ampullae of oviducts of castrate rabbit (1971) Fert.Steril., 22, pp. 544-551
  • Coutinho, de Mattos, Effects of estrogen on the Motility of the Non-atrophic Estrogen Deficient Rabbits Uterus (1968) Endocrinology, 83, pp. 422-432
  • Conrad, Bioelectrical and contractile behavior of rabbit mesotubarium superius: estrogen withdrawal (1977) Am.J.Physiol., 233, pp. C180-C187
  • Flower, Blackwell, The importance of phospholipase A2 in prostaglandin biosynthesis (1976) Biochem.Pharmac., 25, pp. 285-291

Citas:

---------- APA ----------
Gimeno, M.F., Sterin-Speziale, N., Landa, A., Bonacossa, A. & Gimeno, A.L. (1979) . Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?. Prostaglandins, 17(5), 673-683.
http://dx.doi.org/10.1016/S0090-6980(79)80040-4
---------- CHICAGO ----------
Gimeno, M.F., Sterin-Speziale, N., Landa, A., Bonacossa, A., Gimeno, A.L. "Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?" . Prostaglandins 17, no. 5 (1979) : 673-683.
http://dx.doi.org/10.1016/S0090-6980(79)80040-4
---------- MLA ----------
Gimeno, M.F., Sterin-Speziale, N., Landa, A., Bonacossa, A., Gimeno, A.L. "Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?" . Prostaglandins, vol. 17, no. 5, 1979, pp. 673-683.
http://dx.doi.org/10.1016/S0090-6980(79)80040-4
---------- VANCOUVER ----------
Gimeno, M.F., Sterin-Speziale, N., Landa, A., Bonacossa, A., Gimeno, A.L. Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?. Prostaglandins. 1979;17(5):673-683.
http://dx.doi.org/10.1016/S0090-6980(79)80040-4