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Abstract:

Endocrine-disrupting chemicals can influence the hypothalamus-pituitary- gonad axis and possibly affect reproduction in vertebrates. We analyzed the effect of 30-day endosulfan (ES) exposure in sexually undifferentiated larvae of the cichlid fish Cichlasoma dimerus. The number, area, mean cytoplasmic and nuclear diameter, and mean cytoplasmic optical density of gonadotropin-releasing hormone (GnRH) I, II, and III immunoreactive (ir-) neurons and β follicle-stimulating hormone (βFSH) ir-cells were measured. Animals exposed to the highest ES concentration (0.1 μg/l) showed a decrease in GnRH I nucleus/cytoplasm area ratio upon exposure. Nuclear area and mean nuclear diameter of βFSH ir-cells was higher in ES treated fish. βFSH nucleus/cytoplasm area ratio was high in exposed animals, and animals exposed to 0.1 μg/l ES showed smaller mean cytoplasmic optical density. These findings suggest that ES affects GnRH I and βFSH protein synthesis/release. However, these responses seem to be insufficient to affect gonadal differentiation at this stage of development. © 2010 Springer Science+Business Media, LLC.

Registro:

Documento: Artículo
Título:Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae
Autor:Piazza, Y.G.; Pandolfi, M.; Lo Nostro, F.L.
Filiación:Department of Biodiversity and Experimental Biology, Faculty of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires C1428EHA, Argentina
National Council of Scientific and Technical Research (CONICET), Buenos Aires C1033AAJ, Argentina
Palabras clave:endosulfan; follitropin beta subunit; gonadorelin; cell organelle; concentration (composition); developmental biology; diameter; endocrine disruptor; endosulfan; fish; functional morphology; hormone; larva; organochlorine; physiological response; pollution exposure; population structure; reproduction; article; cell population; Cichlasoma dimerus; cichlid; controlled study; cytoplasm; gonad development; larva; nonhuman; nucleus accumbens; optical density; priority journal; protein secretion; protein synthesis; Animals; Cichlids; Endosulfan; Environmental Exposure; Follicle Stimulating Hormone; Gonadotrophs; Gonadotropin-Releasing Hormone; Gonads; Hydrocarbons, Chlorinated; Insecticides; Larva; Neurons; Animalia; Cichlasoma; Cichlidae; Vertebrata
Año:2011
Volumen:61
Número:2
Página de inicio:300
Página de fin:310
DOI: http://dx.doi.org/10.1007/s00244-010-9621-3
Título revista:Archives of Environmental Contamination and Toxicology
Título revista abreviado:Arch. Environ. Contam. Toxicol.
ISSN:00904341
CODEN:AECTC
CAS:endosulfan, 115-29-7; gonadorelin, 33515-09-2, 9034-40-6; Endosulfan, 115-29-7; Follicle Stimulating Hormone, 9002-68-0; Gonadotropin-Releasing Hormone, 33515-09-2; Hydrocarbons, Chlorinated; Insecticides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00904341_v61_n2_p300_Piazza

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Citas:

---------- APA ----------
Piazza, Y.G., Pandolfi, M. & Lo Nostro, F.L. (2011) . Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae. Archives of Environmental Contamination and Toxicology, 61(2), 300-310.
http://dx.doi.org/10.1007/s00244-010-9621-3
---------- CHICAGO ----------
Piazza, Y.G., Pandolfi, M., Lo Nostro, F.L. "Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae" . Archives of Environmental Contamination and Toxicology 61, no. 2 (2011) : 300-310.
http://dx.doi.org/10.1007/s00244-010-9621-3
---------- MLA ----------
Piazza, Y.G., Pandolfi, M., Lo Nostro, F.L. "Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae" . Archives of Environmental Contamination and Toxicology, vol. 61, no. 2, 2011, pp. 300-310.
http://dx.doi.org/10.1007/s00244-010-9621-3
---------- VANCOUVER ----------
Piazza, Y.G., Pandolfi, M., Lo Nostro, F.L. Effect of the organochlorine pesticide endosulfan on GnRH and gonadotrope cell populations in fish larvae. Arch. Environ. Contam. Toxicol. 2011;61(2):300-310.
http://dx.doi.org/10.1007/s00244-010-9621-3