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Abstract:

It is demonstrated that murine chagasic IgG and the corresponding F(ab′)2 fragments interfere with β adrenergic and muscarinic cholinergic specific ligand occupancy on T cell-enriched population. From the interaction between chagasic IgG or F(ab′)2 with Lyt-1+ cells, an increase in cAMP levels occurs as a consequence of β adrenergic receptor activation. On the contrary, chagasic IgG or F(ab′)2 interactions with Lyt-2+ cells induce an activation of muscarinic cholinergic receptor, leading to an increment in cGMP. Muscarinic cholinergic and β adrenergic stimulation trigger the release of PGE2 and TXB2, respectively. Lyt-2+ cells treated with chagasic IgG or F(ab′)2 are able to decrease the contractility of mouse atria. The same negative inotropic effect is elicited with Lyt-2+ cells from Trypanosoma cruzi-infected mice susceptible to developed myocarditis. The implications of these results in the pathogenesis of Chagas' myocarditis are discussed. © 1990.

Registro:

Documento: Artículo
Título:Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease
Autor:Gorelik, G.; Genaro, A.M.; Sterin-Borda, L.; Cappa, S.G.; Borda, E.S.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales, Serrano 665, 1414 Buenos Aires, Argentina
Departamento de Microbiología, la Facultad de Medicina, la Universidad de Buenos Aires, Serrano 665, 1414 Buenos Aires, Argentina
Palabras clave:beta adrenergic receptor; cholinergic receptor; cyclic amp; cyclic gmp; immunoglobulin g; prostaglandin e2; animal experiment; article; chagas disease; mouse; myocarditis; nonhuman; priority journal; protozoon; trypanosoma cruzi; Animal; Atrial Function; Chagas Disease; Cyclic AMP; Cyclic GMP; Dinoprostone; Immunoglobulin G; Immunoglobulins, Fab; Lymphocytes; Mice; Mice, Inbred BALB C; Myocardial Contraction; Protein Binding; Receptors, Adrenergic, beta; Receptors, Cholinergic; Support, Non-U.S. Gov't; T-Lymphocytes; Thromboxane B2
Año:1990
Volumen:55
Número:2
Página de inicio:221
Página de fin:236
DOI: http://dx.doi.org/10.1016/0090-1229(90)90098-B
Título revista:Clinical Immunology and Immunopathology
Título revista abreviado:Clin. Immunol. Immunopathol.
ISSN:00901229
CODEN:CLIIA
CAS:Cyclic AMP, 60-92-4; Cyclic GMP, 7665-99-8; Dinoprostone, 363-24-6; Immunoglobulin G; Immunoglobulins, Fab; Receptors, Adrenergic, beta; Receptors, Cholinergic; Thromboxane B2, 54397-85-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00901229_v55_n2_p221_Gorelik

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Citas:

---------- APA ----------
Gorelik, G., Genaro, A.M., Sterin-Borda, L., Cappa, S.G. & Borda, E.S. (1990) . Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease. Clinical Immunology and Immunopathology, 55(2), 221-236.
http://dx.doi.org/10.1016/0090-1229(90)90098-B
---------- CHICAGO ----------
Gorelik, G., Genaro, A.M., Sterin-Borda, L., Cappa, S.G., Borda, E.S. "Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease" . Clinical Immunology and Immunopathology 55, no. 2 (1990) : 221-236.
http://dx.doi.org/10.1016/0090-1229(90)90098-B
---------- MLA ----------
Gorelik, G., Genaro, A.M., Sterin-Borda, L., Cappa, S.G., Borda, E.S. "Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease" . Clinical Immunology and Immunopathology, vol. 55, no. 2, 1990, pp. 221-236.
http://dx.doi.org/10.1016/0090-1229(90)90098-B
---------- VANCOUVER ----------
Gorelik, G., Genaro, A.M., Sterin-Borda, L., Cappa, S.G., Borda, E.S. Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease. Clin. Immunol. Immunopathol. 1990;55(2):221-236.
http://dx.doi.org/10.1016/0090-1229(90)90098-B