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Nudler, S.; Piriz, J.; Urbano, F.J.; Rosato-Siri, M.D.; Piedras Renteria, E.S.; Uchitel, O.D. "Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction" (2003) Annals of the New York Academy of Sciences. 998:11-17
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Abstract:

Different types of voltage-activated Ca2+ channels have been established based on their molecular structure and pharmacological and biophysical properties. One of them, the P/Q-type, is the main channel involved in nerve-evoked neurotransmitter release at neuromuscular junctions and the immunological target in Eaton-Lambert Syndrome. At adult neuromuscular junctions, L- and N-type Ca2+ channels become involved in transmitter release only under certain experimental or pathological conditions. In contrast, at neonatal rat neuromuscular junctions, nerve-evoked synaptic transmission depends jointly on both N- and P/Q-type channels. Synaptic transmission at neuromuscular junctions of the ataxic P/Q-type Ca2+ channel knockout mice is also dependent on two different types of channels, N- and R-type. At both neonatal and P/Q knockout junctions, the K +-evoked increase in miniature endplate potential frequency was not affected by N-type channel blockers, but strongly reduced by both P/Q- and R-type channel blockers. These differences could be accounted for by a differential location of the channels at the release site, being either P/Q- or R-type Ca2+ channels located closer to the release site than N-type Ca2+ channels. Thus, Ca2+ channels may be recruited to mediate neurotransmitter release where P/Q-type channels seem to be the most suited type of Ca2+ channel to mediate exocytosis at neuromuscular junctions.

Registro:

Documento: Artículo
Título:Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction
Autor:Nudler, S.; Piriz, J.; Urbano, F.J.; Rosato-Siri, M.D.; Piedras Renteria, E.S.; Uchitel, O.D.
Filiación:Lab. de Fisiol. y Biol. Molecular, Depto. Fisiol., Biol. Molec. y Cel., IFIBYNE-CONICET, Buenos Aires, Argentina
Dept. of Molec./Cellular Physiology, Stanford University, Stanford, CA, United States
Dept. of Physiology and Neuroscience, NYU School of Medicine, 550 First Avenue, New York, NY 10016, United States
Biophysics Sector, S.I.S.S.A./I.S.A.S., Via Beirut 2-4, 34014 Trieste, Italy
Department of Physiology, Loyola University Chicago, Maywood, IL 60153, United States
Depto. Fisiol., Biol. Molec. y Cel., Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II piso 2, Buenos Aires 1428, Argentina
Palabras clave:Calcium channels; Calcium dependence; Miniature endplate potentials; Neuromuscular junction; Transmitter release; calcium channel; calcium channel blocking agent; calcium channel L type; calcium channel N type; calcium channel P type; calcium channel Q type; calcium channel R type; immunoglobulin; neurotransmitter; nitrendipine; okadaic acid; omega agatoxin; omega agatoxin gvia; omega agatoxin IVA; snx 482; unclassified drug; agents interacting with transmitter, hormone or drug receptors; calcium channel N type; potassium; ataxia; chemical structure; conference paper; drug effect; dystonia; Eaton Lambert syndrome; electric potential; electrophysiology; endplate potential; exocytosis; experiment; genetic analysis; genetic code; human; immune system; knockout mouse; nerve ending; nerve potential; neuromuscular synapse; neurotransmitter release; nonhuman; pathophysiology; structure analysis; synaptic transmission; adult; aging; animal; classification; fetus; genetics; metabolism; mouse; neuromuscular junction disorder; newborn; physiology; rat; review; secretion; synaptic membrane; Ataxia; Adult; Aging; Animals; Animals, Newborn; Calcium Channels, L-Type; Calcium Channels, N-Type; Fetus; Humans; Mice; Neuromuscular Junction; Neuromuscular Junction Diseases; Neurotransmitter Agents; Potassium; Rats; Synaptic Membranes; Synaptic Transmission
Año:2003
Volumen:998
Página de inicio:11
Página de fin:17
DOI: http://dx.doi.org/10.1196/annals.1254.003
Título revista:Annals of the New York Academy of Sciences
Título revista abreviado:Ann. New York Acad. Sci.
ISSN:00778923
CODEN:ANYAA
CAS:immunoglobulin, 9007-83-4; nitrendipine, 39562-70-4; okadaic acid, 78111-17-8; potassium, 7440-09-7; Calcium Channels, L-Type; Calcium Channels, N-Type; Neurotransmitter Agents; Potassium, 7440-09-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v998_n_p11_Nudler

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Citas:

---------- APA ----------
Nudler, S., Piriz, J., Urbano, F.J., Rosato-Siri, M.D., Piedras Renteria, E.S. & Uchitel, O.D. (2003) . Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction. Annals of the New York Academy of Sciences, 998, 11-17.
http://dx.doi.org/10.1196/annals.1254.003
---------- CHICAGO ----------
Nudler, S., Piriz, J., Urbano, F.J., Rosato-Siri, M.D., Piedras Renteria, E.S., Uchitel, O.D. "Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction" . Annals of the New York Academy of Sciences 998 (2003) : 11-17.
http://dx.doi.org/10.1196/annals.1254.003
---------- MLA ----------
Nudler, S., Piriz, J., Urbano, F.J., Rosato-Siri, M.D., Piedras Renteria, E.S., Uchitel, O.D. "Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction" . Annals of the New York Academy of Sciences, vol. 998, 2003, pp. 11-17.
http://dx.doi.org/10.1196/annals.1254.003
---------- VANCOUVER ----------
Nudler, S., Piriz, J., Urbano, F.J., Rosato-Siri, M.D., Piedras Renteria, E.S., Uchitel, O.D. Ca2+ channels and synaptic transmission at the adult, neonatal, and P/Q-type deficient neuromuscular junction. Ann. New York Acad. Sci. 2003;998:11-17.
http://dx.doi.org/10.1196/annals.1254.003