Artículo

Arzt, E.; Kovalovsky, D.; Müller Igaz, L.; Costas, M.; Plazas, P.; Refojo, D.; Páez-Pereda, M.; Reul, J.M.H.M.; Stalla, G.; Holsboer, F. "Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action" (2000) Annals of the New York Academy of Sciences. 917:672-677
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Abstract:

The main communicators between the neuroendocrine and immune systems are cytokines and hormones. We studied the molecular interaction between immune activators (cytokines and T-cell receptors [TCRs]) and the glucocorticoid receptor (GR) in cells in which glucocorticoids play a key regulatory function: (1) cellular targets of TNF-induced cytotoxicity; (2) the pituitary gland; and (3) thymic cells. Cytokines (TNF-alpha and IL-1) increase glucocorticoid-induced transcriptional activity of the GR via the DNA-glucocorticoid response elements (GREs) in cells transfected with a glucocorticoid-inducible reporter plasmid. As a functional physiological correlate, priming of fibroblastic cells with a low dose of TNF significantly increases the sensitivity to glucocorticoid inhibition of TNF-induced apoptosis (without involving NF-κB). Priming of AtT-20 mouse corticotrophs and Cushing pituitary cells with IL-1 increases the sensitivity to glucocorticoid inhibition of CRH-induced ACTH/POMC expression. In thymocytes, activation of the T-cell receptor counteracts the glucocorticoid-induced thymic apoptosis by downregulating the glucocorticoid action on GRE-driven apoptotic genes. Thus, cytokines and immune mediators prevent their own deleterious effects not only by stimulating glucocorticoid production, but also by modifying the sensitivity of the target cells for the glucocorticoid counter-regulatory action. The functional cross-talk at the molecular level between immune signals and glucocorticoids is essential to determine the biological response to both mediators and constitutes the ultimate level of interaction between the immune and neuroendocrine mediators.

Registro:

Documento: Artículo
Título:Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action
Autor:Arzt, E.; Kovalovsky, D.; Müller Igaz, L.; Costas, M.; Plazas, P.; Refojo, D.; Páez-Pereda, M.; Reul, J.M.H.M.; Stalla, G.; Holsboer, F.
Filiación:Laboratorio de Fisiología y Biología Molecular, University of Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Argentine National Research Council (CONICET), 80804 Munich, Germany
Max-Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany
Lab. Fisiologia y Biologia Molecular, Dept. Ciencias Biologicas, Pabellon II, Ciudad Universitaria, (1428), Buenos Aires, Argentina
Palabras clave:cytokine; glucocorticoid; glucocorticoid receptor; immunoglobulin enhancer binding protein; interleukin 1; T lymphocyte receptor; tumor necrosis factor; tumor necrosis factor alpha; apoptosis; conference paper; cytotoxicity; genetic transcription; genetic transfection; human; hypophysis; immune system; molecular interaction; neuroendocrine system; nonhuman; protein expression; receptor upregulation; signal transduction
Año:2000
Volumen:917
Página de inicio:672
Página de fin:677
Título revista:Annals of the New York Academy of Sciences
Título revista abreviado:Ann. New York Acad. Sci.
ISSN:00778923
CODEN:ANYAA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v917_n_p672_Arzt

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Citas:

---------- APA ----------
Arzt, E., Kovalovsky, D., Müller Igaz, L., Costas, M., Plazas, P., Refojo, D., Páez-Pereda, M.,..., Holsboer, F. (2000) . Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action. Annals of the New York Academy of Sciences, 917, 672-677.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v917_n_p672_Arzt [ ]
---------- CHICAGO ----------
Arzt, E., Kovalovsky, D., Müller Igaz, L., Costas, M., Plazas, P., Refojo, D., et al. "Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action" . Annals of the New York Academy of Sciences 917 (2000) : 672-677.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v917_n_p672_Arzt [ ]
---------- MLA ----------
Arzt, E., Kovalovsky, D., Müller Igaz, L., Costas, M., Plazas, P., Refojo, D., et al. "Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action" . Annals of the New York Academy of Sciences, vol. 917, 2000, pp. 672-677.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v917_n_p672_Arzt [ ]
---------- VANCOUVER ----------
Arzt, E., Kovalovsky, D., Müller Igaz, L., Costas, M., Plazas, P., Refojo, D., et al. Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action. Ann. New York Acad. Sci. 2000;917:672-677.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v917_n_p672_Arzt [ ]